Cytotocxic and antiviral activties of Colombian medicinal plant exatracts of the Euphorbia genus

Memorias do Instituto Oswaldo Cruz

Volumn 97, Issue 4, 2002, Pages 541-546

  Betancur Galvis, L A ^a   Morales, G E ^a   Forero, J E ^a   Roldan, J ^a  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

Author keywords

Antiviral; Colombia; Ethnobotany; Euphorbiaceae; Herpes simplex virus; Medicinal plants

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; PLANT EXTRACT;

ANIMAL; ARTICLE; BIOASSAY; CELL CULTURE; CHEMISTRY; CHO CELL; COLOMBIA; COLORIMETRY; DRUG EFFECT; DRUG SCREENING; EUPHORBIA; FEMALE; HAMSTER; HELA CELL; HERPES SIMPLEX VIRUS 2; HUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIVIRAL AGENTS; CELLS, CULTURED; CHO CELLS; COLOMBIA; COLORIMETRY; CRICETINAE; DRUG SCREENING ASSAYS, ANTITUMOR; ENDPOINT DETERMINATION; EUPHORBIA; FEMALE; HELA CELLS; HERPESVIRUS 2, HUMAN; HUMANS; PLANT EXTRACTS;

EID: 0036595137     PISSN: 00740276     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0074-02762002000400017     Document Type: Article

References (29)

1. Baker JT, Borris RP, Carte B, Cordell GA, Soejarto DD, Cragg GM, Gupta MP, Iwu MM, Madulid DR, Tyler VE 1995. Natural product drug discovery and development: new perspectives on international collaboration. J Nat Prod 58: 1325-1357.
2. Bernai HY, Correa JE 1990. Especies Vegetales Promisorias de los Poises del Convenio Andrés Bello, Tomo VII, Secretaria Ejecutiva del Convenio Andrés Bello, Talleres de Editora Guadalupe Ltda., Bogotá, 480 pp.
3. Betancur-Galvis LA, Saez J, Granados H, Salazar A, Ossa JE 1999. Antitumor and antiviral activity of Colombian medicinal plant extracts, Mem Inst Oswaldo Cruz 94: 531-535.
4. Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB 1987. Evaluation of tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 47: 936-942.
5. Cordell GA 1995. Changing strategies in natural products chemistry. Phytochemistry 40: 1585-1612.
6. Degli Esposti M, Ghelli A, Ratta M, Cortés D, Estomell E 1994. Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitocondrial NADH dehydrogenase (complex I). Biochem J 301: 161-167.
7. Denizot F, Lang R 1986. Rapid colorimetric assay for cell grow and survival modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Meth 89: 211-217.
8. Falsone G, Crea AE, Noack EA 1982. Constituents of Euphorbiaceae, 7.20-Deoxyingenol Monoesters and ingenol diesters from Euphorbia biglandulosa Desf. Arch Pharm (Weinheim) 12: 1026-1032.
9. Fatope MO, Zeng L, Ohayaga JE, Shi G, McLaughlin JL 1996. Selectively cytotoxic diterpenes from Euphorbia poisonii. J Med Chem 39: 1005-1008.
10. Garcia-Barriga H 1974. Flora Medicinal de Colombia. Botánica Médica, 2da ed., Universidad Nacional de Colombia, Talleres Editoriales de la Imprenta Nacional, Santa fé de Bogota, 562 pp.
11. Kusumoto IT, Nakabayashi T, Kida H, Miyashiro H, Hattori M, Namba T, Shimotohno K 1995. Screening of various plant extracts used in ayurvedic medicine for inhibitory effects on human immunodeficiency virus type 1(HIV-1) protease. Phytotherapy Res 9: 180-184.
12. Itokawa H, Ichihara Y, Watanabe K, Takeya K 1989. An antitumor principle from Euphorbia lathyris. Planta Med 55: 271-272.
13. Lorenz RJ, Bögel K 1973. Laboratory techniques in rabies. In MM Kaplan, H Koprowski (eds), Laboratory Techniques in Wrology, World Health Organization, Geneva, 321 pp.
14. Mosmann T 1983. Rapid colorimetric assay for cellular grow and survival: application to proliferation and cytotoxicity assays. J Immunol Meth 65: 55-63.
15. Ninomiya Y, Shimma N, Ishitsuka H 1990. Comparative studies on the antirhinovirus activity and the mode action of the rhinovirus capsid binding agents chalcone amides. Antiviral Res 13: 61-74.
16. Noack EA, Crea AE, Falsone G 1980. Inhibition of mitochondrial oxidative phosporylation by 4-deoxyphorbol triester, a poisonous constituent of the latex of Euphorbia biglandulosa Desf. Toxicon 18: 165-174.
17. Pérez E 1975. Plantas Medicinales y Venenosas De Colombia. Estudio Batánico, Ėtnico, Farmacéutico, Veterinario y Forence, Hernan Salazar, Medellin, 186 pp.
18. Piñeros J, Garcia-Barriga H, Irequi A, Prias E, Perdomo C, Pueta HF 1992. Plantas Medicinales, Compendio de Farmacologia Vegetal, 2da ed., Escuela de Medicina Juan N. Corpas, Fondo Editorial Universitario, Santa Fé de Bogota, 211 pp.
19. Rubinstein LV, Shoemake RH, Paull KD, Simon RM, Tosint S, Skehan P, Scudiero DA, Monks A, Boy MR 1990. Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel human tumor cell lines. J Nat Cancer Inst 82: 1113-1118.
20. Tona L, Kambu K, Mesia K, Cimanga K, Apers S, De Bruyne T, Pieters L, Totte J, Vlietinck AJ 1999. Biological screening of traditional preparations from some medicinal plants used as antidiarrhoeal in Kinshasa, Congo. Phytomedicine 6: 59-66.
21. Unander DW, Webster GL, Blumberg BS 1995. Usage and bioassays in Phyllanthus (Euphorbiaceae). IV. Clustering of antiviral uses and other effects. J Ethnopharmacol 45: 1-18.
22. Van Hoof L, Vanden Berghe DA, Hatfield GM, Vlietinck AJ 1984. Plant antiviral agents. V. 3-methoxyflavones as potent inhibitors of viral induced block of cell synthesis. Planta Med 50: 513-517.
23. Vasquez ML 1982. Euphorbia lanthyris. Plantas y Frutas Medicinales de Colombia y America, Editorial Climent, CaliColombia, 245 pp.
24. Vlietinck AJ, Van Hoof L, Totté J, Lasure A, Vanden Berghe D, Rwangabo PC, Mvukiyumwami J 1995. Screening of hundred Rwandese medicinal plants for antimicrobial and antiviral properties. J Ethnopharmacol 46: 31-47.
25. Vlietinck AJ, Vanden Berghe DA, Van Hoof LM, Vrijsen R, Boeye A 1986. Antiviral activity of 3-methoxyflavones. Prog Clin Biol Res 213: 537-540.
26. Weislow OW, Kiser R. Fine D, Bader J, Shoemaker RH, Boyd MR 1989. New soluble-formazan assay forHIV-1 cytopathic effects: application to high-flux screening of synthetic and natural products for AIDS-antiviral activity. J Natl Cancer Inst 81: 577-586.
27. Wiltink EHH, Janknegt R 1991. Antiviral drugs. Pharmaceutisch Weekblad Scientific Ediction 13: 58-68.
28. Wu TS, Lin YM, Haruna M, Pan DJ, Shingu T, Chen YP, Hsu HY, Nakano T, Lee KH 1991. Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui. J Nat Prod 54: 823-829.
29. Zafra-Polo MC, Gonzáles MC, Estornell E, Sahpaz S, Cortés D 1996. Acetogenins from Annonaceae, inhibitor of mitocondrial complex I. Phytochemistry 42: 253-271.