Non-linear mixed effects modeling of sparse concentration data from rats: Application to a glycogen phosphorylase inhibitor

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 27, Issue 3, 2002, Pages 203-212

  Ingwersen, Steen H ^a   Kiehr, Benedicte ^a   Iversen, Lars ^a   Andersen, Michael P ^a   Petersen, Yvonne ^a   Rytved, Klaus A ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

Population pharmacokinetics; Preclinical; Rat; Sparse sampling approach; Toxicokinetics

Indexed keywords

1,4 DIDEOXY 1,4 IMINO DEXTRO ARABINITOL; ARABINITOL; ENZYME INHIBITOR; GLYCOGEN PHOSPHORYLASE; GLYCOGEN PHOSPHORYLASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG SAFETY; DRUG TRANSPORT; EXPERIMENTAL MODEL; FEMALE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GLYCOGEN PHOSPHORYLASE; MALE; NONLINEAR DYNAMICS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036655750     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190459     Document Type: Article

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