Coronary artery disease and dyslipidemia within Europe: Genetic variants in lipid transport gene loci in German subjects with premature coronary artery disease

Atherosclerosis Supplements

Volumn 3, Issue 1, 2002, Pages 27-33

  Kay, A ^a   Marz W ^b   Hoffmann, M M ^b   Zhang, Q ^a   Masana, L I ^c   Cavanna, J ^a   Baroni, M G ^b   Shine, B ^a   Galton, D J ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF FREIBURG   (Germany)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Coronary artery disease; Dyslipidemia; Genetic predisposition

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; APOLIPOPROTEIN C3; APOLIPOPROTEIN E; LIPOPROTEIN LIPASE; LIVER TRIACYLGLYCEROL LIPASE;

ADULT; CHOLESTEROL BLOOD LEVEL; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; DYSLIPIDEMIA; GENE FUNCTION; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GERMANY; HUMAN; ISCHEMIC HEART DISEASE; LIPID TRANSPORT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PHENOTYPE; PRIORITY JOURNAL; ARTICLE; CORONARY ARTERY ATHEROSCLEROSIS; GENE FREQUENCY; GENETICS; HYPERLIPIDEMIA; LIPID METABOLISM; MIDDLE AGED; TRANSPORT AT THE CELLULAR LEVEL;

ADULT; BIOLOGICAL TRANSPORT; CORONARY ARTERIOSCLEROSIS; GENE FREQUENCY; GERMANY; HUMANS; HYPERLIPIDEMIAS; LIPID METABOLISM; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; VARIATION (GENETICS);

EID: 0036583680     PISSN: 15675688     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5688(01)00003-4     Document Type: Conference Paper

References (31)

1. Sans S., Kesteloot H., Kromhout D. The burden of cardiovascular diseases mortality in Europe. Task Force of the European Society of Cardiology on Cardiovascular Mortality and Morbidity Statistics in Europe. Eur. Heart J. 18:(8):1997;1231-1248.
2. Berg K. Twin studies of coronary heart disease and its risk factors. Acta Genet. Med. Gemellol (Roma). 33:(3):1984;349-361.
3. Cambien F., Poirier O., Lecerf L., et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature. 359:(6396):1992;641-644.
4. Mattu R., Needham E., Galton D., Frangos E., Clark A., Caulfield M. A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study [see comments]. Circulation. 91:(2):1995;270-274.
5. Berge K., Berg K. No effect of insertion/deletion polymorphism at the ACE locus on normal blood pressure level or variability. Clin. Genet. 45:(4):1994;169-174.
6. Saha N., Talmud P., Tay J., Humphries S., Basair J. Lack of association of angiotensin-converting enzyme (ACE). Gene insertion/deletion polymorphism with CAD in two Asian populations. Clin. Genet. 50:(3):1996;121-125.
7. Fornage M., Turner S., Sing C., Boerwinkle E. Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from Rochester, Minnesota. Hum. Genet. 96:(3):1995;295-300.
8. Utermann G., Hardewig A., Zimmer F. Apolipoprotein E phenotypes in patients with myocardial infarction. Hum. Genet. 65:(3):1984;237-241.
9. Ferns G., Galton D. Haplotypes of the human apoprotein AI-CIII-AIV gene cluster in coronary atherosclerosis. Hum. Genet. 73:(3):1986;245-249.
10. Chamberlain J., Galton D. Genetic susceptibility to atherosclerosis. Br. Med. Bull. 46:(4):1990;917-940.
11. Berg K., Dahlen G., Christophersen B., Cook T., Kjekshus J., Pedersen T. Lp(a) lipoprotein level predicts survival and major coronary events in the Scandinavian Simvastatin Survival Study. Clin. Genet. 52:(5):1997;254-261.
12. Chamberlain J., Thorn J., Morgan R., Bishop A., Stocks J., Rees A., Oka K., Galton D. Genetic variation at the lipoprotein lipase gene associates with coronary arteriosclerosis. Adv. Exp. Med. Biol. 285:1991;275-279.
13. Galton D., Mattu R., Needham E., Cavanna J. Identification of putative beneficial mutations for lipid transport. Z. Gastroenterol. 34:(Suppl 3):1996;56-58.
14. Hata A., Emi M., Luc G., Basdevant A., Gambert P., Iverius P., Lalouel J. Direct detection and automated sequencing of individual alleles after electrophoretic strand separation: identification of a common nonsense mutation in exon 9 of the human lipoprotein lipase gene. Nucleic Acids Res. 18:(18):1990;5407-5411.
15. Stocks J., Thorn J., Galton D. Lipoprotein lipase genotypes for a common premature termination codon mutation detected by PCR-mediated site-directed mutagenesis and restriction digestion. J. Lipid Res. 33:(6):1992;853-857.
16. Zhang Q., Cavanna J., Winkelman B., et al. Common genetic variants of lipoprotein lipase that relate to lipid transport in patients with premature coronary artery disease. Clin. Genet. 48:(6):1995;293-298.
17. Schweder Y., Spjotvoll E. Plots of P-values to evaluate many tests simultaneously. Biometrika. 69:1982;493-502.
18. Parker R., Rothenberg R. Identifying important results from multiple statistical tests. Stat. Med. 7:1988;1031-1043.
19. Hokanson J. Functional variants in the lipoprotein lipase gene and risk cardiovascular disease. Curr. Opin. Lipidol. 10:(5):1999;393-399.
20. Ehnholm C., Lukka M., Kuusi T., Nikkila E., Utermann G. Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. J. Lipid Res. 27:(3):1986;227-235.
21. Hallman D., Boerwinkle E., Saha N., et al. The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations [see comments]. Am. J. Hum. Genet. 49:(2):1991;338-349.
22. Groenemeijer B., Hallman M., Reymer P., et al. Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients. The Ser447-stop substitution in the lipoprotein lipase gene. REGRESS Study Group [see comments]. Circulation. 95:(12):1997;2628-2635.
23. Humphries S., Nicaud V., Margalef J., Tiret L., Talmud P. Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS). Arterioscler. Thromb. Vasc. Biol. 18:(4):1998;526-534.
24. Humphries S., Nicaud V., Margalef J., Tiret L., Talmud P. Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III, A-IV gene locus. Relationships with lipids, apolipoproteins, and premature coronary artery disease. Atherosclerosis. 87:(1):1991;75-86.
25. Vavatsi N., Kouidou S., Geleris P., et al. Increased frequency of the rare PstI allele (P2) in a population of CAD patients in northern Greece. Clin. Genet. 47:(1):1995;22-26.
26. Turner P., Talmud P., Visvikis S., Ehnholm C., Tiret L. DNA polymorphisms of the apoprotein B gene are associated with altered plasma lipoprotein concentrations but not with perceived risk of cardiovascular disease: European Atherosclerosis Research Study. Atherosclerosis. 116:(2):1995;221-234.
27. Porkka K., Taimela S., Kontula K., et al. Variability gene effects of DNA polymorphisms at the apo B, apo A I/C III and apo E loci on serum lipids: the Cardiovascular Risk in Young Finns Study. Clin. Genet. 45:(3):1994;113-121.
28. Galton D. Common genetic determinants of dyslipidemia: the hypertriglyceridemia/low-high-density lipoprotein syndrome. J. Cardiovasc. Pharmacol. 25:(Suppl. 4):1995;S35-S40.
29. Mitchell R., Earl L., Bray P., Fripp Y., Williams J. DNA polymorphisms at the lipoprotein lipase gene and their association with quantitative variation in plasma high-density lipoproteins and triacylglycerides. Hum. Biol. 66:(3):1994;383-397.
30. Gerdes C., Gerdes L., Hansen P., Faergeman O. Polymorphisms in the lipoprotein lipase gene and their associations with plasma lipid concentrations in 40-year-old Danish men. Circulation. 92:(7):1995;1765-1769.
31. Galton D. Genetic determinants of atherosclerosis-related dyslipidemias and their clinical implications. Clin. Chim. Acta. 257:(2):1997;181-197.