Stereoselective pharmacokinetics of BOF-4272 racemate after oral administration to rats and dogs

Biological and Pharmaceutical Bulletin

Volumn 25, Issue 5, 2002, Pages 674-677

  Naito, Shinsaku ^a   Nishimura, Masuhiro ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

BOF 4272; Hepatic uptake; Oral administration; Stereoselectivity; Sulphoxide containing drug; Xanthine oxidase inhibitor

Indexed keywords

8 [3 METHOXY 4 (PHENYLSULFINYL)PHENYL]PYRAZOLO[1,5 A][1,3,5]TRIAZIN 4 OL; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; DRUG UPTAKE; ENANTIOMER; EXPERIMENTAL MODEL; INTESTINE ABSORPTION; KIDNEY; LIVER; MALE; NONHUMAN; PORTAL VEIN; RAT; STEREOCHEMISTRY; SYSTEMIC CIRCULATION; VENOUS BLOOD; ANIMAL; COMPARATIVE STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; METABOLISM; STEREOISOMERISM; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; KIDNEY; LIVER; MALE; RATS; RATS, WISTAR; STEREOISOMERISM; TRIAZINES;

EID: 0036581645     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.25.674     Document Type: Article

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