Comparative evaluation of five different methods for the measurement of plasma factor II levels in carriers of the 20210A prothrombin variant

Blood Coagulation and Fibrinolysis

Volumn 13, Issue 5, 2002, Pages 465-470

  Delahousse, B ^a   Gilbert, M ^a   Nicham, F ^a   Thirion, C ^a   Giraudeau, B ^a   Gruel, Yves ^a  

^a SERVICE DE DERMATOLOGIE   (France)

Author keywords

Plasma FII levels; Prothrombin variant

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; CHROMOGENIC SUBSTRATE; ECARIN; PROTHROMBIN;

ADULT; AGED; ARTICLE; ASSAY; BLOOD ANALYSIS; BLOOD CLOTTING; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION; FEMALE; GENETIC STRAIN; HETEROZYGOTE; HUMAN; INTERMETHOD COMPARISON; LABORATORY TEST; MALE; PLASMA FACTOR; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; THROMBOCYTE COUNT;

3' UNTRANSLATED REGIONS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AREA UNDER CURVE; BLOOD COAGULATION TESTS; CHILD; CHILD, PRESCHOOL; CHROMOGENIC COMPOUNDS; ELAPID VENOMS; ENDOPEPTIDASES; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FACTOR VII; FACTOR X; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROTHROMBIN; ROC CURVE; SENSITIVITY AND SPECIFICITY; SERINE ENDOPEPTIDASES; THROMBOPHILIA;

EID: 0036630829     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-200207000-00013     Document Type: Article

References (8)

1. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
2. Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis
3. Prothrombin antigen levels in symptomatic and asymptomatic carriers of the 20210A prothrombin variant
4. Prothrombin activity and concentration in healthy subjects with and without the prothrombin G20210A mutation
5. A simple salting out procedure for extracting DNA from nucleated cells
6. Multiplex PCR-mediated site directed mutagenesis for one-step determination of factor V Leiden and G20210A transition of the prothrombin gene
7. Screening for prothrombin gene mutation G20210A utilizing clotting assays of FII/FX expressed as a ratio: A more cost effective method and easily adaptable to the clinical laboratory
8. Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach