The frequent Marburg I polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP)

Blood Coagulation and Fibrinolysis

Volumn 13, Issue 5, 2002, Pages 433-441

  Roemisch, Juergen ^a   Feussner, A ^a   Nerlich, C ^a   Stoehr, H A ^a   Weimer, T ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Contribution to fibrinolysis; Factor Seven Activating Protease; FSAP Marburg I mutation; Plasma hyaluronan binding protein; Polymorphism

Indexed keywords

AMINO ACID; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR VII ACTIVATING PROTEASE; DEXTRAN SULFATE; ENZYME PRECURSOR; GENOMIC DNA; NUCLEOTIDE; PROTEINASE; PROUROKINASE; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOT LYSIS; BLOOD CLOTTING; BLOOD CLOTTING TIME; BLOOD DONOR; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; FIBRINOLYSIS; GENE MUTATION; GENETIC ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTANT; PLASMA; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; THROMBOELASTOGRAPHY; WILD TYPE;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CHROMOSOMES, HUMAN, PAIR 20; CODON; DEXTRAN SULFATE; ENZYME ACTIVATION; FACTOR VII; FIBRINOLYSIS; HEPARIN; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; THROMBELASTOGRAPHY; THROMBOPHILIA; URINARY PLASMINOGEN ACTIVATOR;

EID: 0036630813     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-200207000-00008     Document Type: Article

References (9)

1. Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: It has three EGF, a kringle and a serine-protease domain, similar to hepatocyte growth factor
2. Isolation and characterization of the plasma hyaluronan-binding protein (PHBP) gene (HABP2)
3. Detection of a novel plasma serine protease during purification of vitamin K-dependent coagulation factors
4. FVII- and single-chain plasminogen activator activating protease (FSAP): Activation and autoactivation of the proenzyme
5. A protease isolated from human plasma activating factor VII independent of tissue factor
6. ProPHBP, the zymogen of a plasma hyaluronan binding serine protease, is activated by an intermolecular autocatalytic mechanism
7. The FVII activating protease cleaves single-chain plasminogen activators
8. Quantitation of the factor VII- and single-chain plasminogen activator-activating protease in plasmas of healthy subjects
9. The contribution of FVII activating protease to coagulation and fibrinolysis