Saturated patterned excitation microscopy - A concept for optical resolution improvement

Journal of the Optical Society of America A: Optics and Image Science, and Vision

Volumn 19, Issue 8, 2002, Pages 1599-1609

  Heintzmann, Rainer ^a   Jovin, Thomas M ^a   Cremer, Christoph ^b  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENCE; OPTICAL MICROSCOPY; OPTICAL RESOLVING POWER; OPTICAL TRANSFER FUNCTION; STIMULATED EMISSION;

POINT-SPREAD FUNCTIONS;

OPTICAL DEVICES;

ARTICLE; COMPUTER INTERFACE; COMPUTER SIMULATION; MICROSCOPY; NONLINEAR SYSTEM; OPTICS; THEORETICAL MODEL;

COMPUTER SIMULATION; MICROSCOPY; MODELS, THEORETICAL; NONLINEAR DYNAMICS; OPTICS; USER-COMPUTER INTERFACE;

EID: 0036674522     PISSN: 10847529     EISSN: None     Source Type: Journal    
DOI: 10.1364/JOSAA.19.001599     Document Type: Article

References (42)

1. R. Heintzmann and C. Cremer, "Lateral modulated excitation microscopy: improvement of resolution by using a diffraction grating," in Optical Biopsies and Microscopic Techniques III, I. J. Bigio, H. Schneckenburger, J. Slavik, K. Svanberg, and P. M. Viallet, eds., Proc. SPIE 3568, 185-196 (1999).
2. M. G. L. Gustafsson, "Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy," J. Microsc. 198, 82-87 (2000).
3. T. Wilson, R. Juskaitis, and M. A. A. Neil, "A new approach to three dimensional imaging in microscopy," Cell Vision 4, 231 (1997).
4. M. A. A. Neil, R. Juskaitis, and T. Wilson, "Method of obtaining optical sectioning by using structured light in a conventional microscope, " Opt. Lett. 22, 1905-1907 (1997).
5. M. G. L. Gustafsson, "Doubling the lateral resolution of wide-field fluorescence microscopy using structured illumination," in Three-Dimensional and Multidimensional Microscopy: Image Acquisition Processing VII, J. Conchello, C. J. Cogswell, and T. Wilson, eds., Proc. SPIE 3919, 141-150 (2000).
6. J. T. Frohn, H. F. Knapp, and A. Stemmer, "True optical resolution beyond the Rayleigh limit achieved by standing wave illumination," Proc. Natl. Acad. Sci. USA 97, 7232-7236 (2000).
7. J. T. Frohn, H. F. Knapp, and A. Stemmer, "Three-dimensional resolution enhancement in fluorescence microscopy by harmonic excitation," Opt. Lett. 26, 828-830 (2001).
8. M. Nagorni and S. W. Hell, "Coherent use of opposing lenses for axial resolution increase in fluorescence microscopy. I. comparative study of concepts," J. Opt. Soc. Am. A 18, 36-48 (2001).
9. M. Minsky, "Microscopy apparatus," U.S. patent 3,013,467, December 19, 1961.
10. F. Lanni, B. Bailey, D. L. Farkas, and D. L. Taylor, "Excitation field synthesis as a means for obtaining enhanced axial resolution in fluorescence microscopes," Bioimaging 1, 187-196 (1993).
11. F. Lanni, D. L. Taylor, and B. Bailey, "Field synthesis and optical subsectioning for standing wave microscopy," U.S. patent 5,801,881, September 1, 1998.
12. B. Albrecht, A. V. Failla, R. Heintzmann, and C. Cremer, "Spatially modulated illumination microscopy: online visualization of intensity distribution and prediction of nanometer precision of axial distance measurements by computer simulations," J. Biomed. Opt. 6, 292-299 (2001).
13. S. W. Hell, S. Lindek, C. Cremer, and E. H. K. Stelzer, "Measurement of the 4pi-confocal point spread function proves 75 nm axial resolution," Appl. Phys. Lett. 64, 1335-1337 (1994).
14. S. W. Hell, M. Schrader, and H. T. M. van der Voort, "Farfield fluorescence microscopy with three-dimensional resolution in the 100 nm range," J. Microsc. 185, 1-5 (1997).
15. M. G. L. Gustafsson, D. A. Agard, and J. W. Sedat, "3D widefield microscopy with two objective lenses: experimental verification of improved axial resolution," in Three-Dimensional Microscopy: Image Acquisition and Processing III, C. J. Cogswell, G. S. Kino, and T. Wilson, eds., Proc. SPIE 2655, 62-66 (1996).
16. M. Gustafsson, J. Sedat, and D. Agard, "Method and apparatus for three-dimensional microscopy with enhanced depth resolution," U.S. patent 5,671,085, September 23, 1997.
17. 5M: 3D widefield light microscopy with better than 100 nm axial resolution," J. Microsc. 195, 10-16 (1999).
18. R. Juskaitis, T. Wilson, M. A. A. Neil, and M. Kozubek, "Efficient real-time confocal microscopy with white licht sources," Nature (London) 383, 804-806 (1996).
19. T. Wilson, R. Juskaitis, M. A. A. Neil, and M. Kozubeck, "An aperture correlation approach to confocal microscopy," in Three-Dimensional Microscopy: Image Acquisition and Processing IV, C. J. Cogswell, J. Conchello, and T. Wilson, eds., Proc. SPIE 2984, 21-23 (1997).
20. In the literature patterned excitation techniques have also been named structured illumination microscopy, harmonic excitation light microscopy (HELM) and laterally modulated excitation (LMEM).
21. P. J. Shaw, D. A. Agard, Y. Hirakoa, and J. W. Sedat, "Tilted view reconstruction in optical microscopy: three dimensional reconstruction of drosophila melanogaster embryo nuclei," Biophys. J. 55, 101-110 (1989).
22. R. Heintzmann, G. Kreth, and C. Cremer, "Reconstruction of axial tomographic high resolution data from confocal fluorescence microscopy - a method for improving 3D FISH images," Anal. Cell Pathol. 20, 7-15 (2000).
23. R. Heintzmann and C. Cremer, "Axial tomographic confocal fluorescence microscopy" J. Microsc. 206, 7-23 (2002).
24. K. Ichie, "Laser scanning optical system and laser scanning optical apparatus," U.S. patent 5,796,112, August 18, 1998.
25. P. Hänninen and S. Hell, "Luminescence-scanning microscopy process and a luminescence scanning microscope utilizing picosecond or greater pulse lasers," U.S. patent 5,777,732, July 7, 1998.
26. W. Denk, J. H. Strickler, and W. W. Webb, "Two-photon fluorescence scanning microscopy," Science 248, 73-76 (1990).
27. S. W. Hell and M. Kroug, "Ground-state depletion fluorescence microscopy, a concept for breaking the diffraction resolution limit," Appl. Phys. B 60, 495-497 (1995).
28. S. W. Hell, "Increasing the resolution of far-field fluorescence light microscopy by point-spread-function engineering," in Topics in Fluorescence Spectroscopy: Nonlinear and Two-Photon-Induced Fluorescence, J. Lakowicz, ed. (Plenum, New York, 1997), Vol. 5, pp. 361-426.
29. S. W. Hell and J. Wichmann, "Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy," Opt. Lett. 19, 780-782 (1994).
30. T. A. Klar, S. Jakops, M. Dyba, and S. W. Hell, "Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission," Proc. Natl. Acad. Sci. USA 97, 8206-8210 (2000).
31. A. Schönle, P. E. Hänninen, and S. W. Hell, "Nonlinear fluorescence through intermolecular energy transfer and resolution increase in fluorescence microscopy," Ann. Phys. (Leipzig) 8, 115-133 (1999).
32. A. Schönle and S. W. Hell, "Far-field fluorescence microscopy with repetitive excitation," Eur. Phys. J. D 6, 283-290 (1999).
33. D. R. Sandison, R. M. Williams, K. S. Wells, J. Strickler, and W. W. Webb, "Quantitative fluorescence confocal laser scanning microscopy (CLSM)," in Handbook of Biological Confocal Microscopy, 2nd ed., J. B. Pawley, ed. (Plenum, New York, 1995), pp. 47-50.
34. R. Y. Tsien and A. Waggoner, "Fluorophores for confocal microscopy," in Handbook of Biological Confocal Microscopy, 2nd ed., J. B. Pawley, ed. (Plenum, New York, 1995), pp. 267-268.
35. A. Egner and S. W. Hell, "Equivalence of the Huygens-Fresnel and Debye approach for the calculation of high aperture point-spread functions in the presence of refractive index mismatch," J. Microsc. 193, 244-249 (1999).
36. R. Y. Tsien and A. Waggoner, "Fluorophores for confocal microscopy," in Handbook of Biological Confocal Microscopy, 2nd ed., J. B. Pawley, ed. (Plenum, New York, 1995), pp. 269, 272.
37. Q. S. Hanley, P. J. Verveer, M. J. Gemkov, D. Arndt-Jovin, and T. M. Jovin, "An optical sectioning programmable array microscope implemented with a digital micromirror device," J. Microsc. 196, 317-331 (1999).
38. R. Heintzmann, Q. S. Hanley, D. Arndt-Jovin, and T. M. Jovin, "A dual path programmable array microscope (PAM): simultaneous acquisition of conjugate and non-conjugate images," J. Microsc. 204, 119-137 (2001).
39. P. A. Benedetti, V. Evangelista, D. Guidarini, and S. Vestri "Method for the acquisition of images by confocal," U.S. patent 6,016,367, January 18, 2000.
40. M. Sargent III, M. O. Scully and W. E., Jr., Lamb, Laser Physics (Addison-Wesley, London, 1982) (4th printing).
41. P. J. Sementilli, B. R. Hunt, and M. S. Nadar, "Analysis of the limit to superresolution in incoherent imaging," J. Opt. Soc. Am. A 10, 2265-2276 (1993).
42. D. Gabor, "Theory of communication," J. Inst. Electr. Eng. 63, 429-457 (1946).