Testing for genetic associations in a spina bifida population: Analysis of the HOX gene family and human candidate gene regions implicated by mouse models of neural tube defects

American Journal of Medical Genetics

Volumn 110, Issue 3, 2002, Pages 203-207

  Volcik, K A ^a   Blanton, S H ^b   Kruzel, M C ^a   Townsend, I T ^a   Tyerman, G H ^c   Mier, R J ^d   Northrup, H ^a,e  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c SHRINERS HOSPITALS FOR CHILDREN   (United States)

^d Shriners Hospital for Children   (United States)

^e Shriners Hospital for Children   (United States)

Author keywords

HOX genes; Mouse models; Neural tube defects (NTDs); Spina bifida (SB); Transmission disequilibrium test (TDT)

Indexed keywords

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; HOX GENE; HUMAN; MAJOR CLINICAL STUDY; MOUSE; MULTIFACTORIAL GENETIC DISORDER; NEURAL TUBE DEFECT; NONHUMAN; POPULATION GENETICS; PRIORITY JOURNAL; SPINA BIFIDA; STRAIN DIFFERENCE; SYNTENY; UNITED STATES;

ADOLESCENT; ADULT; ALLELES; ANIMALS; CHILD; CHILD, PRESCHOOL; DISEASE MODELS, ANIMAL; DNA; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENETIC SCREENING; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MICE; MICROSATELLITE REPEATS; MULTIGENE FAMILY; NEURAL TUBE DEFECTS; SPINAL DYSRAPHISM;

EID: 0036644303     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajmg.10435     Document Type: Article

References (10)

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2. Analysis of the developmental effects of a lethal mutation in the house mouse
3. Differential expression of Hox 3.1 protein in subregions of the embryonic and adult spinal cord
4. Vacuolated lens
5. Expression of homeobox genes during mouse development: A review
6. Promoter haplotype combinations of the platelet-derived growth factor a-receptor gene predispose to human neural tube defects
7. Biology of disease: Homeobox genes and congenital malformations
8. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci
9. Evidence for multi-site closure of the neural tube in humans
10. d) mouse mutant carries a point mutation within the paired box of the Pax-3 gene