Oral contraceptive efficacy and antibiotic interaction: A myth debunked

Journal of the American Academy of Dermatology

Volumn 46, Issue 6, 2002, Pages 917-923

  Archer, Johanna S M ^a   Archer, David F ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; CIPROFLOXACIN; CLARITHROMYCIN; DESOGESTREL; DOXYCYCLINE; ETHINYLESTRADIOL; ETYNODIOL DIACETATE; GESTAGEN; GESTODENE; LEVONORGESTREL; METRONIDAZOLE; NORETHISTERONE; NORGESTIMATE; OFLOXACIN; ORAL CONTRACEPTIVE AGENT; RIFAMPICIN; ROXITHROMYCIN; TEMAFLOXACIN; TETRACYCLINE;

ANTIBIOTIC THERAPY; DRUG BLOOD LEVEL; DRUG EFFICACY; EMBASE; FEMALE; HIGH RISK POPULATION; HUMAN; MEDLINE; PHARMACOKINETICS; PREGNANCY; PRIORITY JOURNAL; REVIEW;

EID: 0036622004     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1067/mjd.2002.120448     Document Type: Article

References (46)

1. American College of Obstetricians and Gynecologists. The use of hormonal contraception in women with coexisting medical conditions. ACOG Practice Bulletin 2000;18:1-13.
2. Thiboutot D, Archer DF, Lemay A, Washenik K, Roberts J, Harrison DD. A randomized, controlled trial of 20 μg ethinyl estradiol/100 μg levonorgestrel for acne treatment. Fertil Steril 2001; 76:461-8.
3. Lucky AW, Henderson TA, Olson WH, Robisch DM, Lebwohl M, Swinyer LJ. Effectiveness of norgestimate and ethinyl estradiol in treating moderate acne vulgaris. J Am Acad Dermatol 1997; 37:746-54.
4. Redmond GP, Olson WH, Lippman JS, Kafrissen ME, Jones TM, Jorizzo JL. Norgestimate and ethinyl estradiol in the treatment of acne vulgaris: a randomized, placebo-controlled trial. Obstet Gynecol 1997;89:615-22.
5. Shenfield GM. Oral contraceptives. Are drug interactions of clinical significance? Drug Saf 1993;9:21-37.
6. Orme ML'E, Back DJ. Factors affecting the enterohepatic circulation of oral contraceptive steroids. Am J Obstet Gynecol 1990; 163:2146-52.
7. Hanker JP. Gastrointestinal disease and oral contraception. Am J Obstet Gynecol 1990;163:2204-7.
8. Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orme ML'E, Rowe PH, et al. An investigation of the pharmacokinetics of ethynyl estradiol in women using radioimmunoassay. Contraception 1979;20:263-73.
9. Back DJ, Orme ML'E. Drug interactions. In: Goldzieher JW, Fotherby K, editors. Pharmacology of the contraceptive steroids. New York: Raven Press; 1994. p. 407-25.
10. Orme ML'E, Back DJ. Interactions between oral contraceptive steroids and broad-spectrum antibiotics. Clin Exp Dermatol 1986;11:327-31.
11. Kuhl H. Pharmacokinetics of oestrogens and progestogens. Maturitas 1990;12:171-97.
12. Back DJ, Bates M, Burke MW, Breckenridge AM, Crawford FE, MacIver M, et al. Plasma Xa inhibitory activities and plasma concentrations of norgestrel and ethinyloestradiol in women on oral contraceptive steroids. Br J Clin Pharmacol 1979;8:505-6.
13. Shenfield GM, Griffin JM. Clinical pharmacokinetics of contraceptive steroids. An update. Clin Pharmacokinet 1991;20:15-37.
14. Murphy AA, Zacur HA, Charache P, Burkman RT. The effect of tetracycline on levels of oral contraceptives. Am J Obstet Gynecol 1991;164:28-33.
15. Back DJ, Breckenridge AM, Crawford F, MacIver M, Orme ML'E, Park BK, et al. The effect of rifampicin on norethisterone pharmacokinetics. Eur J Clin Pharmacol 1979;15:193-7.
16. Back DJ, Breckenridge AM, Crawford FE, Hall JM, MacIver M, Orme ML'E, et al. The effect of rifampicin on the pharmacokinetics of ethynylestradiol in women. Contraception 1980;21:135-43.
17. Barditch-Crovo P, Trapnell CB, Ette E, Zacur HA, Coresh J, Rocco LE, et al. The effects of rifampin and rifabutin on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive. Clin Pharmacol Ther 1999;65:428-38.
18. LeBel M, Masson E, Guilbert E, Colborn D, Paquet F, Allard S, et al. Effects of rifabutin and rifampicin on the pharmacokinetics of ethinylestradiol and norethindrone. J Clin Pharmacol 1998;38: 1042-50.
19. Adlercreutz H, Martin F, Lehtinen T, Tikkanen MJ, Pulkkinen MO. Effect of ampicillin administration on plasma conjugated and unconjugated estrogen and progesterone levels in pregnancy. Am J Obstet Gynecol 1977;128:266-71.
20. Dada OA, Martins OO. Drug effects on the intestinal absorption of estrogens. J Steroid Biochem 1983;19:821-5.
21. Back DJ, Breckenridge AM, MacIver M, Orme ML'E, Rowe PH, Staiger C, et al. The effects of ampicillin oral contraceptive steroids in women. Br J Clin Pharmacol 1982;14:43-8.
22. Friedman CI, Huneke AL, Kim MH, Powell J. The effect of ampicillin on oral contraceptive effectiveness. Obstet Gynecol 1980; 55:33-7.
23. Joshi JV, Joshi UM, Sankholi GM, Krishna U, Mandlekar A, Chowdhury V, et al. A study of interaction of low-dose combination oral contraceptive with ampicillin and metronidazole. Contraception 1980;22:643-52.
24. Maggiolo F, Puricelli G, Dottorini M, Caprioli S, Bianchi W, Suter F. The effect of ciprofloxacin on oral contraceptive steroid treatments. Drugs Exp Clin Res 1991;17:451-4.
25. Scholten PC, Droppert RM, Zwinkels MG, Moesker HL, Nauta JJ, Hoepelman IM. No interaction between ciprofloxacin and an oral contraceptive. Antimicrob Agents Chemother 1998;42:3266-8.
26. Back DJ, Tjia C, Martin C, Miller E, Salmon P. The interaction between clarithromycin and combined oral contraceptive steroids. J Pharm Med 1991;2:81-7.
27. Neely JL, Abate M, Swinker M, D'Angio R. The effect of doxycycline on serum levels of ethinyl estradiol, norethindrone, and endogenous progesterone. Obstet Gynecol 1991;77:416-20.
28. Csemiczky G, Alvendal C, Landgren BM. Risk for ovulation in women taking a low-dose oral contraceptive (Microgynon) when receiving antibacterial treatment with a fluoroquinolone (ofloxacin). Adv Contracept 1996;12:101-9.
29. Meyer B, Muller F, Wessels P, Maree J. A model to detect interactions between roxithromycin and oral contraceptives. Clin Pharmacol Ther 1990;47:671-4.
30. Back DJ, Tjia J, Martin C, Millar E, Mant T, Morrison P, et al. The lack of interaction between temafloxacin and combined oral contraceptive steroids. Contraception 1991;43:317-23.
31. Grimmer SF, Allen WL, Back DJ, Breckenridge AM, Orme ML'E, Tjia J. The effect of cotrimoxazole on oral contraceptive steroids in women. Contraception 983;28:53-9.
32. Leigh DA, Reeves DS, Simmons K, Thomas AL, Wilkinson PJ. Talampicillin: a new derivative of ampicillin. BMJ 1976;2:378-80.
33. Wermeling DP, Chandler MHH, Sides GD, Collins D, Muse KN. Dirithromycin increases ethinyl estradiol clearance without allowing ovulation. Obstet Gynecol 1995;85:78-84.
34. Sparrow MJ. Pill method failures. N Z Med J 1987;100:102-5.
35. Silber TJ. Apparent oral contraceptive failure associated with antibiotic administration. J Adolesc Health Care 1983;4:287-9.
36. London BM, Lookingbill DP. Frequency of pregnancy in acne patients taking oral antibiotics and oral contraceptives [letter]. Arch Dermatol 1994;130:392-3.
37. DeSano EA Jr, Hurley SC. Possible interactions of antihistamines and antibiotics with oral contraceptive effectiveness. Fertil Steril 1982;37:853-4.
38. Back DJ, Grimmer SF, Orme ML'E, Proudlove C, Mann RD, Breckenridge AM. Evaluation of Committee on Safety of Medicines yellow card reports on oral contraceptive-drug interactions with anticonvulsants and antibiotics. Br J Clin Pharmacol 1988;25:527-32.
39. Fraser IS, Jansen RPS. Why do inadvertent pregnancies occur in oral contraceptive users? Effectiveness of oral contraceptive regimens and interfering factors. Contraception 1983;27:531-51.
40. Rosenberg MJ, Waugh MS, Stevens CM. Smoking and cycle control among oral contraceptive users. Am J Obstet Gynecol 1996; 174:628-32.
41. Szoka PR, Edgren RA. Drug interactions with oral contraceptives: compilation and analysis of an adverse experience report database. Fertil Steril 1988;49(Suppl):31S-8S.
42. Helms SE, Bredle DL, Zajic J, Jarjoura D, Brodell RT, Krishnarao I. Oral contraceptive failure rates and oral antibiotics. J Am Acad Dermatol 1997;36:705-10.
43. Stockley I. Interactions with oral contraceptives. Pharm J 1976; 140-3.
44. Back DJ, Breckenridge AM, Challiner M, Crawford FE, Orme ML'E, Rowe PH, et al. The effect of antibiotics on the enterohepatic circulation of ethinylestradiol and norethisterone in the rat. J Steroid Biochem 1978;9:527-31.
45. Fotherby K. Interactions with oral contraceptives. Am J Obstet Gynecol 1990;163:2153-9.
46. LaCasa C. California court denies wrongful birth claim. J Law Med Ethics 1996;24:273-4.