3-Isobutyl-1-methylxanthine (IBMX) sensitizes cardiac myocytes to anoxia

Biochemical Pharmacology

Volumn 63, Issue 11, 2002, Pages 2055-2062

  Geisbuhler, Timothy P ^a   Schwager, Tammie L ^a   Ervin, Heather D ^a  

^a A T STILL UNIVERSITY   (United States)

Author keywords

3 Isobutyl 1 methylxanthine; 8 Cyclopentyl 1,3 dipropylxanthine; Anoxia; ATP ADP ratio; Heart; Myocyte; Verapamil; Zaprinast

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL L TYPE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITOR; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG; VERAPAMIL; ZAPRINAST;

ANIMAL CELL; ANIMAL MODEL; ANOXIA; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SENSITIZATION; INCUBATION TIME; MUSCLE CELL; NONHUMAN; ONSET AGE; PREMATURITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; ANOXIA; CELL HYPOXIA; HEART; MYOCARDIUM; PHOSPHODIESTERASE INHIBITORS; RATS;

EID: 0036609019     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00901-2     Document Type: Article

References (30)

1. 2+, ATP, and compartmentation
2. Direct observation of the oxygen paradox in single rat ventricular myocytes
3. Heart myocytes as models of the cellular response to ischemia
4. ++ in single rat heart cells during anoxia and reoxygenation
5. Lactate does not enhance anoxia/reoxygenation damage in adult rat cardiac myocytes
6. Heat production during hypoxic contracture of rat myocardium
7. Bioluminescent measurement in single cardiomyocytes of sudden cytosolic ATP depletion coincident with rigor
8. Modulation of rigor and myosin ATPase activity in rat cardiomyocytes
9. Effects of calcium depletion and loading on injury during metabolic inhibition of isolated adult rat myocytes
10. Effect of anoxia on cyclic nucleotides and inositol phosphate turnover in cardiac myocytes
11. Pharmacological treatment of heart failure
12. Multiple pathway signal transduction by the cAMP-dependent protein kinase
13. Myocardial buffering capacity in ischemia preconditioned rat hearts
14. Ischemic preconditioning slows ischemic metabolism and limits myocardial infarct size
15. Mechanism of preconditioning: Ionic alterations
16. Adenine nucleotide metabolism and compartmentalization in isolated adult rat heart cells
17. Guanosine metabolism in adult rat cardiac myocytes: Ribose-enhanced GTP synthesis from extracellular guanosine
18. Zaprinast: A cGMP-selective phosphodiesterase inhibitor
19. Perforated-patch recording does not enhance effect of 3-isobutyl-1-methylxanthine on cardiac calcium current
20. Differential effects of phosphodiesterase inhibitors on accumulation of cyclic AMP in isolated ventricular cardiomyocytes
21. Hyperthyroid adult rat cardiomyocytes. I. Nucleotide content, β- and α-adrenoreceptors, and cAMP production
22. in
23. Cardiac myocyte guanosine transport and metabolism
24. Protein measurement with the Folin phenol reagent
25. Forskolin inhibition of hexose transport in cardiomyocytes
26. Cardiotonic actions of selective phosphodiesterase inhibitors in rat isolated ventricular cardiomyocytes
27. Compartmentation of guanine nucleotides in anoxic cardiac myocytes
28. Compartmentalization of pyrimidine nucleotides in anoxic cardiac myocytes