Identification and characterization of (3″,4″-dihydroxy)-1,N2- benzetheno-2′-deoxyguanosine 3′-monophosphate, a novel DNA adduct formed by benzene metabolites

Chemical Research in Toxicology

Volumn 15, Issue 8, 2002, Pages 1088-1095

  Gaskell, Margaret ^a   Jukes, Rebekah ^b   Jones, Donald J L ^a   Martin, Elizabeth A ^a,b   Farmer, Peter B ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b MRC TOXICOLOGY UNIT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

(3'' HYDROXY) 1,N2 BENZETHENO 2' DEOXYGUANOSINE 3' PHOSPHATE; (3'',4'' DIHYDROXY) 1,N2 BENZETHENO 2' DEOXYGUANOSINE 3' PHOSPHATE; BENZENE DERIVATIVE; GUANOSINE DERIVATIVE; UNCLASSIFIED DRUG; (3'',4'' DIHYDROXY) 1,N(2) BENZETHENO 2' DEOXYGUANOSINE 3' MONOPHOSPHATE; (3'',4''-DIHYDROXY)-1,N(2)-BENZETHENO-2'-DEOXYGUANOSINE 3'-MONOPHOSPHATE; 2' DEOXYGUANOSINE 3' PHOSPHATE; 2'-DEOXYGUANOSINE 3'-PHOSPHATE; BENZENE; DEOXYGUANOSINE PHOSPHATE; DNA;

AQUEOUS SOLUTION; ARTICLE; CHROMATOGRAPHY; COVALENT BOND; DNA ADDUCT; DRUG DNA BINDING; PROTEIN ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SISTER CHROMATID EXCHANGE; ULTRAVIOLET SPECTROSCOPY; ANIMAL; CATTLE; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM;

ANIMAL; BENZENE; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANINE NUCLEOTIDES; DNA; DNA ADDUCTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; ANIMALS;

EID: 0036667461     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0255368     Document Type: Article

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