The role of glycosyl phosphatidyl inositol (GPI)-anchored cell surface proteins in T-cell activation

Transplant Immunology

Volumn 9, Issue 2-4, 2002, Pages 93-96

  Loertscher, Rolf ^a   Lavery, Paula ^a  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

CD28; Co stimulation; Glycolipid membrane rafts; GPI linked proteins; T lymphocyte activation

Indexed keywords

CD28 ANTIGEN; GLYCOSYLPHOSPHATIDYLINOSITOL; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; ACTIN; ANTIBODY; ANTIGEN; CALCIUM; CD48 ANTIGEN; CD59 ANTIGEN; CELL SURFACE PROTEIN; LY 6A ANTIGEN; LY 6E ANTIGEN; LYMPHOKINE; PROTEIN TYROSINE KINASE; SPHINGOLIPID; T LYMPHOCYTE RECEPTOR; THY 1 ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PHYSIOLOGY; REVIEW; T LYMPHOCYTE; ANTIBODY SPECIFICITY; CALCIUM TRANSPORT; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CYTOSKELETON; EMBRYO DEVELOPMENT; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; METABOLIC REGULATION; MITOGENESIS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SYNAPSE; T LYMPHOCYTE ACTIVATION; TISSUE DISTRIBUTION;

ANIMALS; ANTIGENS, CD28; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; ANIMAL; HUMAN; SUPPORT, NON-U.S. GOV'T;

EID: 0036582493     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-3274(02)00013-8     Document Type: Review

References (27)

1. Lineage determination of CD7 + CD5-CD2- and CD7 + CD5 + CD2- lymphoblasts: Studies on phenotype, genotype, and gene expression of myeloperoxidase, CD3 epsilon, and CD3 delta
2. Integration of T cell receptor-dependent signaling pathways by adaptor proteins
3. GPI microdomains: A role in signalling via immunoreceptors
4. Biosynthesis and processing of the glycosylphosphatidylinositol anchor in mammalian cells
5. Defective glycosyl phosphatidylinositol anchor synthesis and paroxysmal nocturnal hemoglobinuria
6. Mechanism of Thy-1-mediated T cell activation: Roles of Fc receptors, T200, Ia, and H-2 glycoproteins in accessory cell function
7. T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4
8. Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes
9. GPI-anchored cell-surface molecules complexed to protein tyrosine kinases
10. Cellular isoform of the scrapie agent protein participates in lymphocyte activation
11. Glycolipid anchors are attached to Thy-1 glycoprotein rapidly after translation
12. Role of Ly-6A/E and T cell receptor-ζ for IL-2 production
13. Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function
14. A glycophospholipid anchor is required for Qa-2-mediated T cell activation
15. Role of Ly-6 in lymphocyte activation. Induction of T cell activation by monoclonal anti-Ly-6 antibodies
16. Regulation of T lymphocyte function by glycosyl-phosphatidylinositol (GPI)-anchored proteins
17. Glycosylphosphatidylinositol-anchor-deficient mice: Implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria
18. Role of phosphatidylinositol-anchored proteins in T cell activation
19. Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene
20. Defective TCR signaling events in glycosylphosphatidylinositol-deficient T cells derived from paroxysmal nocturnal hemoglobinuria patients
21. Impaired cutaneous immune responses in Thy-1-deficient mice
22. The nature of large non-covalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases
23. Microdomains of GPI-anchored proteins in living cells revealed by cross-linking
24. Functionally different GPI proteins are organized in different domains on the neuronal surface
25. The immunological synapse: A molecular machine controlling T cell activation
26. Floating the raft hypothesis: Lipid rafts play a role in immune cell activation