The anti-apoptotic property of NS-398 at high dose can be mediated in part through NF-kappaB activation, hsp70 induction and a decrease in caspase-3 activity in human osteosarcoma cells.

International journal of oncology

Volumn 20, Issue 6, 2002, Pages 1255-1262

  Moalic Juge, Sandra ^a   Liagre, Bertrand ^a   Duval, Raphaël ^a   Corbiere, Cecile ^a   Bianchi, Arnaud ^a   Bordji, Karim ^a   Bosgiraud, Claudine ^a   Beneytout, Jean Louis ^a  

^a UNIVERSITY OF LIMOGES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASP3 PROTEIN, HUMAN; CASPASE; CASPASE 3; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE; NITROBENZENE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; SULFONAMIDE; TRANSCRIPTION FACTOR AP 1;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; BONE TUMOR; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; OSTEOSARCOMA; PATHOLOGY; PHYSIOLOGY; TUMOR SUPPRESSOR GENE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; BONE NEOPLASMS; CASPASE 3; CASPASES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; CYCLOOXYGENASE INHIBITORS; GENES, P53; HSP70 HEAT-SHOCK PROTEINS; HUMANS; NF-KAPPA B; NITROBENZENES; OSTEOSARCOMA; RNA, MESSENGER; SULFONAMIDES; TRANSCRIPTION FACTOR AP-1;

EID: 0036616014     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)