Central cholinergic challenging of migraine by testing second-generation anticholinesterase drugs

Headache

Volumn 42, Issue 7, 2002, Pages 596-602

  Nicolodi, M ^a   Galeotti, N ^b   Ghelardini, C ^b   Bartolini, A ^b   Sicuteri, F ^a  

^a Neurochemistry and Clinical Pharmacology of Idiopathic Headache   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Analgesia; Central cholinergic system; Cholinesterase inhibitor; Donepezil; Migraine; Primary pain; Prophylaxis

Indexed keywords

ANTIMIGRAINE AGENT; CHOLINESTERASE INHIBITOR; DONEPEZIL; PROPRANOLOL; SCOPOLAMINE;

ADULT; ANIMAL BEHAVIOR; ANTINOCICEPTION; ANXIETY NEUROSIS; ARTICLE; ASTHENIA; BRADYCARDIA; CHOLINERGIC SYSTEM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOSE TIME EFFECT RELATION; DROWSINESS; DRUG ANTAGONISM; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; GENERAL PRACTICE; HOT PLATE TEST; HUMAN; MAJOR CLINICAL STUDY; MALE; MIGRAINE; MOUSE; NAUSEA; NIGHTMARE; NONHUMAN; PAIN ASSESSMENT; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROPHYLAXIS; REM SLEEP; SELF ESTEEM; SEXUAL DYSFUNCTION; SIDE EFFECT; SLEEP DISORDER; SLEEP TIME; VOMITING;

ADRENERGIC BETA-ANTAGONISTS; ADULT; ANALGESICS; ANIMALS; ANXIETY; CENTRAL NERVOUS SYSTEM; CHOLINESTERASE INHIBITORS; FEMALE; HUMANS; INDANS; MALE; MICE; MIGRAINE DISORDERS; NAUSEA; PIPERIDINES; PROPRANOLOL; SLEEP, REM; TIME FACTORS; TREATMENT OUTCOME; VOMITING;

EID: 0036656622     PISSN: 00178748     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1526-4610.2002.02146.x     Document Type: Article

References (18)

1. The serotonin theory of migraine
2. A central biochemical disnociception
3. 3 agonists decrease acetylcholine efflux from the cerebral cortex of freely moving guinea-pigs
4. The central cholinergic system has a role in the antinociception induced in rodents and guinea pigs by the antimigraine drug sumatriptan
5. La geneserine-morphine adjuvant de l'anesthesia generale
6. Antinociceptive effects of intrathecally injected cholinomimetic drugs in the rat and cat
7. Antinociceptive effect of spinal cholinergic stimulation: Interaction with substance P
8. 2 receptor systems
9. 1 receptors
10. Migraine prophylaxys by brain cholinesterase inhibitors
11. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl) methyl] piperidine hydrochloride (E2020) and related compounds
12. Donepezil improves cognition and global function in Alzheimer disease
13. Antimigraine drugs
14. Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure
15. A self rating depression scale
16. Brief anxiety rating test
17. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain
18. Antinociception induced by systemic administration of local anaesthetics depends on a central cholinergic mechanism