Toward RNase inhibitors: Thermodynamics of 2′-CMP/RNase-A binding in multi-ion buffer

Biochemical Pharmacology

Volumn 63, Issue 11, 2002, Pages 1937-1939

  Raffa, Robert B ^a,b   Spencer, Shawn D ^a   Schulingkamp, Robert J ^a,c  

^a TEMPLE UNIVERSITY   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

Microcalorimetry; RNase; Thermodynamics

Indexed keywords

2' CYTIDYLIC ACID; BUFFER; CYTIDINE DERIVATIVE; HYDROLASE INHIBITOR; RIBONUCLEASE A; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; ENTHALPY; ENZYME BINDING; MICROCALORIMETRY; NONHUMAN; PRIORITY JOURNAL; THERMODYNAMICS; TITRIMETRY;

ANIMALS; BINDING SITES; BUFFERS; CATTLE; CYTIDINE MONOPHOSPHATE; ENZYME INHIBITORS; METALS; RIBONUCLEASE, PANCREATIC; THERMODYNAMICS;

EID: 0036608557     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00977-2     Document Type: Article

References (9)

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5. Toward the design of RNase inhibitors: Ion effects on the thermodynamics of binding of 2′-CMP to RNase-A
6. + Konzentrationen in kultivierten Hepatozyten unter hypoxischen Bedingungen
7. Rapid measurement of binding constants and heats of binding using a new titration calorimeter
8. Molecular evolution of the ribonuclease superfamily