메뉴 건너뛰기




Volumn 56, Issue 3, 2002, Pages 354-368

Preclinical progress with CHF2819, a novel orally active acetylcholinesterase inhibitor

Author keywords

Acetylcholinesterase inhibitors; Alzheimer's disease; CHF2819; Neurotransmitters; Rat hippocampus

Indexed keywords

1,2,3,3A,8,8A HEXAHYDRO 1,3A,8 TRIMETHYLPYRROLO[2,3 B]INDOL 5 OL 2'ETHYLPHENYLCARBAMATE N OXIDE; 4 AMINOBUTYRIC ACID; ACETYLCHOLINE; ARGININE; ASPARTIC ACID; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CITRULLINE; DOPAMINE; GANSTIGMINE; GLUTAMIC ACID; NORADRENALIN; SCOPOLAMINE; SEROTONIN; TAURINE; UNCLASSIFIED DRUG;

EID: 0036660009     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10088     Document Type: Review
Times cited : (2)

References (107)
  • 2
    • 0023943181 scopus 로고
    • Differential alteration of various cholinergic-markers in cortical and subcortical regions of human brain in Alzheimer's disease
    • Araujo DM, Lapchak PA, Robitaille Y, Gauthier S, Quirion R. 1988. Differential alteration of various cholinergic-markers in cortical and subcortical regions of human brain in Alzheimer's disease. J Neurochem 50:1914-1923.
    • (1988) J Neurochem , vol.50 , pp. 1914-1923
    • Araujo, D.M.1    Lapchak, P.A.2    Robitaille, Y.3    Gauthier, S.4    Quirion, R.5
  • 3
    • 0344299274 scopus 로고    scopus 로고
    • Neuroprotective interaction effects of NMDA and AMPA receptor antagonists in an in vitro model of cerebral ischemia
    • Arias RL, Tasse JR, Bowlby MR. 1999. Neuroprotective interaction effects of NMDA and AMPA receptor antagonists in an in vitro model of cerebral ischemia. Brain Res 816:299-308.
    • (1999) Brain Res , vol.816 , pp. 299-308
    • Arias, R.L.1    Tasse, J.R.2    Bowlby, M.R.3
  • 4
    • 0022366461 scopus 로고
    • Pharmacokinetics of an anticholinesterasic agent (eserin N-oxide) in humans after administration of two galenic forms
    • Astier A, Petitjean D. 1985. Pharmacokinetics of an anticholinesterasic agent (eserin N-oxide) in humans after administration of two galenic forms. J Pharm Clin 4:521-527.
    • (1985) J Pharm Clin , vol.4 , pp. 521-527
    • Astier, A.1    Petitjean, D.2
  • 5
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus RT, Dean RL 3rd, Beer B, Lippa AS. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-414.
    • (1982) Science , vol.217 , pp. 408-414
    • Bartus, R.T.1    Dean R.L. III2    Beer, B.3    Lippa, A.S.4
  • 6
    • 0025167992 scopus 로고
    • Galanin immunoreactivity is increased in the nucleus basalis of Meynert in Alzheimer's disease
    • Beal MF, MacGarvey U, Swartz KJ. 1990. Galanin immunoreactivity is increased in the nucleus basalis of Meynert in Alzheimer's disease. Ann Neurol 28:157-161.
    • (1990) Ann Neurol , vol.28 , pp. 157-161
    • Beal, M.F.1    MacGarvey, U.2    Swartz, K.J.3
  • 7
    • 0022648169 scopus 로고
    • Noradrenergic modulation of cortical acethylcoline release in both direct and γ-aminobutyric acid-mediated
    • Beani L, Tanganelli S, Antonelli T, Bianchi C. 1986. Noradrenergic modulation of cortical acethylcoline release in both direct and γ-aminobutyric acid-mediated. J Pharmacol Exp Ther 236:230-236.
    • (1986) J Pharmacol Exp Ther , vol.236 , pp. 230-236
    • Beani, L.1    Tanganelli, S.2    Antonelli, T.3    Bianchi, C.4
  • 8
    • 0032972922 scopus 로고    scopus 로고
    • Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice
    • Begley JG, Duan W, Chan S, Duff K, Mattson MP. 1999. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J Neurochem 72:1030-1039.
    • (1999) J Neurochem , vol.72 , pp. 1030-1039
    • Begley, J.G.1    Duan, W.2    Chan, S.3    Duff, K.4    Mattson, M.P.5
  • 11
    • 0025011298 scopus 로고
    • Localization of nitric oxide synthase indicating a neural role for nitric oxide
    • Bredt DS, Hwang PM, Snyder SH. 1990. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768-770.
    • (1990) Nature , vol.347 , pp. 768-770
    • Bredt, D.S.1    Hwang, P.M.2    Snyder, S.H.3
  • 13
    • 0029970479 scopus 로고    scopus 로고
    • 2-adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat
    • 2-adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat. Psychopharmacology 124:347-354.
    • (1996) Psychopharmacology , vol.124 , pp. 347-354
    • Camacho, F.1    Smith, C.P.2    Vargas, H.M.3    Winslow, J.T.4
  • 14
    • 0027291657 scopus 로고
    • NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex
    • Carlson MD, Penney JB Jr, Young AB. 1993. NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex. Neurobiol Aging 14:343-352.
    • (1993) Neurobiol Aging , vol.14 , pp. 343-352
    • Carlson, M.D.1    Penney J.B., Jr.2    Young, A.B.3
  • 15
    • 0032797262 scopus 로고    scopus 로고
    • Nitric oxide synthases: Targets for therapeutic strategies in neurological diseases
    • Chabrier PE, Demerle-Pallardy C, Auguet M. 1999. Nitric oxide synthases: targets for therapeutic strategies in neurological diseases. Cell Mol Life Sci 55:1029-1035.
    • (1999) Cell Mol Life Sci , vol.55 , pp. 1029-1035
    • Chabrier, P.E.1    Demerle-Pallardy, C.2    Auguet, M.3
  • 16
    • 0024431682 scopus 로고
    • Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer type and in Parkinson's disease with and without dementia and depression
    • Chan-Palay V, Asan E. 1989. Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer type and in Parkinson's disease with and without dementia and depression. J Comp Neurol 287:373-392.
    • (1989) J Comp Neurol , vol.287 , pp. 373-392
    • Chan-Palay, V.1    Asan, E.2
  • 17
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi DW. 1988. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-634.
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 18
    • 0023641322 scopus 로고
    • Quantitative autoradiography of hippocampal GABAb and GABAa receptor changes in Alzheimer's disease
    • Chu DCM, Penney JB, Young AB. 1987. Quantitative autoradiography of hippocampal GABAb and GABAa receptor changes in Alzheimer's disease. Neurosci Lett 82:246-252.
    • (1987) Neurosci Lett , vol.82 , pp. 246-252
    • Chu, D.C.M.1    Penney, J.B.2    Young, A.B.3
  • 21
    • 0028960707 scopus 로고
    • Coadministration of cholinesterase inhibitors and idazoxan: Effects of neurotransmitters in rat cortex in vivo
    • Cuadra G, Giacobini E. 1995. Coadministration of cholinesterase inhibitors and idazoxan: effects of neurotransmitters in rat cortex in vivo. J Pharmacol Exp Ther 273:230-240.
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 230-240
    • Cuadra, G.1    Giacobini, E.2
  • 22
    • 0028341720 scopus 로고
    • Cholinesterase inhibitor effects on neurotransmitters in rat cortex in vivo
    • Cuadra G, Summers K, Giacobini E. 1994. Cholinesterase inhibitor effects on neurotransmitters in rat cortex in vivo. J Pharmacol Exp Ther 270:277-284.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 277-284
    • Cuadra, G.1    Summers, K.2    Giacobini, E.3
  • 23
    • 0033980910 scopus 로고    scopus 로고
    • Cholinesterase inhibitors: A new class of psychotropic compounds
    • Cummings JL. 2000. Cholinesterase inhibitors: A new class of psychotropic compounds. Am J Psychiatry 157:4-15.
    • (2000) Am J Psychiatry , vol.157 , pp. 4-15
    • Cummings, J.L.1
  • 24
    • 0029904327 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitors block acetylcholine-evoked release of dopamine in rat striatum in vivo
    • Dajas-Bailador F, Costa G, Emmett S, Bonilla C, Dajas F. 1996. Acetylcholinesterase inhibitors block acetylcholine-evoked release of dopamine in rat striatum in vivo. Brain Res 722:12-18.
    • (1996) Brain Res , vol.722 , pp. 12-18
    • Dajas-Bailador, F.1    Costa, G.2    Emmett, S.3    Bonilla, C.4    Dajas, F.5
  • 25
    • 0023696241 scopus 로고
    • Basal acetylcholine release in freely moving rats detected by online trans-striatal dialysis: Pharmacological aspects
    • Damsma G, Westerink BH, de Boer P, de Vries JB, Horn AS. 1988. Basal acetylcholine release in freely moving rats detected by online trans-striatal dialysis: Pharmacological aspects. Life Sci 43:1161-1168.
    • (1988) Life Sci , vol.43 , pp. 1161-1168
    • Damsma, G.1    Westerink, B.H.2    De Boer, P.3    De Vries, J.B.4    Horn, A.S.5
  • 26
    • 0033590969 scopus 로고    scopus 로고
    • Challenging the cholinergic hypothesis in Alzheimer disease
    • Davies P. 1999. Challenging the cholinergic hypothesis in Alzheimer disease. JAMA 281:1433-1434.
    • (1999) JAMA , vol.281 , pp. 1433-1434
    • Davies, P.1
  • 27
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies P, Maloney AJ. 1976. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2:1403.
    • (1976) Lancet , vol.2 , pp. 1403
    • Davies, P.1    Maloney, A.J.2
  • 28
    • 0026621185 scopus 로고
    • Dopaminergic regulation of cortical acetylcholine release
    • Day J, Fibiger HC. 1992. Dopaminergic regulation of cortical acetylcholine release. Synapse 12:281-286.
    • (1992) Synapse , vol.12 , pp. 281-286
    • Day, J.1    Fibiger, H.C.2
  • 29
    • 0025196134 scopus 로고
    • The effect of acetylcholinesterase inhibition on the release of acetylcholine from the striatum in vivo: Interaction with autoreceptor responses
    • de Boer P, Westerink BH, Horn AS. 1990. The effect of acetylcholinesterase inhibition on the release of acetylcholine from the striatum in vivo: interaction with autoreceptor responses. Neurosci Lett 116:357-360.
    • (1990) Neurosci Lett , vol.116 , pp. 357-360
    • De Boer, P.1    Westerink, B.H.2    Horn, A.S.3
  • 30
    • 0025851708 scopus 로고
    • The role of interactions between cholinergic systems and other neuromodulatory systems in learning and memory
    • Decker MW, McGaugh JL. 1991. The role of interactions between cholinergic systems and other neuromodulatory systems in learning and memory. Synapse 7:151-168.
    • (1991) Synapse , vol.7 , pp. 151-168
    • Decker, M.W.1    McGaugh, J.L.2
  • 31
    • 0001904082 scopus 로고
    • The cholinergic synapse and the site of memory
    • Deutsch JA, editor. New York: Academic Press
    • Deutsch JA. 1973. The cholinergic synapse and the site of memory. In: Deutsch JA, editor. The physiological basis of memory. New York: Academic Press. p 13-16.
    • (1973) The physiological basis of memory , pp. 13-16
    • Deutsch, J.A.1
  • 32
    • 0025785213 scopus 로고
    • Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: An autoradiographic study of the hippocampus
    • Dewar D, Chalmers DT, Graham DI, McCulloch J. 1991. Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus. Brain Res 553:58-64.
    • (1991) Brain Res , vol.553 , pp. 58-64
    • Dewar, D.1    Chalmers, D.T.2    Graham, D.I.3    McCulloch, J.4
  • 33
    • 0032749775 scopus 로고    scopus 로고
    • A multicentre, randomized, double-blind, placebo-controlled study to evaluate the efficacy, tolerability and safety of two doses of metrifonate in patients with mild-to-moderate Alzheimer's disease: The MALT study
    • Dubois B, McKeith I, Orgogozo JM, Collins O, Meulien D. 1999. A multicentre, randomized, double-blind, placebo-controlled study to evaluate the efficacy, tolerability and safety of two doses of metrifonate in patients with mild-to-moderate Alzheimer's disease: the MALT study. Int J Geriat Psychiatry 14:973-982.
    • (1999) Int J Geriat Psychiatry , vol.14 , pp. 973-982
    • Dubois, B.1    McKeith, I.2    Orgogozo, J.M.3    Collins, O.4    Meulien, D.5
  • 35
    • 0001972906 scopus 로고
    • Terry RD, Catsman R, Bick KL editors. New York: Raven Press
    • Folstein MF, Bylsma FW. 1994. In: Terry RD, Catsman R, Bick KL editors. Alzheimer's Disease. New York: Raven Press. p 27-40.
    • (1994) Alzheimer's Disease , pp. 27-40
    • Folstein, M.F.1    Bylsma, F.W.2
  • 36
    • 84937174324 scopus 로고
    • Alzheimer's disease: Clinical features and differential diagnosis
    • Friedland RP. 1993. Alzheimer's disease: clinical features and differential diagnosis. Neurology 43:S45-S51.
    • (1993) Neurology , vol.43
    • Friedland, R.P.1
  • 38
    • 0002037940 scopus 로고
    • Cholinergic systems and related neuropathological predilection patterns in Alzheimer disease
    • Terry RD, Katzman R, Bick KL editors. New York: Raven Press
    • Geula C, Mesulam MM. 1994. Cholinergic systems and related neuropathological predilection patterns in Alzheimer disease. In: Terry RD, Katzman R, Bick KL editors. Alzheimer's Disease. New York: Raven Press. p 263-291.
    • (1994) Alzheimer's Disease , pp. 263-291
    • Geula, C.1    Mesulam, M.M.2
  • 39
    • 0029937950 scopus 로고    scopus 로고
    • The effect of the selective reversible acetylcholinesterase inhibitor E2020 on extracellular acetylcholine and biogenic amine levels in rat cortex
    • Giacobini E, Zhu XD, Williams E, Sherman KA. 1996. The effect of the selective reversible acetylcholinesterase inhibitor E2020 on extracellular acetylcholine and biogenic amine levels in rat cortex. Neuropharmacology 35:205-211.
    • (1996) Neuropharmacology , vol.35 , pp. 205-211
    • Giacobini, E.1    Zhu, X.D.2    Williams, E.3    Sherman, K.A.4
  • 40
    • 0025081761 scopus 로고
    • Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer's dementia
    • Gottfries CG. 1990. Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer's dementia. J Neural Transm (Suppl) 30:33-43.
    • (1990) J Neural Transm (Suppl) , vol.30 , pp. 33-43
    • Gottfries, C.G.1
  • 41
    • 0002279402 scopus 로고    scopus 로고
    • Depression and Alzheimer's disease
    • Becker R, Giacobini E, editors. Boston: Birkäuser
    • Gottfries CG. 1996. Depression and Alzheimer's disease. In: Becker R, Giacobini E, editors. Alzheimer disease: from molecular biology to therapy. Boston: Birkäuser. p 495-499.
    • (1996) Alzheimer disease: From molecular biology to therapy , pp. 495-499
    • Gottfries, C.G.1
  • 43
    • 0028894072 scopus 로고
    • Phenserine and ring C hetero-analogues: Drug candidates for the treatment of Alzheimer's disease
    • Greig NH, Pei XF, Soncrant TT, Ingram DK, Brossi A. 1995. Phenserine and ring C hetero-analogues: drug candidates for the treatment of Alzheimer's disease. Med Res Rev 15:3-31.
    • (1995) Med Res Rev , vol.15 , pp. 3-31
    • Greig, N.H.1    Pei, X.F.2    Soncrant, T.T.3    Ingram, D.K.4    Brossi, A.5
  • 44
    • 0026663254 scopus 로고
    • Nicotinic and muscarinic components of rat brain dopamine synthesis stimulation induced by physostigmine
    • Grenhoff J, Svensson TH. 1992. Nicotinic and muscarinic components of rat brain dopamine synthesis stimulation induced by physostigmine. Naunyn-Schmiedeberg's Arch Pharmacol 346:395-398.
    • (1992) Naunyn-Schmiedeberg's Arch Pharmacol , vol.346 , pp. 395-398
    • Grenhoff, J.1    Svensson, T.H.2
  • 45
    • 0025015519 scopus 로고
    • Implications of multiple transmitter system lesions for cholinomimetic therapy in Alzheimer's disease
    • Haroutunian V, Santucci AC, Davis KL. 1990. Implications of multiple transmitter system lesions for cholinomimetic therapy in Alzheimer's disease. Prog Brain Res 84:333-346.
    • (1990) Prog Brain Res , vol.84 , pp. 333-346
    • Haroutunian, V.1    Santucci, A.C.2    Davis, K.L.3
  • 46
    • 0024545260 scopus 로고
    • Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type
    • Hoyer S, Nitsch R. 1989. Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type. J Neural Transm 75:227-232.
    • (1989) J Neural Transm , vol.75 , pp. 227-232
    • Hoyer, S.1    Nitsch, R.2
  • 47
    • 0023270663 scopus 로고
    • Alzheimer's disease: Glutamate depletion in the hippocampal perforant pathway zone
    • Hyman BT, Van Hoesen GW, Damasio AR. 1987. Alzheimer's disease: glutamate depletion in the hippocampal perforant pathway zone. Ann Neurol 22:37-40.
    • (1987) Ann Neurol , vol.22 , pp. 37-40
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3
  • 49
    • 0035012753 scopus 로고    scopus 로고
    • Pharmacodynamic-tolerability relationships of cholinesterase inhibitors for Alzheimer's disease
    • Imbimbo BP. 2001. Pharmacodynamic-tolerability relationships of cholinesterase inhibitors for Alzheimer's disease. CNS Drugs 15:375-390.
    • (2001) CNS Drugs , vol.15 , pp. 375-390
    • Imbimbo, B.P.1
  • 50
    • 0033541027 scopus 로고    scopus 로고
    • Efficacy and safety of eptastigmine for the treatment of patients with Alzheimer's disease
    • Imbimbo BP, Martelli P, Troetel WM, Lucchelli F, Lucca U, Thal LJ. 1999. Efficacy and safety of eptastigmine for the treatment of patients with Alzheimer's disease. Neurology 52:700-708.
    • (1999) Neurology , vol.52 , pp. 700-708
    • Imbimbo, B.P.1    Martelli, P.2    Troetel, W.M.3    Lucchelli, F.4    Lucca, U.5    Thal, L.J.6
  • 52
    • 0026331235 scopus 로고
    • Determination of acetylcholine release in the striatum of anesthetized rats using in vivo microdialysis and a radioimmunoassay
    • Kawashima K, Hayakawa T, Kashima Y, Suzuki T, Fujimoto K, Oohata H. 1991. Determination of acetylcholine release in the striatum of anesthetized rats using in vivo microdialysis and a radioimmunoassay. J Neurochem 57:882-887.
    • (1991) J Neurochem , vol.57 , pp. 882-887
    • Kawashima, K.1    Hayakawa, T.2    Kashima, Y.3    Suzuki, T.4    Fujimoto, K.5    Oohata, H.6
  • 53
    • 0033118413 scopus 로고    scopus 로고
    • Alzheimer's disease: The tacrine legacy
    • Kelly JS. 1999. Alzheimer's disease: the tacrine legacy. Trends Pharmacol Sci 20:127-129.
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 127-129
    • Kelly, J.S.1
  • 54
    • 0030475924 scopus 로고    scopus 로고
    • NMDA and Kainate-evoked release of nitric oxide and classical transmitters in the rat striatum: In vivo evidence that nitric oxide may play a neuroprotective role
    • KendricK KM, Guevara-Guzman R, de la Riva C, Christensen J, Ostergaard K, Emson P. 1996. NMDA and Kainate-evoked release of nitric oxide and classical transmitters in the rat striatum: in vivo evidence that nitric oxide may play a neuroprotective role. Eur J Neurosci 8:2619-2634.
    • (1996) Eur J Neurosci , vol.8 , pp. 2619-2634
    • KendricK, K.M.1    Guevara-Guzman, R.2    De la Riva, C.3    Christensen, J.4    Ostergaard, K.5    Emson, P.6
  • 55
    • 0028270519 scopus 로고
    • A 30-week randomized controlled trial of highdose tacrine in patients with Alzheimer's disease
    • The Tacrine Study Group
    • Knapp MJ, Knopman DS, Solomon PR, Pendlebury WW, Davis CS, Gracon SI. 1994. A 30-week randomized controlled trial of highdose tacrine in patients with Alzheimer's disease. The Tacrine Study Group. JAMA 271:985-991.
    • (1994) JAMA , vol.271 , pp. 985-991
    • Knapp, M.J.1    Knopman, D.S.2    Solomon, P.R.3    Pendlebury, W.W.4    Davis, C.S.5    Gracon, S.I.6
  • 56
    • 0025110182 scopus 로고
    • Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage
    • Koh JY, Yang LL, Cotman CW. 1990. Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res 533:315-320.
    • (1990) Brain Res , vol.533 , pp. 315-320
    • Koh, J.Y.1    Yang, L.L.2    Cotman, C.W.3
  • 57
    • 0032948006 scopus 로고    scopus 로고
    • Peroxynitrite-induced alterations in synaptosomal membrane proteins: Insight into oxidative stress in Alzheimer's disease
    • Koppal T, Drake J, Yatin S, Jordan B, Varadarajan S, Bettenhausen L, Butterfield DA. 1999. Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease. J Neurochem 72:310-317.
    • (1999) J Neurochem , vol.72 , pp. 310-317
    • Koppal, T.1    Drake, J.2    Yatin, S.3    Jordan, B.4    Varadarajan, S.5    Bettenhausen, L.6    Butterfield, D.A.7
  • 58
    • 0026078330 scopus 로고
    • Glutamate-, glutaminase-, and taurine-immunoreactive neurons develop neurofibrillay tangles in Alzheimer's disease
    • Kowall NW, Beal MF. 1991. Glutamate-, glutaminase-, and taurine-immunoreactive neurons develop neurofibrillay tangles in Alzheimer's disease. Ann Neurol 29:162-167.
    • (1991) Ann Neurol , vol.29 , pp. 162-167
    • Kowall, N.W.1    Beal, M.F.2
  • 59
    • 0035105932 scopus 로고    scopus 로고
    • Say NO to Alzheimer's disease: The putative links between nitric oxide and dementia of the Alzheimer's type
    • Law A, Gauthier S, Quirion R. 2001. Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type. Brain Res Brain Res Rev 35:73-96.
    • (2001) Brain Res Brain Res Rev , vol.35 , pp. 73-96
    • Law, A.1    Gauthier, S.2    Quirion, R.3
  • 60
    • 0025054474 scopus 로고
    • Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease
    • Lowe SL, Bowen DM, Francis PT, Neary D. 1990. Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease. Neuroscience 38:571-577.
    • (1990) Neuroscience , vol.38 , pp. 571-577
    • Lowe, S.L.1    Bowen, D.M.2    Francis, P.T.3    Neary, D.4
  • 62
    • 0029811226 scopus 로고    scopus 로고
    • Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease
    • Masliah E, Alford M, DeTeresa R, Mallory M, Hansen L. 1996. Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann Neurol 40:759-766.
    • (1996) Ann Neurol , vol.40 , pp. 759-766
    • Masliah, E.1    Alford, M.2    DeTeresa, R.3    Mallory, M.4    Hansen, L.5
  • 63
    • 0027337416 scopus 로고
    • Brain banks and research in neurochemistry
    • May N. 1993. Brain banks and research in neurochemistry. J Neural Transm 39:119-126.
    • (1993) J Neural Transm , vol.39 , pp. 119-126
    • May, N.1
  • 64
    • 0023900256 scopus 로고
    • Acute scopolamine treatment decreases dopamine metabolism in rat hippocampus and frontal cortex
    • Memo M, Missale C, Trivelli L, Spano PF. 1988. Acute scopolamine treatment decreases dopamine metabolism in rat hippocampus and frontal cortex. Eur J Pharmacol 149:367-370.
    • (1988) Eur J Pharmacol , vol.149 , pp. 367-370
    • Memo, M.1    Missale, C.2    Trivelli, L.3    Spano, P.F.4
  • 65
    • 0027502112 scopus 로고
    • Cholinesterase inhibitor effects on extracellular acetylcholine in rat striatum
    • Messamore E, Ogane N, Giacobini E. 1993. Cholinesterase inhibitor effects on extracellular acetylcholine in rat striatum. Neuropharmacology 32:291-296.
    • (1993) Neuropharmacology , vol.32 , pp. 291-296
    • Messamore, E.1    Ogane, N.2    Giacobini, E.3
  • 66
    • 0028842909 scopus 로고
    • Metrifonate effects on acetylcholine and biogenic amines in rat cortex
    • Mori F, Cuadra G, Giacobini E. 1995. Metrifonate effects on acetylcholine and biogenic amines in rat cortex. Neurochem Res 20:1081-1088.
    • (1995) Neurochem Res , vol.20 , pp. 1081-1088
    • Mori, F.1    Cuadra, G.2    Giacobini, E.3
  • 67
    • 0031308066 scopus 로고    scopus 로고
    • Neurobehavioral screening battery
    • Moser VC. 1997. Neurobehavioral screening battery. Neurotoxicology 18:923-1083.
    • (1997) Neurotoxicology , vol.18 , pp. 923-1083
    • Moser, V.C.1
  • 69
    • 0024818025 scopus 로고
    • Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes
    • Nielsen JA, Mena EE, Williams IH, Nocerini MR, Liston D. 1989. Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes. Eur J Pharmacol 173:53-64.
    • (1989) Eur J Pharmacol , vol.173 , pp. 53-64
    • Nielsen, J.A.1    Mena, E.E.2    Williams, I.H.3    Nocerini, M.R.4    Liston, D.5
  • 70
    • 0022912438 scopus 로고
    • Muscarinic receptor subtypes in hippocampus in Alzheimer's disease and mixed dementia type
    • Nordberg A, Alafuzoff I, Winblad B. 1986. Muscarinic receptor subtypes in hippocampus in Alzheimer's disease and mixed dementia type. Neurosci Lett 70:160-164.
    • (1986) Neurosci Lett , vol.70 , pp. 160-164
    • Nordberg, A.1    Alafuzoff, I.2    Winblad, B.3
  • 71
    • 0025244327 scopus 로고
    • The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disordes. A Nordic multicentre study
    • Nyth AL, Gottfries CG. 1990. The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disordes. A Nordic multicentre study. Br J Psychiatry 157:894-901.
    • (1990) Br J Psychiatry , vol.157 , pp. 894-901
    • Nyth, A.L.1    Gottfries, C.G.2
  • 72
    • 0002871513 scopus 로고    scopus 로고
    • Preclinical pharmacology of cholinesterase inhibitors
    • Giacobini E, editor. London: Martin Dunitz Publishers
    • Pepeu G. 2000. Preclinical pharmacology of cholinesterase inhibitors. In: Giacobini E, editor. Cholinesterases and cholinesterase inhibitors. London: Martin Dunitz Publishers. p 145-155.
    • (2000) Cholinesterases and cholinesterase inhibitors , pp. 145-155
    • Pepeu, G.1
  • 73
    • 0031443126 scopus 로고    scopus 로고
    • Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: New insights into the mechanism of action in the inhibition of acetylcholinesterase
    • Perola E, Cellai L, Lambda D, Filocamo L, Brufani M. 1997. Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase. Biochim Biophys Acta 1343:41-50.
    • (1997) Biochim Biophys Acta , vol.1343 , pp. 41-50
    • Perola, E.1    Cellai, L.2    Lambda, D.3    Filocamo, L.4    Brufani, M.5
  • 74
    • 0022645755 scopus 로고
    • The cholinergic hypothesis-ten years on
    • Perry EK. 1986. The cholinergic hypothesis-ten years on. Br Med Bull 42:63-69.
    • (1986) Br Med Bull , vol.42 , pp. 63-69
    • Perry, E.K.1
  • 75
    • 0002213031 scopus 로고    scopus 로고
    • Cholinesterase inhibitory activity of new geneserine derivatives
    • Iqbal K, Swaab DF, Winblad B, Wisniewski HM, editors. New York: John Wiley & Sons
    • Pietra C, Villetti G, Bolzoni PT, Delcanale M, Amari G, Caruso P, Civelli M. 1999. Cholinesterase inhibitory activity of new geneserine derivatives. In: Iqbal K, Swaab DF, Winblad B, Wisniewski HM, editors. Alzheimer's Disease and Related Disorders. New York: John Wiley & Sons. p 689-696.
    • (1999) Alzheimer's Disease and Related Disorders , pp. 689-696
    • Pietra, C.1    Villetti, G.2    Bolzoni, P.T.3    Delcanale, M.4    Amari, G.5    Caruso, P.6    Civelli, M.7
  • 76
    • 0033958462 scopus 로고    scopus 로고
    • Glutamate excitotoxicity in a model of multiple sclerosis
    • Pitt D, Werner P, Raine CS. 2000. Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med 6:67-70.
    • (2000) Nat Med , vol.6 , pp. 67-70
    • Pitt, D.1    Werner, P.2    Raine, C.S.3
  • 77
    • 0027718062 scopus 로고
    • Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release
    • Quirion R. 1993. Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release. J Psychiatry Neurosci 18:226-234.
    • (1993) J Psychiatry Neurosci , vol.18 , pp. 226-234
    • Quirion, R.1
  • 78
    • 0033060809 scopus 로고    scopus 로고
    • The effects of metrifonate on the cognitive, behavioral, and functional performance of Alzheimer's disease patients
    • Metrifonate Study Group
    • Raskind MA, Cyrus PA, Ruzicka BB, Gulanski BI. 1999. The effects of metrifonate on the cognitive, behavioral, and functional performance of Alzheimer's disease patients. Metrifonate Study Group. J Clin Psychiatry 60:318-325.
    • (1999) J Clin Psychiatry , vol.60 , pp. 318-325
    • Raskind, M.A.1    Cyrus, P.A.2    Ruzicka, B.B.3    Gulanski, B.I.4
  • 79
    • 0014375345 scopus 로고
    • The anti-cholinesterase activities of the alkaloids of Physostigma venenosum seeds
    • Robinson B, Robinson JB. 1968. The anti-cholinesterase activities of the alkaloids of Physostigma venenosum seeds. J Pharm Pharmacol 20:213-217.
    • (1968) J Pharm Pharmacol , vol.20 , pp. 213-217
    • Robinson, B.1    Robinson, J.B.2
  • 80
    • 0024835059 scopus 로고
    • The mechanism of tetrahydroaminoacridine-evoked release of endogenous 5-hydroxytryptamine and dopamine from rat brain tissue prisms
    • Robinson TN, de Souza RJ, Cross AJ, Green AR. 1989. The mechanism of tetrahydroaminoacridine-evoked release of endogenous 5-hydroxytryptamine and dopamine from rat brain tissue prisms. Br J Pharmacol 98:1127-1136.
    • (1989) Br J Pharmacol , vol.98 , pp. 1127-1136
    • Robinson, T.N.1    De Souza, R.J.2    Cross, A.J.3    Green, A.R.4
  • 81
    • 0022401271 scopus 로고
    • Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease
    • Rogers J, Morrison JH. 1985. Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease. J Neurosci 5:2801-2808.
    • (1985) J Neurosci , vol.5 , pp. 2801-2808
    • Rogers, J.1    Morrison, J.H.2
  • 84
    • 0031443044 scopus 로고    scopus 로고
    • Tacrine administration enhances extracellular acetylcholine in vivo and restores the cognitive impairment in aged rats
    • Scali C, Giovannini MG, Prosperi C, Bartolini L, Pepeu G. 1997b. Tacrine administration enhances extracellular acetylcholine in vivo and restores the cognitive impairment in aged rats. Pharmacol Res 36:463-469.
    • (1997) Pharmacol Res , vol.36 , pp. 463-469
    • Scali, C.1    Giovannini, M.G.2    Prosperi, C.3    Bartolini, L.4    Pepeu, G.5
  • 85
    • 0031925575 scopus 로고    scopus 로고
    • Cholinergic deficiency in Alzheimer's disease. Pathogenic model
    • Schneider LS. 1998. Cholinergic deficiency in Alzheimer's disease. Pathogenic model. Am J Geriatr Psychiatry 6(Suppl 1):S49-55.
    • (1998) Am J Geriatr Psychiatry , vol.6 , Issue.SUPPL. 1
    • Schneider, L.S.1
  • 86
    • 0035021197 scopus 로고    scopus 로고
    • Treatment of Alzheimer's disease with cholinesterase inhibitors
    • Schneider LS. 2001. Treatment of Alzheimer's disease with cholinesterase inhibitors. Clin Geriatr Med 17:337-358.
    • (2001) Clin Geriatr Med , vol.17 , pp. 337-358
    • Schneider, L.S.1
  • 87
    • 0028903337 scopus 로고
    • The efficacy of cholinergic drugs in patients with Alzheimer's disease-Focus on the aminoacridines
    • Siegfried K. 1995. The efficacy of cholinergic drugs in patients with Alzheimer's disease-Focus on the aminoacridines. Hum Psychopharmacol 10:89-96.
    • (1995) Hum Psychopharmacol , vol.10 , pp. 89-96
    • Siegfried, K.1
  • 88
    • 0025607117 scopus 로고
    • Nicotinic acetylcholine receptor subtypes in human frontal cortex: Changes in Alzheimer's disease
    • Sugaya K, Giacobini E, Chiappinelli VA. 1990. Nicotinic acetylcholine receptor subtypes in human frontal cortex: changes in Alzheimer's disease. J Neurosci Res 27:349-359.
    • (1990) J Neurosci Res , vol.27 , pp. 349-359
    • Sugaya, K.1    Giacobini, E.2    Chiappinelli, V.A.3
  • 89
    • 0030855949 scopus 로고    scopus 로고
    • Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E. genotypes
    • Svensson AL, Warpman U, Hellstrom-Lindahl E, Bogdanovic N, Lannfelt L, Nordberg A. 1997. Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E. genotypes. Neurosci Lett 232:37-40.
    • (1997) Neurosci Lett , vol.232 , pp. 37-40
    • Svensson, A.L.1    Warpman, U.2    Hellstrom-Lindahl, E.3    Bogdanovic, N.4    Lannfelt, L.5    Nordberg, A.6
  • 90
    • 0034720864 scopus 로고    scopus 로고
    • A 5-month, randomized placebo-controlled trial of galantamine in AD
    • The Galantamine USA-10 Study Group
    • Tariot PN, Solomon PR, Morris JC, Kershaw P, Lilienfeld S, Ding C. 2000. A 5-month, randomized placebo-controlled trial of galantamine in AD. The Galantamine USA-10 Study Group. Neurology 54:2269-2276.
    • (2000) Neurology , vol.54 , pp. 2269-2276
    • Tariot, P.N.1    Solomon, P.R.2    Morris, J.C.3    Kershaw, P.4    Lilienfeld, S.5    Ding, C.6
  • 91
    • 0032921029 scopus 로고    scopus 로고
    • A 24-week randomized trial of controlled-release physostigmine in patients with Alzheimer's disease
    • Thal LJ, Ferguson JM, Mintzer J, Raskin A, Targum SD. 1999. A 24-week randomized trial of controlled-release physostigmine in patients with Alzheimer's disease. Neurology 52:1146-1152.
    • (1999) Neurology , vol.52 , pp. 1146-1152
    • Thal, L.J.1    Ferguson, J.M.2    Mintzer, J.3    Raskin, A.4    Targum, S.D.5
  • 93
    • 0033818302 scopus 로고    scopus 로고
    • Nitric oxide can differentially modulate striatal neurotransmitter concentrazione via soluble guanylate cyclase and peroxynitrite formation
    • Trabace L, Kendrick KM. 2000. Nitric oxide can differentially modulate striatal neurotransmitter concentrazione via soluble guanylate cyclase and peroxynitrite formation. J Neurochem 75:1664-1674.
    • (2000) J Neurochem , vol.75 , pp. 1664-1674
    • Trabace, L.1    Kendrick, K.M.2
  • 94
    • 0033934884 scopus 로고    scopus 로고
    • Biochemical and neurobehavioral profile of CHF2819, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's Disease
    • Trabace L, Cassano T, Steardo L, Pietra C, Villetti G, Kendrick K, Cuomo V. 2000a. Biochemical and neurobehavioral profile of CHF2819, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's Disease. J Pharmacol Exp Ther 294:187-194.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 187-194
    • Trabace, L.1    Cassano, T.2    Steardo, L.3    Pietra, C.4    Villetti, G.5    Kendrick, K.6    Cuomo, V.7
  • 97
    • 0036076758 scopus 로고    scopus 로고
    • CHF2819: Pharmacological profile of a novel acetylcholinesterase inhibitor
    • Trabace L, Cassano T, Loverre A, Steardo L, Cuomo V. 2002. CHF2819: pharmacological profile of a novel acetylcholinesterase inhibitor. CNS Drug Rev 8:53-69.
    • (2002) CNS Drug Rev , vol.8 , pp. 53-69
    • Trabace, L.1    Cassano, T.2    Loverre, A.3    Steardo, L.4    Cuomo, V.5
  • 98
    • 0030839413 scopus 로고    scopus 로고
    • Cholinergic basal forebrain projections to nitric oxide synthase-containing neurons in the rat cerebral cortex
    • Vaucher E, Linville D, Hamel E. 1997. Cholinergic basal forebrain projections to nitric oxide synthase-containing neurons in the rat cerebral cortex. Neuroscience 79:827-836.
    • (1997) Neuroscience , vol.79 , pp. 827-836
    • Vaucher, E.1    Linville, D.2    Hamel, E.3
  • 99
    • 0032557464 scopus 로고    scopus 로고
    • Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: Comparison with E2020 and tacrine
    • Wang T, Tang C. 1998. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. Eur J Pharmacol 349:137-142.
    • (1998) Eur J Pharmacol , vol.349 , pp. 137-142
    • Wang, T.1    Tang, C.2
  • 100
    • 0030431372 scopus 로고    scopus 로고
    • Effect of tacrine on in vivo release of dopamine and its metabolites in the striatum of freely moving rats
    • Warpman U, Zhang X, Nordberg A. 1996. Effect of tacrine on in vivo release of dopamine and its metabolites in the striatum of freely moving rats. J Pharmacol Exp Ther 277:917-922.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 917-922
    • Warpman, U.1    Zhang, X.2    Nordberg, A.3
  • 101
    • 0026023082 scopus 로고
    • Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures
    • Welsh K, Butters N, Hughes J, Mohs R, Heyman A. 1991. Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures. Arch Neurol 48:278-281.
    • (1991) Arch Neurol , vol.48 , pp. 278-281
    • Welsh, K.1    Butters, N.2    Hughes, J.3    Mohs, R.4    Heyman, A.5
  • 103
    • 0034627263 scopus 로고    scopus 로고
    • Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: Multicentre randomised controlled trial
    • Galantamine International-1 Study Group
    • Wilcock GK, Lilienfeld S, Gaens E. 2000. Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial. Galantamine International-1 Study Group. BMJ 321:1445-1449.
    • (2000) BMJ , vol.321 , pp. 1445-1449
    • Wilcock, G.K.1    Lilienfeld, S.2    Gaens, E.3
  • 105
    • 0024473964 scopus 로고
    • Differential effects of M1 and M2-muscarinic drugs on striatal dopamine release and metabolism in freely moving rats
    • Xu M, Mizobe F, Yamamoto T, Kato T. 1989. Differential effects of M1 and M2-muscarinic drugs on striatal dopamine release and metabolism in freely moving rats. Brain Res 495:232-242.
    • (1989) Brain Res , vol.495 , pp. 232-242
    • Xu, M.1    Mizobe, F.2    Yamamoto, T.3    Kato, T.4
  • 106
    • 0024314648 scopus 로고
    • A brain regional analysis of morphologic and cholinergic abnormalities in Alzheimer's disease
    • Zubenko GS, Moossy J, Martinez AJ, Rao GR, Kopp U, Hanin I. 1989. A brain regional analysis of morphologic and cholinergic abnormalities in Alzheimer's disease. Arch Neurol 46:634-638.
    • (1989) Arch Neurol , vol.46 , pp. 634-638
    • Zubenko, G.S.1    Moossy, J.2    Martinez, A.J.3    Rao, G.R.4    Kopp, U.5    Hanin, I.6
  • 107
    • 0025058707 scopus 로고
    • Neurochemical correlates of major depression in primary dementia
    • Zubenko GS, Mossy J, Kopp U. 1990. Neurochemical correlates of major depression in primary dementia. Arch Neurol 47:209-214.
    • (1990) Arch Neurol , vol.47 , pp. 209-214
    • Zubenko, G.S.1    Mossy, J.2    Kopp, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.