Structure-activity relationships (SAR) of [D-Arg2]dermorphin(1 - 4) analogues, Nα-amidino-Tyr-D-Arg-Phe-X

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 6, 2002, Pages 771-780

  Ogawa, Tadashi ^a   Miyamae, Tetsuhisa ^a   Okayama, Toru ^a   Hagiwara, Masaki ^a   Sakurada, Shinobu ^b   Morikawa, Tadanori ^a  

^a Daiichi Fine Chemical Co Ltd   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

ADAMB; Analgesic activity; D Arg2 dermorphin analogue; Opioid peptide; Oral administration; SAR

Indexed keywords

AMIDE; BETA AMINO ACID; CARBON; CARBOXYL GROUP; DERMORPHIN DERIVATIVE; MORPHINE; ANALGESIC AGENT; OLIGOPEPTIDE; PEPTIDE; TYROSYL ALANYL PHENYLALANYL GLYCINE; TYROSYL-ALANYL-PHENYLALANYL-GLYCINE;

AMIDATION; AMINO ACID COMPOSITION; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL BOND; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; EXAMINATION; METHYLATION; MOUSE; NONHUMAN; PRESSURE; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; TAIL; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; MALE; ORAL DRUG ADMINISTRATION; SYNTHESIS;

ADMINISTRATION, ORAL; AMINO ACID SUBSTITUTION; ANALGESICS; ANIMALS; MALE; MICE; OLIGOPEPTIDES; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036595080     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.771     Document Type: Article

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