A new spin on protein dynamics

Trends in Biochemical Sciences

Volumn 27, Issue 6, 2002, Pages 288-295

  Columbus, Linda ^a   Hubbell, Wayne L ^a  

^a JULES STEIN EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANNEXIN XII; BACTERIORHODOPSIN; COLICIN E1; G PROTEIN COUPLED RECEPTOR; LACTOSE PERMEASE; LYSOZYME; MEMBRANE PROTEIN; NITROXIDE; RHODOPSIN; TRANSCRIPTION FACTOR GCN4; UNCLASSIFIED DRUG;

ALPHA HELIX; CARBOXY TERMINAL SEQUENCE; DYNAMICS; ELECTRON SPIN RESONANCE; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; REVIEW; SPIN LABELING;

ANIMALS; DNA-BINDING PROTEINS; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; MODELS, MOLECULAR; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RHODOPSIN; SACCHAROMYCES CEREVISIAE PROTEINS; SPIN LABELS;

EID: 0036606899     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(02)02095-9     Document Type: Review

References (58)

1. Two-state allosteric behavior in a single-domain signaling protein
2. Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function
3. Solution-state NMR investigations of triosephosphate isomerase active site loop motion: Ligand release in relation to active site loop dynamics
4. Studying excited states of proteins by NMR spectroscopy
5. Watching proteins move using site-directed spin labeling
6. Identifying conformational changes with site-directed spin labeling
7. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
8. Structure of the KcsA channel intracellular gate in the open state
9. Substrate-induced exposure of an energy-coupling motif of a membrane transporter
10. Crystal structure of a G-protein βγ dimer at 2.1 Å resolution
11. Crystal structure of rhodopsin: A G protein-coupled receptor
12. Molecular switch for signal transduction: Structural differences between active and inactive forms of protooncogenic Ras proteins
13. Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity
14. Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 2. Analysis of experimental results
15. Nuclear magnetic resonance studies of biopolymer dynamics
16. NMR probes of molecular dynamics: Overview and comparison with other techniques
17. Backbone dynamics of the human CC chemokine eotaxin: Fast motions, slow motions, and implications for receptor binding
18. Inherent flexibility in a potent inhibitor of blood coagulation, recombinant nematode anticoagulant protein c2
19. Temperature dependence of intramolecular dynamics of the basic leucine zipper of GCN4: Implications for the entropy of association with DNA
20. Motion of spin-labeled side chains in T4 lysozyme. Correlation with protein structure and dynamics
21. Crystal structures of spin labeled T4 lysozyme mutants: Implications for the interpretation of EPR spectra in terms of structure
22. Molecular motion of spin labeled side chains in α-helices: Analysis by variation of side chain structure
23. Nonlinear-least-squares analysis of slow-motion EPR spectra in one and two dimensions using a modified Levenberg-Marquardt algorithm
24. A multifrequency electron spin resonance study of T4 lysozyme dynamics
25. Structure and dynamics of a helical hairpin and loop region in annexin 12: A site-directed spin labeling study
26. Molecular motion in spin-labeled phospholipids and membranes
27. Insights into membrane insertion based on studies of colicins
28. Structure in the channel forming domain of colicin E1 bound to membranes: The 402-424 sequence
29. A mechanism for toxin insertion into membranes is suggested by the crystal structure of the channel-forming domain of colicin E1
30. Structure and dynamics of the colicin E1 channel
31. Membrane-mediated assembly of annexins studied by site-directed spin labeling
32. Relationships between protein structure and dynamics from a database of NMR-derived backbone order parameters
33. Characterizing semilocal motions in proteins by NMR relaxation studies
34. NMR evidence for slow collective motions in cyanometmyoglobin
35. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
36. Cys-scanning mutagenesis: A novel approach to structure function relationships in polytopic membrane proteins
37. Structure of bacteriorhodopsin at 1.55 Å resolution
38. Site-directed spin labeling demonstrates that transmembrane domain XII in the lactose permease of Escherichia coli is an α-helix
39. Transmembrane protein structure: Spin labeling of bacteriorhodopsin mutants
40. The lipid bilayer determines helical tilt angle and function in lactose permease of Escherichia coli
41. Engineering a metal binding site within a polytopic membrane protein, the lactose permease of Escherichia coli
42. Infrared spectroscopy study of photoreceptor membrane and purple membrane: Protein secondary structure and hydrogen-deuterium exchange
43. Molecular mechanism of vectorial proton translocation by bacteriorhodopsin
44. Light-induced binding of 48-kDa protein to photoreceptor membranes is highly enhanced by phosphorylation of rhodopsin
45. Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: A site-directed spin-labeling study
46. Mapping light-dependent structural changes in the cytoplasmic loop connecting helices C and D in rhodopsin: A site-directed spin labeling study
47. Structural features of the C-terminal domain of bovine rhodopsin: A site-directed spin-labeling study
48. Structural features and light-dependent changes in the sequence 59-75 connecting helices I and II in rhodopsin: A site-directed spin-labeling study
49. Structural features and light-dependent changes in the sequence 306-322 extending from helix VII to the palmitoylation sites in rhodopsin: A site-directed spin-labeling study
50. Dynamic properties of the Ras switch I region and its importance for binding to effectors
51. The structural basis for substrate recognition and control by protein kinases
52. Theory of slow tumbling ESR spectra for nitroxides
53. Dynamic activation of protein fluctuations: A view emerging from NMR spectroscopy
54. Electron spin resonance of TOAC labeled peptides: Folding transitions and high frequency spectroscopy
55. Site-specific incorporation of biophysical probes into proteins
56. Microsecond rotational dynamics of spin-labeled myosin regulatory light chain induced by relaxation and contraction of scallop muscle
57. Crystal structure of the annexin XII hexamer and implications for bilayer insertion