Different regulatory elements within the MyoD promoter control its expression in the brain and inhibit its functional consequences in neurogenesis

Tissue and Cell

Volumn 34, Issue 3, 2002, Pages 164-169

  Kablar, Boris ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Brain; Embryo; Gene regulation; Mouse; MyoD

Indexed keywords

MYOD PROTEIN; RNA; BETA GALACTOSIDASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MEDIAL LONGITUDINAL FASCICULUS; MEDULLA OBLONGATA; MOUSE; MOUSE MUTANT; MUSCLE DEVELOPMENT; MYOTOME; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; PONS; REPORTER GENE; SKELETAL MUSCLE; SPINAL CORD; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; BIOSYNTHESIS; EMBRYO; GENETICS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; METABOLISM; PRENATAL DEVELOPMENT; PROMOTER REGION;

MUS MUSCULUS;

ANIMALS; BETA-GALACTOSIDASE; BRAIN; EMBRYO; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; MYOD PROTEIN; NEURONS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SPINAL CORD;

EID: 0036619341     PISSN: 00408166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-8166(02)00027-7     Document Type: Article

References (24)

1. The regulation of MyoD gene expression: Conserved elements mediate expression in embryonic axial muscle
2. Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro
3. Targeted inactivation of the muscle regulatory gene myf-5 results in abnormal rib development and perinatal death
4. MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes
5. Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons
6. Embryonic activation of the MyoD gene is regulated by a highly conserved distal control element
7. Development in the absence of skeletal muscle results in the sequential ablation of motor neurons from the spinal cord to the brain
8. Skeletal muscle development in the mouse embryo
9. MyoD and Myf-5 differentially regulate the development of limb versus trunk skeletal muscle
10. MyoD and Myf-5 define the specification of musculature of distinct embryonic origin
11. Myogenic determination occurs independently in somites and limb buds
12. Simplified mammalian DNA isolation procedure
13. Overexpression of XmyoD and Xmyf5 in Xenopus embryos induces the formation of enlarged myotomes through recruitment of cells of nonsomitic lineage
14. Genetic control of cortical regionalization and connectivity
15. Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development
16. MyoD or Myf-5 is required for the formation of skeletal muscle
17. Expression of two myogenic regulatory factors, myogenin and MyoD1, during mouse embryogenesis
18. Lineage restriction of the myogenic conversion factor myf-5 in the brain
19. Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD
20. A novel myoblast enhancer element mediates MyoD transcription
21. The myoD gene family: Nodal point during specification of the muscle cell lineage