Gene therapy and the germ line

Molecular Therapy

Volumn 6, Issue 1, 2002, Pages 2-4

  Gura, Trisha ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; PLASMID DNA; RETROVIRUS VECTOR;

CHROMOSOME 19; DNA SEQUENCE; EDITORIAL; FERTILIZATION IN VITRO; FOOD AND DRUG ADMINISTRATION; GENE THERAPY; GERM LINE; HEMOPHILIA; HUMAN; NONHUMAN; OOCYTE; OVARY; RISK BENEFIT ANALYSIS; SPERM; TESTIS; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; UNIDENTIFIED RETROVIRUS;

EID: 0036665557     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0642     Document Type: Editorial

References (7)

1. Walters, L. (1986). The ethics of gene therapy. Nature 320: 225-227.
2. Friedmann, T., and Roblin, R. (1972). Gene therapy for human genetic disease? Science 175: 949-955.
3. Arruda, V. R., et al. (2001). Lack of germline transmission of vector sequences following systemic administration of recombinant AAV-2 vector in males. Mol. Ther. 4: 586-592.
4. Kay, M. A., et al. (2000). Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nat. Genet. 24: 257-261.
5. Favre, D., et al. (2001). Immediate and long-term safety of recombinant adeno-associated virus injection into the nonhuman primate muscle. Mol. Ther. 4: 559-566.
6. Gordon, J. W. (2001). Direct exposure of mouse ovaries and oocytes to high doses of an adenovirus gene therapy vector fails to lead to germ cell transduction. Mol. Ther. 3: 557-564.
7. Hall, S. J., Bar-Chama, N., Ta, S., and Gordon, J. W. (2000). Direct exposure of mouse spermatogenic cells to high doses of adenovirus gene therapy vector does not result in germ cell transduction. Hum. Gene Ther. 10: 1705-1712.