Effects of ZMS on deposition of β-amyloid peptide and cholinergic function in rats with β-amyloid injection into right nucleus basalis magnocellularis

Chinese Pharmacological Bulletin

Volumn 18, Issue 4, 2002, Pages 390-393

  Chen, Qin ^a   Xia, Zong Qin ^a   Hu, Ya Er ^a  

^a ANHUI UNIVERSITY   (China)

Author keywords

ChAT; Dementia like rat model; Immunohistochemistry; Sapogenin from Zhimu (ZMS); amyloid peptide

Indexed keywords

AMYLOID BETA PROTEIN; CHOLINE ACETYLTRANSFERASE; EXCITATORY AMINO ACID; MUSCARINIC RECEPTOR; SAPOGENIN; SARSASAPOGENIN; TRITIUM;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DEMENTIA; ELECTROENCEPHALOGRAM; ENZYME ACTIVITY; GIANT CELL; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LEARNING; MEMORY; NONHUMAN; OLIVARY NUCLEUS; RAT; RECEPTOR DENSITY;

EID: 0036670874     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Differential effects of amyloid peptides β-(1-40) and β-(25-35) injections into the rat nucleus basalis
2. Continuous infusion of beta-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration
3. Beta-amyloid [Phe (SO3H)24]25-35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation
4. Co-injection of beta-amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons
5. Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: Implication of oxidative stress in beta amyloid induced neurotoxicity in vivo
6. Morphological, biochemical and behavioural changes induced by neurotoxic and inflammatory insults to the nucleus basalis
7. Rodent models of Alzheimer's disease: Rat A beta infusion approaches to amyloid deposits
8. Long-term changes in the aggregation state and toxic effects of beta-amyloid injected into the rat brain