Risk assessment of high-energy chemicals by in vitro toxicity screening and quantitative structure-activity relationships

Toxicological Sciences

Volumn 68, Issue 2, 2002, Pages 498-507

  Trohalaki, Steven ^a,b   Zellmer, Robert J ^a   Pachter, Ruth ^b   Hussain, Saber M ^c   Frazier, John M ^b  

^a Technical Management Concepts Inc   (United States)

^b AIR FORCE RESEARCH LABORATORY   (United States)

^c ALION SCIENCE AND TECHNOLOGY   (United States)

Author keywords

High energy chemicals; Hydrazine; In vitro toxicity; QSAR; Risk assessment

Indexed keywords

1,2 DIETHYLHYDRAZINIUM NITRATE; 1,2,4 TRIAZOLE NITRATE; 1,4 DIHYDRAZINOTETRAZINE NITRATE; 2 HYDROXYETHYLHYDRAZINIUM NITRATE; 2,2 DIMETHYLTRIAZINIUM NITRATE; 4 AMINO 1,2,4 TRIAZOLE NITRATE; AMINO ACID DERIVATIVE; CHEMICAL COMPOUND; DIAMINOGUANDINE NITRATE; ETHANOLAMINE NITRATE; GLUTATHIONE; HISTAMINE DINITRATE; HYDRAZINE DERIVATIVE; HYDRAZINIUM NITRATE; LACTATE DEHYDROGENASE; METHOXYLAMINE NITRATE; METHYLHYDRAZINIUM NITRATE; NITRIC ACID DERIVATIVE; NITROAMINOGUANDINE NITRATE; PROPELLANT; QUATERNARY AMMONIUM DERIVATIVE; REACTIVE OXYGEN METABOLITE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANALYTICAL PARAMETERS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION COEFFICIENT; IN VITRO STUDY; LIVER CELL CULTURE; MALE; MITOCHONDRION; NONHUMAN; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; RISK ASSESSMENT; TOXICITY TESTING; AIRCRAFT; ANIMAL; CELL CULTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; LIVER CELL; METABOLISM; METHODOLOGY; PATHOLOGY;

AIRCRAFT; ANIMAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HEPATOCYTES; HYDRAZINES; LACTATE DEHYDROGENASE; MITOCHONDRIA; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; REACTIVE OXYGEN SPECIES; RISK ASSESSMENT; SUPPORT, U.S. GOV'T, NON-P.H.S.; TOXICITY TESTS; ANIMALS; L-LACTATE DEHYDROGENASE;

ANIMALIA;

EID: 0036667373     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/68.2.498     Document Type: Article

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