Prevalence of GAD antibodies in Tunisian type 1 diabetic children;Prevalence des auto anticorps anti-GAD chez des enfants tunisiens diabetiques de type 1

Tunisie Medicale

Volumn 80, Issue 5, 2002, Pages 281-285

  Elkadhi, Amina ^a   Khelifi, Nejib ^a   Abid, Abdelmagid ^a   Nagati, Khemais ^a   Jenhani, Faouzi ^b   Ben Rayana, Mohamed Chiheb ^a  

^a Institut National de Nutrition Tunis   (Tunisia)

^b Centre National de Transfusion Sanguine Tunis   (Tunisia)

Author keywords

Autoimmunity; GAD antibodies; ICA; Type 1 diabetes

Indexed keywords

ANTINUCLEAR ANTIBODY; GLUTAMATE DECARBOXYLASE ANTIBODY; MICROSOME ANTIBODY; PANCREAS ISLET CELL ANTIBODY; THYROID ANTIBODY; AUTOANTIBODY; AUTOANTIGEN; BIOLOGICAL MARKER; GLUTAMATE DECARBOXYLASE; IODIDE PEROXIDASE; IRON BINDING PROTEIN; TPO PROTEIN, HUMAN;

ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE DURATION; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PREDICTION; ADOLESCENT; BLOOD; CASE CONTROL STUDY; CHILD; EPIDEMIOLOGY; IMMUNOLOGY; METABOLISM; PREDICTION AND FORECASTING; TIME; TUNISIA;

ADOLESCENT; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; AUTOANTIGENS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD; DIABETES MELLITUS, TYPE 1; GLUTAMATE DECARBOXYLASE; HUMANS; IODIDE PEROXIDASE; IRON-BINDING PROTEINS; PREDICTIVE VALUE OF TESTS; SEROEPIDEMIOLOGIC STUDIES; TIME FACTORS; TUNISIA;

EID: 0036589511     PISSN: 00414131     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. rautoantibodies as predictors of insulin-dependent diabetes. Lancet 1990;335:1357-60.
2. Baekkeskov S, Aanstoot HJ, Chritgau S, Reetz A, Solimena M, Cascalho M, Folli F.H. Richter-Olesen and Pietro-De Camilli. Identification of the 64K autoantigen in insulin-dependent diabetes as the Gaba-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; (sep); Vol347.
3. Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, and Tobin AJ. Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J. Clin. Invest. 1992;89:283-292.
4. Kaufman DL and Tobin AJ. Glutamate decarboxylase and autoimmunity in insulin-dependent diabetes. TIPS 1993; April; Vol 14.
5. Aanstoot H, Christgou S, Shi Y, Kim J, Begley K, Baekkeskov S. Incidence of autoantibodies to GAD64 and GAD67 in newly diagnosed typel diabetic patients and prediabetic individuals. Diabetologia 1992; 35 (suppl. 1)50A.
6. Rowley MJ, Mackay IR, Chen QY, Knowles WJ, Zimmet PZ. Antibodies to glutamic acid decarboxylase descriminate major types of diabetes mellitus. Diabetes 1992; 41:548-551.
7. Seissler J, Amann J, Mauch L, Haubruck H, Wolfahrt S, Bieg S, Richter W, Holl R, Heinze E, Northemann W, and Scherbaum WA. Prevalence of autoantibodies to the 65-and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J. Clin. Invest 1993; 92:1394-1399.
8. Petersen JS, Hejnaes KR, Moody A, Karlsen AE, Marshall MO, Hoier-Madsen M, Boel E, Michesen BK, and Dyrberg T. Detection of GAD65 Antibodies in diabetes and other autoimmune diseases using a simple radio ligand assay. Diabetes 1994; March;Vol.43.
9. Brigges D, Stephens C, Vaughan R, Walsh K, Black C. A molecular and serolohical anaalysis of the major histocompatibility complex and complement component C4in systemic sclerosis. Arthrits-rheum 1993; 36:943-54.
10. Myers MA, Rabin DU, and Rowley MJ. Pancreatic islet cell cytoplasmic antibody in diabete is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase. Diabetes 1995; Novembre, Vol. 44.
11. rislet cell protein in swidish children with newly diagnosed type I (insulin dependent diabetes). Diabetologia 1988; 31:597-602.
12. Chen QY, Rowley MJ, Byrne GC, Jones TW, Tuomi T, Knowles WJ, Zimmet PZ, and Macakay IR. Antibodies to glutamic acid decarboxylase in australien children with insulin-dependent diabetes mellitus and their first-degree relatives. Pediatr Res 1993; 34: 785-790.
13. Kawasaki E, Takino H, Yano M, Uotoni S, Matsumoto K, Takao Y, Yamaguchi Y, Akazawa S, and Nagataki S. Autoantibodies to Glutamic Acid Decarboxylase in patients with IDDM and autoimmune Thyroid diseases. Diabetes 1994; January; Vol 43.
14. Gepts W, Demey J. Islet cell survival determined by morphology:An immunocytochemical study of the islet of langerhans in juvenile diabetes mellitus. Diabetes 1987;27:251-261.
15. Boitard C, Bonifacio E, Bottazzo GF, Gleichman H, Mohemaar J. Immunologie and diabetes workshop. Report of the third international workshop on the standardisation of cytoplasmic islet cell antibodies. Diabetologia 1988;31:451-2.
16. Bonifacio E, Genovese S, Bazzigaluppi S, Lampasona V, Bingley PJ, L Rogge, Pastore MR, Bognetti E, Bottazzo GF, Gale EA, Bosi E. Islet antibody markers in IDDM: Risk assessment strategies yielding high sensitivity. Diabetologia 1995;38:816-22.
17. Vardi P, Dibela EE, Pasquare Plot T.J, Scikanta S. Islet cell autoantibodies: Pathobiology and clinical application. Diabetes Care 1987;10:645-56.
18. Humbel RL, Guillame AC, Schmit P, Gilson G, Beauort C, Michel G, Mauch L. Etude de diffėrentes mėthodes pour la mise en évidence des autoanticorps anti-glutamate-décarboxylase associés au developpement du diabėte insulinodependant. Immunoanal Biol Spéc 1998; 12:275-279.
19. 65 autoantibodies, a key risk-assessement marker for insulin-dependent diabetes mellitus. Clinical Chemistry 1996; 42:2; 263-269.
20. Ongagna J-C, Levy-Marchal C. (). Sensitivity at diagnosis of combined beta-cell antibodies in insulin-dependent diabetic children. Diabetes and Metabolism 1997; 23: 155-160.