Synaptically Targeted Narp Plays an Essential Role in the Aggregation of AMPA Receptors at Excitatory Synapses in Cultured Spinal Neurons

Journal of Neuroscience

Volumn 22, Issue 11, 2002, Pages 4487-4498

  O'Brien, Richard ^a,b   Xu, Desheng ^a   Mi, Ruifa ^a   Tang, Xiaopei ^a   Hopf, Carsten ^a   Worley, Paul ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Excitatory synapses; Glutamate receptors; Narp; Pentraxin; Spinal neurons; Synaptogenesis

Indexed keywords

AMPA RECEPTOR; GEPHYRIN; GLUTAMATE RECEPTOR; INHIBITOR PROTEIN; MUTANT PROTEIN; PENTRAXIN; PROTEIN NARP; UNCLASSIFIED DRUG; C REACTIVE PROTEIN; CARRIER PROTEIN; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2; MEMBRANE PROTEIN; NERVE PROTEIN; NEURONAL PENTRAXIN; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CAPPING PHENOMENON; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENDRITE; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NERVE CELL STIMULATION; NERVE FIBER; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; SPINAL CORD NERVE CELL; STAINING; SYNAPSE VESICLE; SYNAPTOGENESIS; WILD TYPE; ANIMAL; CELL CULTURE; CYTOLOGY; DOMINANT GENE; GENE EXPRESSION; GENETICS; IMMUNOBLOTTING; KIDNEY; MACROMOLECULE; METABOLISM; NERVE CELL; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS; SPINAL CORD; SYNAPSE;

ANIMALS; C-REACTIVE PROTEIN; CARRIER PROTEINS; CELLS, CULTURED; DENDRITES; GENE EXPRESSION; GENES, DOMINANT; HUMANS; IMMUNOBLOTTING; KIDNEY; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; NEURONS; RATS; RECEPTOR AGGREGATION; RECEPTORS, AMPA; SPINAL CORD; SYNAPSES; SYNAPTOPHYSIN; TRANSFECTION;

EID: 0036618317     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-11-04487.2002     Document Type: Article

References (27)

1. Beck K, Brodsky B (1998) Supercoiled protein motifs: the collagen triple-helix and the alpha-helical coiled coil. J Struct Biol 122:17-29.
2. Burack MA, Silverman M, Banker G (2000) The role of selective transport in neuronal protein sorting. Neuron 26:465-472.
3. Cantallops I, Cline HT (2000) Synapse formation: if it looks like a duck and quacks like a duck.... Curr Biol 10:R620-623.
4. Cantallops I, Haas K, Cline HT (2000) Postsynaptic CPG15 promotes synaptic maturation and presynaptic axon arbor elaboration in vivo. Nat Neurosci 3:1004-1011.
5. Dodds DC, Omeis IA, Cushman SJ, Helms JA, Perin MS (1997) Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. J Biol Chem 272:21488-21494.
6. Dong H, O'Brien RJ, Fung ET, Lanahan AA, Worley PF, Huganir RL (1997) GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature 386:279-284.
7. Dong H, Zhang P, Song I, Petralia RS, Liao D, Huganir RL (1999) Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2. J Neurosci 19:6930-6941.
8. Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP (1994) Structure of pentameric human serum amyloid P component. Nature 367:338-345.
9. Garner CC, Nash J, Huganir RL (2000) PDZ domains in synapse assembly and signaling. Trends Cell Biol 10:274-280.
10. Goodman AR, Cardozo T, Abagyan R, Altmeyer A, Wisniewski HG, Vilcek J (1996) Long pentraxins: an emerging group of proteins with diverse functions. Cytokine Growth Factor Rev 7:191-202.
11. Guzowski JF, McNaughton BL, Barnes CA, Worley PF (1999) Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles. Nat Neurosci 2:1120-1124.
12. Kim JH, Huganir RL (1999) Organization and regulation of proteins at synapses. Curr Opin Cell Biol 11:248-254.
13. Kim JH, Liao D, Lau LF, Huganir RL (1998) SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 20:683-691.
14. Mammen AL, Huganir RL, O'Brien RJ (1997) Redistribution and stabilization of cell surface glutamate receptors during synapse formation. J Neurosci 17:7351-7358.
15. Naisbitt S, Kim E, Tu JC, Xiao B, Sala C, Valtschanoff J, Weinberg RJ, Worley PF, Sheng M (1999) Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron 23:569-582.
16. O'Brien RJ, Mammen AL, Blackshaw S, Ehlers MD, Rothstein JD, Huganir RL (1997) The development of excitatory synapses in cultured spinal neurons. J Neurosci 17:7339-7350.
17. O'Brien RJ, Kamboj S, Ehlers MD, Rosen KR, Fischbach GD, Huganir RL (1998) Activity-dependent modulation of synaptic AMPA receptor accumulation. Neuron 21:1067-1078.
18. O'Brien RJ, Xu D, Petralia RS, Steward O, Huganir RL, Worley P (1999) Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron 23:309-323.
19. Reti IM, Baraban JM (2000) Sustained increase in Narp protein expression following repeated electroconvulsive seizure. Neuropsychopharmacology 23:439-443.
20. Rudenko G, Nguyen T, Chelliah Y, Sudhof TC, Deisenhofer JC (1999) The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing. Cell 99:93-101.
21. Scheiffele P, Fan J, Choih J, Fetter R, Serafini T (2000) Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 101:657-669.
22. Schlimgen AK, Helms JA, Vogel H, Perin MS (1995) Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system. Neuron 14:519-526.
23. Song I, Kamboj S, Xia J, Dong H, Liao D, Huganir RL (1998) Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors. Neuron 21:267-270.
24. Tisi D, Talts JF, Timpl R, Hohenester E (2000) Structure of the C-terminal laminin G-like domain pair of the laminin alpha2 chain harbouring binding sites for alpha-dystroglycan and heparin. EMBO J 19:1432-1440.
25. Tsui CC, Copeland NG, Gilbert DJ, Jenkins NA, Barnes C, Worley PF (1996) Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity. J Neurosci 16:2463-2478.
26. Turrigiano G (2000) AMPA receptors unbound: membrane cycling and synaptic plasticity. Neuron 26:5-8.
27. Xia J, Zhang X, Staudinger J, Huganir RL (1999) Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron 22:179-187.