Increased basal nitric oxide release despite enhanced free radical production in hypertension

Journal of Hypertension

Volumn 20, Issue 6, 2002, Pages 1135-1142

  Maffei, Angelo ^a   Poulet, Roberta ^a   Vecchione, Carmine ^a   Colella, Salvatore ^a   Fratta, Luigi ^a   Frati, Giacomo ^a   Trimarco, Valentina ^a   Trimarco, Bruno ^a   Lembo, Giuseppe ^a  

^a IRCCS NEUROMED   (Italy)

Author keywords

Arteries; DAF; Endothelium; Free radicals; Hypertension; Nitric oxide

Indexed keywords

ACETYLCHOLINE; ANTIOXIDANT; ASCORBIC ACID; FLUORESCEIN DERIVATIVE; FREE RADICAL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; 4,5 DIAMINOFLUORESCEIN; 4,5-DIAMINOFLUORESCEIN; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ENZYME INHIBITOR; FLUORESCEIN;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FLUOROMETRY; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TECHNIQUE; ANIMAL; AORTA; DRUG EFFECT; IN VITRO STUDY; MESENTERIC ARTERY; METABOLISM; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

ACETYLCHOLINE; ANIMALS; ANTIOXIDANTS; AORTA; ASCORBIC ACID; ENZYME INHIBITORS; FLUORESCEIN; HYPERTENSION; INDICATORS AND REAGENTS; MALE; MESENTERIC ARTERIES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; REACTIVE OXYGEN SPECIES;

EID: 0036591593     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200206000-00025     Document Type: Article

References (33)

1. Biosynthesis and action of nitric oxide in mammalian cells
2. Molecular control of nitric oxide synthases in the cardiovascular system
3. Neural nitric oxide signaling
4. Nitric oxide and platelet aggregation
5. Erratic behavior of nitric oxide within the immune system: Illustrative review of conflicting data and their immunopharmacological aspects
6. Nitric oxide in the regulation of blood flow and arterial pressure
7. Signal transduction of eNOS activation
8. Direct in situ measurement of nitric oxide in mesenteric resistance arteries. Increased decomposition by superoxide in hypertension
9. Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats
10. Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension
11. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat
12. Alterations to the nitric oxide pathway in the spontaneously hypertensive rat
13. Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats
14. Nitric oxide-dependent vasodilation in young SHR
15. Vasoconstriction to endogenous endothelin-1 is increased in the peripheral circulation of patients with essential hypertension
16. Alteration of nitric oxide synthase expression with aging and hypertension in rats
17. Influence of hypertension on nitric oxide synthase expression and vascular effects of lipopolysaccharide in rat mesenteric arteries
18. Insulin action is associated with endothelial function in hypertension and type2 diabetes
19. Reduced plasma concentration of nitrogen oxide in individuals with essential hypertension
20. Downregulation of soluble guanylyl cyclase in young and aging SHR
21. Detection and imaging of nitric oxide with novel fluorescent indicators: Diaminofluoresceins
22. Inhibition of adrenal cell aldosterone synthesis by endogenous nitric oxide release
23. Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase
24. Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats
25. Adventitia as a source of inducible nitric oxide synthase in the rat aorta
26. Adventitia-derived nitric oxide in rat aortas exposed to endotoxin: Cell origin and functional consequences
27. Noradrenergic vascular hyper-responsiveness in human hypertension is dependent on oxygen free radical impairment of nitric oxide activity
28. Effects of antioxidant therapy on blood pressure and NO synthase expression in hypertensive rats
29. Superoxide anion production is increased in a model of genetic hypertension: Role of the endothelium
30. Oxygen radicals in cerebral vascular injury
31. Redox signals that regulate the vascular response to injury
32. Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase
33. Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin