On the parametrization of the toxicity of organic chemicals to tetrahymena pyriformis. The problem of establishing a uniform activity

Journal of Chemical Information and Computer Sciences

Volumn 42, Issue 4, 2002, Pages 956-961

  Mekapati, Suresh Babu ^a   Hansch, Corwin ^a  

^a POMONA COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS (QSAR);

BIOCHEMISTRY; GROWTH KINETICS; QUANTUM THEORY; TOXICITY;

ORGANIC CHEMICALS;

PHENOL DERIVATIVE;

ANIMAL; ARTICLE; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECT; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TETRAHYMENA PYRIFORMIS;

ANIMALS; COMPUTER SIMULATION; PHENOLS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYMENA PYRIFORMIS;

EID: 0036628562     PISSN: 00952338     EISSN: None     Source Type: Journal    
DOI: 10.1021/ci010250e     Document Type: Article

References (7)

1. Cronin, M.T.; Schultz, T.W. Development of Quantitative Structure-Activity Relationships for the Toxicity of Aromatic Compounds to Tetrahymena pyriformis: Comparative Assessment of the Methodologies. Chem. Res. Toxicol. 2001, 14, 1284-1295.
2. Selassie, C.D.; Shusterman, A.J.; Kapur, S.; Verma, R.P.; Zhang, L.; Hansch, C. On the Toxicology of Phenols to fast growing cells. A QSAR model for a radical-based toxicity. J. Chem. Soc., Perkin Trans. 2 1999, 2729-2733.
3. Garg, R.; Kapur, S.; Hansch, C. Radical Toxicity of Phenols; A Reference point for obtaining perspective in the formulation of QSAR. Med. Res. Rev. 2001, 21, 7382.
4. Garg, R., Kapur, A.; Hansch, C. Comparative QSAR: On the toxicology of the phenolic OH moiety. Crit. Rev. Toxicol. 2000, 31, 223-245.
5. Hansch, C.; Gao, H. Comparative QSAR: Radical reactions of benzene derivatives in Chemistry and Biology. Chem. Rev. 1997, 97, 2995-3059.
6. Hansch, C.; Gao, H.; Hoekman, D. A Generalised Approach to Comparative QSAR in Comparative QSAR; Devillers, J., Ed.; Taylor and Francis: 1998.
7. Kurita, Y.; Takayama, C. An Analytical Method to Determine Reference Orbitals for Localized Frontier Orbitals (LFOs) and its Application to the Correlation Analysis Between LFO Energies and Acidities of Conjugate Cations of Heterocyclic Bases and Monosubstituted Benzoic Acids. J. Am. Chem. Soc. 1997, 101, 5593-5595.