Differentiating benign nevi from malignant melanoma using DNA microdensitometry and karyometry and maturation: A zonal comparison, correlation and multivariate analysis

Analytical and Quantitative Cytology and Histology

Volumn 24, Issue 4, 2002, Pages 234-243

  Li, Ling Xi L ^a   Crotty, Kerry A ^a   Palmer, Allan A ^a   Kril, Jillian J ^a   Stankovic, Roger ^a   Scolyer, Richard A ^a   McCarthy, Stanley W ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Karyometry; Malignant melanoma; Microdensitometry; Nevus, dysplastic; Spitz nevus

Indexed keywords

CELL NUCLEUS DNA; DNA;

ARTICLE; BENIGN TUMOR; CELL MATURATION; CHROMATIN CONDENSATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOMETRY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DNA CONTENT; DYSPLASIA; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; JUVENILE MELANOMA; KARYOMETRY; MELANOCYTIC NEVUS; MELANOMA; MICRODENSITOMETRY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; TUMOR CELL; VIDEORECORDING; ADOLESCENT; ADULT; AGED; CHILD; CHROMATIN; DENSITOMETRY; DIFFERENTIAL DIAGNOSIS; METHODOLOGY; MIDDLE AGED; NEVUS; PATHOLOGY; PLOIDY; SKIN TUMOR;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHROMATIN; DENSITOMETRY; DIAGNOSIS, DIFFERENTIAL; DNA, NEOPLASM; HUMAN; KARYOMETRY; MELANOMA; MIDDLE AGE; MULTIVARIATE ANALYSIS; NEVUS, EPITHELIOID AND SPINDLE CELL; PLOIDIES; SKIN NEOPLASMS; HUMANS; MIDDLE AGED;

EID: 0036667896     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. The adjuvant prognostic value of nuclear morphometry in stage I malignant melanoma of the skin
2. Cellular DNA content as a marker of neoplasia in man
3. Current status of the dysplastic melanocytic naevus
4. Cutaneous melanoma and atypical spitz tumors in childhood
5. The histopathology of cutaneous malignant melanoma
6. Melanocytic atypia in dysplastic nevi: Immunohistochemical and cytophotometrical analysis
7. Nuclear DNA analyses in archival material from primary malignant melanoma: A pilot study
8. Comparison of nuclear DNA content in primary and metastatic malignant melanoma
9. Algorithm for a DNA-cytophotometric diagnosis and grading of malignancy
10. Algorithm for DNA-cytophotometric diagnosis and grading of malignancy
11. Consensus report of the European Society for Analytical Cellular Pathology task force on standardization of diagnostic DNA image cytometry
12. Common acquired melanocytic nevi, dysplastic melanocytic nevi and malignant melanomas: An image analysis cytometric study
13. Differential pattern of DNA-aneuploidy in human malignancies
14. Use of DAPI cytofluorometric analysis of cellular DNA content to differentiate spitz nevus from malignant melanoma
15. Comparison of image analysis of imprints with flow cytometry for DNA analysis of solid tumors
16. Spitz naevus: Histological features and distinction from malignant melanoma
17. Atlas of tumor pathology: Melanocytic tumors of the skin
18. Discordance in the histopathologic diagnosis of melanoma and melanocytic nevi between expert pathologists
19. Benign melanocytic lesions: A morphometric analysis
20. Nuclear indices and survival in cutaneous melanoma
21. Questions to the editorial board and other authorities: What are your five most important histologic criteria for the diagnosis of malignant melanoma?
22. DNA ploidy and S-phase in primary malignant melanoma as prognostic factors for stage III disease
23. Prognostic significance of DNA aneuploidy in stage I cutaneous melanoma
24. A retrospective histological study of 669 cases of primary cutaneous malignant melanoma in clinical stage I: 2. The relation of cell type, pigmentation, atypia and mitotic count to histological type and prognosis
25. A comparative study of spitz nevus and nodular malignant melanoma using image analysis cytometry
26. Effect of melanin bleach on Feulgen-DNA microdensitometry in pigmented lesions
27. DNA-cytophotometry of benign compound and intradermal naevi, Spitz epithelioid naevi and malignant melanomas
28. Caryometry of benign compound acquired naevi, spitz epithelioid naevi and malignant melanomas
29. Histologic criteria for the diagnosis of superficial spreading malignant melanoma: Formulated on the basis of proven metastatic lesions
30. Common and uncommon melanocytic naevi and borderline melanomas
31. Nuclear DNA profiles in primary melanomas and their metastases
32. S100 protein, neurone specific enolase, and nuclear DNA content in spitz nevus
33. DNA determination in dysplastic nevi: A comparative study between cytometry and image analysis
34. Comparison of image analysis with flow cytometry for DNA content analysis in pigmented lesions of the skin
35. Analysis of melanocytic lesions by DNA image cytometry
36. How consistent are dermatopathologists in reading early malignant melanomas and lesions "precursor" to them?
37. Hematoxylin and Feulgen reagent in nuclear staining
38. Approach to diagnostic image analysis of melanocytic tumors
39. Nuclear parameters in the superficial and deep portion of melanocytic lesions: A morphometric investigation
40. Diagnostic impact of nuclear DNA content and proliferative activity in benign and malignant melanocytic lesions
41. DNA aneuploidy in congenital melanocytic nevi: Suggestive evidence for premalignant changes
42. Morphometric and ultrastructural analyses of melanocytes, nevi cells, and melanoma cells
43. Differentiation between maligant melanomas and benign melanocytic nevi by computerized DNA cytometry of imprint specimens
44. Evaluation of prognostic characteristic of stage I cutaneous malignant melanoma
45. The nuclei in cutaneous malignant melanoma, stage I, are smaller in survivors than in non-survivors
46. Multivariate DNA cytometry discriminates between Spitz naevi and melanomas because large polymorphic nuclei in Spitz naevi are not aneuploid
47. Malignant melanoma: Analysis by DNA flow cytometry
48. Influence of section thickness, mean nuclear diameter and nuclear crowding on DNA ploidy in histologic sections of melanocytic skin lesions
49. Discrimination between benign and malignant melanocytic skin lesions by multivariate analysis, quantitative S-100 immunohistochemistry, nuclear morphometry and DNA cytometry
50. Evaluation of DNA ploidy in dysplastic and spitz nevi by flow cytometry