Transgenic calmodulin-dependent protein kinase II activation: Dose-dependent effects on synaptic plasticity, learning, and memory

Journal of Neuroscience

Volumn 22, Issue 13, 2002, Pages 5719-5726

  Bejar, Rafael ^a   Yasuda, Rie ^b,d   Krugers, Harmen ^c   Hood, Kristin ^a   Mayford, Mark ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

CaMKII; Genetic compensation; Long term potentiation; Memory; Mice; Tetracycline; Transgenic

Indexed keywords

DNA; MESSENGER RNA; PROTEIN KINASE (CALCIUM,CALMODULIN) II;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HIPPOCAMPUS; LEARNING; LONG TERM POTENTIATION; MEMORY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE;

EID: 0036663023     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-13-05719.2002     Document Type: Article

References (31)

1. Bach ME, Hawkins RD, Osman M, Kandel ER, Mayford M (1995) Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell 81:905-915.
2. Devan BD, Goad EH, Petri HL (1996) Dissociation of hippocampal and striatal contributions to spatial navigation in the water maze. Neurobiol Learn Mem 66:305-323.
3. Devan BD, McDonald RJ, White NM (1999) Effects of medial and lateral caudate-putamen lesions on place- and cue-guided behaviors in the water maze: Relation to thigmotaxis. Behav Brain Res 100:5-14.
4. Enslen H, Soderling TR (1994) Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes. J Biol Chem 269:20872-20877.
5. 2+/calmodulin-dependent protein kinase. IV. Role in transcriptional regulation. J Biol Chem 269:15520-15527.
6. 2+ calmodulin-dependent protein kinase II. J Biol Chem 268:7863-7867.
7. Giese KP, Fedorov NB, Filipkowski RK, Silva AJ (1998) Autophosphorylation at thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science 279:870-873.
8. Glazewski S, Bejar R, Mayford M, Fox K (2001) The effect of autonomous alpha-CaMKII expression on sensory responses and experience-dependent plasticity in mouse barrel cortex. Neuropharmacology 41:771-778.
9. Gossen M, Bujard H (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547-5551.
10. Hayashi Y, Shi SH, Esteban JA, Piccini A, Poncer JC, Malinow R (2000) Driving AMPA receptors into synapses by LTP and CaMKII: Requirement for GluR1 and PDZ domain interaction. Science 287:2262-2267.
11. Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP, Ross EM, Gilman AG, Worley PF (1998) Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. J Neurosci 18:7178-7188.
12. Inokuchi K, Kato A, Hiraia K, Hishinuma F, Inoue M, Ozawa F (1996) Increase in activin beta A mRNA in rat hippocampus during long-term potentiation. FEBS Lett 382:48-52.
13. Lai M, Sirimanne E, Williams CE, Gluckman PD (1996) Sequential patterns of inhibin subunit gene expression following hypoxic-ischemic injury in the rat brain. Neuroscience 70:1013-1024.
14. Lisman J, Malenka RC, Nicoll RA, Malinow R (1997) Learning mechanisms: The case for CaM-KII. Science 276:2001-2002.
15. Lisman JE, Zhabotinsky AM (2001) A model of synaptic memory: A CaMKII/PP1 switch that potentiates transmission by organizing an AMPA receptor anchoring assembly. Neuron 31:191-201.
16. Lledo PM, Hjelmstad GO, Mukherji S, Soderling TR, Malenka RC, Nicoll RA (1995) Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism. Proc Natl Acad Sci USA 92:11175-11179.
17. Malenka RC, Kauer JA, Perkel DJ, Mauk MD, Kelly PT, Nicoll RA, Waxham MN (1989) An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature 340:554-557.
18. Malinow R, Schulman H, Tsien RW (1989) Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science 245:862-866.
19. Marty S (2000) Differences in the regulation of neuropeptide Y, somatostatin and parvalbumin levels in hippocampal interneurons by neuronal activity and BDNF. Prog Brain Res 128:193-202.
20. Mayford M, Kandel ER (1999) Genetic approaches to memory storage. Trends Genet 15:463-470.
21. Mayford M, Wang J, Kandel ER, O'Dell TJ (1995) CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell 81:891-904.
22. Mayford M, Bach ME, Huang YY, Wang L, Hawkins RD, Kandel ER (1996) Control of memory formation through regulated expression of a CaMKII transgene. Science 274:1678-1683.
23. Ouyang Y, Kantor D, Harris KM, Schuman EM, Kennedy MB (1997) Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. J Neurosci 17:5416-5427.
24. Pettit DL, Perlman S, Malinow R (1994) Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons. Science 266:1881-1885.
25. Pikaart MJ, Recillas-Targa F, Felsenfeld G (1998) Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Genes Dev 12:2852-2862.
26. 2+ entry. J Neurosci 17:8169-8177.
27. Sandberg R, Yasuda R, Pankratz DG, Carter TA, Del Rio JA, Wodicka L, Mayford M, Lockhart DJ, Barlow C (2000) Regional and strain-specific gene expression mapping in the adult mouse brain. Proc Natl Acad Sci USA 97:11038-11043.
28. Silva AJ, Stevens CF, Tonegawa S, Wang Y (1992a) Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science 257:201-206.
29. Silva AJ, Paylor R, Wehner JM, Tonegawa S (1992b) Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 257:206-211.
30. Tretter YP, Munz B, Hubner G, ten Bruggencate G, Werner S, Alzheimer C (1996) Strong induction of activin expression after hippocampal lesion. NeuroReport 7:1819-1823.
31. Whittaker E, Vereker E, Lynch MA (1999) Neuropeptide Y inhibits glutamate release and long-term potentiation in rat dentate gyrus. Brain Res 827:229-233.