Adenoviral mediated suicide gene transfer in the treatment of pancreatic cancer

Chinese Medical Journal

Volumn 115, Issue 8, 2002, Pages 1205-1208

  Pan, Xue ^a   Li, Zhaoshen ^a   Xu, Guoming ^a   Cui, Long ^a   Zhang, Suzhen ^a   Gong, Yanfang ^a   Tu, Zhenxing ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Adenovirus vector; Cytosine deaminase; Gene therapy; Pancreatic cancer

Indexed keywords

ADENOVIRUS VECTOR; CESIUM CHLORIDE; CYTOSINE DEAMINASE; ENDONUCLEASE; FLUCYTOSINE; GREEN FLUORESCENT PROTEIN; PRODRUG; DEAMINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CELL COUNT; CELL VIABILITY; CENTRIFUGATION; CLINICAL PROTOCOL; CONTROLLED STUDY; CYTOTOXICITY; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; NUDE MOUSE; PANCREAS CANCER; SUICIDE GENE THERAPY; TUMOR XENOGRAFT; VIRAL GENE DELIVERY SYSTEM; VIRUS INFECTION; VIRUS INFECTIVITY; ADENOVIRUS; ANIMAL; BAGG ALBINO MOUSE; GENE TRANSFER; GENE VECTOR; GENETICS; PANCREAS TUMOR;

ADENOVIRIDAE; ANIMAL; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMAN; MICE; MICE, INBRED BALB C; NUCLEOSIDE DEAMINASES; PANCREATIC NEOPLASMS; SUPPORT, NON-U.S. GOV'T; ANIMALS; CYTOSINE DEAMINASE; HUMANS;

EID: 0036674989     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Directed enzyme prodrug gene therapy for pancreatic cancer in vivo
2. Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor
3. In vivo adenovirus mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-Fluorocytosine
4. Cytotoxic effect of the cytosine deaminase gene delivered by the adenovirus vector in murine gastric cancer
5. Methods for construction of adenovirus vectors
6. In vivo adenoviral-mediated gene transfer in the treatment of pancreatic cancer
7. The "bystander effect": Association of U-87 cell death with ganciclovir-mediated apoptosis of nearbycells and lack of effect in athymic mice
8. An adenovirus mutant that replicates selectively in p53 deficient human tumor cells