Histological and elemental changes in the rat brain after local irradiation with carbon ion beams

Journal of Radiation Research

Volumn 43, Issue 2, 2002, Pages 143-152

  Takahashi, Sentaro ^a   Sun, Xue Zhi ^a   Kubota, Yoshihisa ^a   Takai, Nobuhiko ^a   Nojima, Kumie ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Carbon beam; Histology; Ionic level; Local irradiation; Rat

Indexed keywords

CARBON; CELL DEATH; ION BEAMS; IRRADIATION; RATS; TISSUE;

CARBON BEAMS; CARBON ION BEAMS; CARBON PARTICLE; IONIC LEVEL; LOCAL IRRADIATION; NEURONAL CELL; POSTIRRADIATION; RATS BRAIN; SPREAD OUT BRAGG PEAKS; TISSUE DAMAGE;

BRAIN;

CARBON; ION;

ANIMAL; ARTICLE; BRAIN; MALE; METABOLISM; PATHOLOGY; RADIATION EXPOSURE; RADIATION INJURY; RAT; SPRAGUE DAWLEY RAT; X RAY;

ANIMALS; BRAIN; CARBON; IONS; MALE; RADIATION INJURIES; RATS; RATS, SPRAGUE-DAWLEY; X-RAYS;

EID: 0036617633     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.43.143     Document Type: Article

References (28)

1. O'Connor, M. M. and Mayberg, M. R. (2000) Effects of radiation on cerebral vasculature: a review. Neurosurgery. 46: 138-149.
2. Hopewell, J. W. and van der Kogel, A. J. (1999) Pathophysiological mechanisms leading to the development of late radiation-induced damage to the central nervous system. Front Radiat. Ther. Oncol. 33: 265-275.
3. Schultheiss, T. E., Kun, L. E., Ang, K. K. and Stephens, L. C. (1995) Radiation response of the central nervous system. Int. J. Radiat. Oncol. Biol. Phys. 31: 1093-1112.
4. Lampert, P., Tom, M. I. and Rider, W. D. (1959) Disseminated demyelination of the brain following Co-60 (gamma) radiation. Am. Med. Assoc. Arch. Pathol. 68: 322-330.
5. Chiang, C-S., McBride, W. H. and Withers, H. R. (1993) Myelin-associated changes in mouse brain following irradiation. Radiotherap. Oncol. 27: 229-236.
6. Calvo, W., Hopewell, J. W., Reinhold, M. S. and Yeung, T. K. (1988) Time-and dose-related changes in the white matter of the rat brain after single of doses of X-rays. Br. J. Radiol. 61: 1043-1052.
7. Reyners, H., Gianfelici de Reyners, E. and Maisin, J. R. (1986) Early cell regeneration processes after split-dose X-irradiation of the cerebral cortex of the rat. Br. J. Cancer. 53 (Suppl. VII): 218-220.
8. Kamiryo, T., Kassell, N. F., Thai, Q-A, Lopes, M. B. S., Lee, K. S. and Steiner, L. (1996). Histological changes in the normal rat brain after gamma irradiation. Acta Neurochir. 138: 451-459.
9. Yoshii, Y. and Phillips, T. L. (1982) Late vascular effects of whole brain X-irradiation in the mouse. Acta. Neurochir. 64: 87-102.
10. Hopewell, J. W. and Wtight, E. A. (1970) The nature of latent cerebral irradiation damage and its modification by hypertension. Br. J. Radiol. 43: 161-167.
11. Chiang, C-S., McBride, W. H. and Withers, H. R. (1993) Radiation-induced astrocytic and microglial responses in mouse brain. Radiotherap. Oncol. 29: 60-68.
12. Kanai, T., Endo, M., Minohara, S., Miyahara, N., Koyama-ito, H., Tomura, H., Matsufuji, N., Futami, Y., Fukumura, A., Hiraoka, T., Furusawa, Y., Ando, K., Suzuki, M., Soga, F. and Kawachi, K. (1999) Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 44: 201-210.
13. Kanai, T., Furusawa, Y., Fukutsu, K., Itsukaichi, H., Eguchi-Kasai, K. and Ohara, H. (1997) Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy. Radiat. Res. 147: 78-85.
14. Mickley, G. A., Ferguson, J. L., Nemeth, T. J., Mulvihill, M. A. and Alderks, C. E. (1989) Spontaneous perseverative turning in rats with radiation-induced hippocampal damage. Behav. Neurosci. 103: 722-730.
15. Hatashita, S. and Hoff, J. T. (1986) Role of a hydrostatic pressure gradient in the formation of early ischemic brain edema. J. Cereb. Blood. Flow. Metab. 6: 546-552.
16. Hatashita, S., Hoff, J. T. and Salamat, S. M. (1988) Ischemic brain edema and the osmotic gradient between blood and brain. J. Cereb. Blood. Flow. Metab. 8: 552-559.
17. Hatashita, S., Tajima, A., Ueno, H., Ishimaru, S., Sato, H. and Takahashi, S. (1997) Blood volume and flow velocity through parenchymal microvessels in ischemic brain edema of rats. Acta Neurochir. 70: 23-26.
18. Takahashi, S., Hatashita, S., Taba, Y., Sun, X-Z., Kubota, Y. and Yoshida, S. (2000) Determination of the spatial distribution of major elements in the rat brain with X-ray fluorescence analysis. J. Neurosci. Met. 100: 53-62.
19. Hirao, Y., Ogawa, H., Yamada, S., Sato, Y., Yamada, T., Sato, K., Itano, A., Kanazawa, M., Noda, K., Kawachi, K., Endo, M., Kanai, T., Kohno, T., Sudou, M., Minohara, S., Kitagawa, A., Soga, F., Takada, E., Watanabe, S., Endo, K., Kumada, M. and Matsumoto, S. (1992) Heavy ion synchrotron for medical use-HIMAC project aat NIRS-JAPAN. Nucl. Phys. A. 538: 541c-550c.
20. Berg, N. O. and Lindgren, M. (1958) Time-dose relationship and morphology of delayed radiation lesions of the brain in rabbits. Acta Radiological Suppl. 167: 1-118.
21. Hopewell, J. W. and Wright, E. A. (1970) The nature of latent cerebral irradiation damage and its modification by hypertension. Br. J. Radiol. 43: 161-167.
22. Kristian, T. and Siesjo, B. K. (1997) Changes in ionic flues during cerebral ischaemia. Int. Rev. Neurobiol. 40: 27-45.
23. Young, W., DeCrescito, V., Flamm, E. S., Hadani, M., Rappaport, H. and Cornu, P. (1986) Tissue Na, K, and Ca changes in regional cerebral ischemia: their measurement and interpretation. Cent. Nerv. Syst. Trauma. 3: 215-234.
24. Young, W. and Koreh, I. (1986) Potassium and calcium changes in injured spinal cords. Brain Res. 365: 42-53.
25. Takahashi, H., Tanaka, S. and Sano, K. (1981) Changes in extracellular potassium concentration in cortex and brain stem during the acute phase of experimental closed head injury. J. Neurosurg. 55: 708-717.
26. Hansen, A. J.(1985) Effects of anoxia on ion distribution in the brain. Physiol. Rev. 65: 101-148.
27. Lyubimova, N. V., Leitman, K., Plotnikova, E. D. and Eidus, L. K. (1991) Endothelial cell population dynamics in rat brain after local irradiation. Brit. J. Radiol. 64: 934-940.
28. Rubin, P., Gash, D. M., Hansen, J. R., Nelson, D. F. and Williams, J. P. (1994) Disruption of the blood-brain barrier as the primary effect of CNS irradiation. Radiotherapy Oncol. 31: 51-60.