Effect of potassium-channel openers on the release of endothelium-derived hyperpolarizing factor in porcine coronary arteries stored in cold hyperkalemic solution

Journal of Extra-Corporeal Technology

Volumn 34, Issue 2, 2002, Pages 125-129

  Long, Cun ^a   Li, WenTao ^a   Lin, Dao Ming ^a   Yang, Jiu Guang ^a  

^a FUWAI HOSPITAL   (China)

Author keywords

Cardioplegia; Coronary vascular tension; Hyperkalemia; Hypothermia; Normothermia; Potassium channel opener

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CALCIMYCIN; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; NICORANDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT;

ANIMAL TISSUE; CARDIOPLEGIA; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY ARTERY; HEART MUSCLE; HEART PRESERVATION; HEART PROTECTION; HYPERKALEMIA; HYPERPOLARIZATION; HYPOTHERMIA; INCUBATION TIME; NONHUMAN; OPEN HEART SURGERY; PROTEIN SECRETION; SWINE;

EID: 0036625902     PISSN: 00221058     EISSN: 29698960     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (17)

1. Saldanha C, Hearse DJ. Coronary vascular responsiveness to 5-hydro-oxytryptamine before and after infusion of hyperkalemic crystalloid cardioplegic solution in the rat heart: Possible evidence of endothelial damage. J Thorac Cardiovasc Surg. 1989;98:783-7.
2. Evora PRB, Pearson PJ, Schaff HV. Crystalloid cardioplegia and hypothermia do not impair endothelium-dependent relaxation or damage vascular smooth musle of epicardial coronary arteries. J Thorac Cardiovasc Surg. 1992;104:1365-74.
3. He GW, Yang CQ, Wilson GJ, et al. Tolerance of coronary endothelium and smooth muscle to hyperkalemia. Ann Thorac Surg. 1994;57:682-8.
4. He GW, Yang CQ, Wilson GJ, et al. Effect of neonatal endothelium and smooth muscle to hyperkalemic cardioplegic solutions. J Hear Lung Transplant. 1995;14:92-101.
5. Nilsson FN, Miller VM, Vanhoutte PM, et al. Methods of cardiac preservation after the function of the endothelium in porcine coronary arteries. J Thorac Cardiovasc Surg. 1991;102:923-30.
6. He GW, Yang CQ, Graier WF, et al. Hyperkalemia alters EDHF-mediated hyperpolarization and relaxation in coronary arteries. Am J Physiol. 1996;271:H760-7.
7. He GW, Yang CQ. Hyperkalemia alters endothelium-dependent relaxation through non-nitric oxide and noncyclo-oxygenase pathway: A mechanism for coronary dysfunction due to cardioplegia. Ann Thorac Surg. 1996;61:1394-99.
8. He GW, Yang CQ. Impaired endothelium-derived hyperpolarizing factor-mediated relaxation in coronary arteries by cold storage with University of Wisconsin solution. J Thorac Cardiovasc Surg. 1998;116:122-30.
9. Hecker M, Bara AT, Bauerschs J, et al. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J Physiol (Lond). 1994;481:407-14.
10. Campbell WB, Gebremedhin D, Pratt PF, et al. Identification of epoxyeicosatrienoic acid as endothelium-derived hyperpolarizing factors. Circ Res. 1996;78:415-23.
11. Holzmann S, Kukovetz WR, Windischhofer W, et al. Pharmacologic differentiation between endothelium-dependent relaxations sensitive and resistant to nitro-L-arginine in coronary arteries. J Cardiovasc Pharmacol. 1994;23:747-56.
12. 2+-activated channels in porcine coronary artery smooth muscle cells. J Cardiovasc Pharmacol. 1998;32:642-9.
13. Lawton JS, Hsia PW, McClain LC, et al. Myocardial oxygen consumption in the rabbit heart after ischemia: Hyperpolarized arrest with pinacidil versus depolarized hyperkalemic arrest. Circulation. 1997;96(9 Suppl):II-247-52.
14. Grover GJ, Sleph PG, Parham CS. Nicorandil improves postschemic contractile function independently of direct myocardial effects. J Cardiovasc Pharmacol. 1990;15:698-705.
15. Cohen RA, Vanhoutte PM. Endothelium-dependent hyperpolarization: Beyond nitric oxide and cyclic GMP. Circulation. 1995;92:3337-49.
16. Pear JM, Laks H, Drinkwater DC, et al. Loss of endothelium-dependent vasodilatation and nitric oxide release after myocardial protection with University of Wisconsin solution. J Thorac Cardiovasc Surg. 1994;107:257-64.
17. Mankad PS, Slavik Z, Yacoub M, et al. Endothelial dysfunction caused by University of Wisconsin preservation solution in the rat heart: The importance of temperature. J Thorac Cardiovasc Surg. 1992;104:1618-24.