The antioxidant properties of thyme (thymus zygis L.) essential oil: An inhibitor of lipid peroxidation and a free radical scavenger

Journal of Essential Oil Research

Volumn 14, Issue 3, 2002, Pages 210-215

  Youdim, K A ^a   Deans, S G ^a   Finlayson, H J ^b  

^a SCOTTISH AGRICULTURAL COLLEGE   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Antioxidant; Free radicals; Lamiaceae; Lipid peroxidation; Pro oxidant; Thyme oil; Thymol; Thymus zygis

Indexed keywords

ANTIOXIDANTS; CELL MEMBRANES; FREE RADICALS; LIPIDS; OXIDATION;

LIPID PEROXIDATION;

ESSENTIAL OILS;

EID: 0036571255     PISSN: 10412905     EISSN: None     Source Type: Journal    
DOI: 10.1080/10412905.2002.9699825     Document Type: Article

References (34)

1. B. Halliwell and J. M. C. Gutteridge, Free Radicals in Biology and Medicine. 2nd Edition, Clarendon Press, Oxford (1989).
2. R.S. Sohal and W.C. Orr, Relationship between antioxidants, prooxidants, and the aging process. Ann. Acad. Sci., 663, 74-84 (1992).
3. B.M. Crandall and G.W. Arendash, Chronic antioxidant treatment improves the cognitive performance in aged rats. Brain Res., 693,88-94 (1995).
4. G. Barjade Quiroga, R. Perez-Campo and M. Lopez-Torres, Antioxidant defences and peroxidation in liver and brain of aged rats. Biochem. J., 272, 247-250 (1990).
5. G. Barjade Quiroga, M. Lopez-Torres and R. Perez-Campo, Relationship between antioxidants, lipid peroxidation and aging. In: Free Radicals and Aging. Edits., I. Emerit and B. Chance, pp. 109-124, Birkhauser Verlag Basel, Switzerland (1992).
6. C.D. Stubbs and A.D. Smith, The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim. Biophys. Acta, 779, 89-137 (1984).
7. B.M. Cohen and G.S. Zubenko, Aging and the biophysical properties of cell membranes. Life Sci.,7,1403-1409 (1985).
8. A.A. Spector and M.A. Yoerk, Membrane lipid composition and cellular function. J. Lipid Res., 26, 1015-1035 (1985).
9. M. Neuringer, G.J. Anderson and W.E. Connor, The essentiality of n-3 fatty acids for the development and function on the retina and brain. Ann. Rev. Nutri., 8, 517-541 (1988).
10. N. Salem Jr., Omega-3 fatty acids: molecular and biochemical aspects. In: New Protective Roles for Selected Nutrients. Edits. G. Spiller and J. Scala, pp. 109-228, Alan R. Liss, Inc., Wiley Chichester (1989).
11. L.B. Wingard Jr., T.M. Brody, J. Larner and A. Schwartz, In: Human Pharmacology: Molecular to Clinical. Edit. K. Kist, pp. 360-373, Wolfe Publishing Limited, International Student Edition, London (1991).
12. J.J. Yunis, The chromosomal basis of human neoplasia. Science, 221, 227-236 (1983).
13. J.C. Fantone, and P.A. Ward, Role of oxygen derived free radicals and metabolites in leukocyte dependant inflammatory reactions. Amer. J. Pathol., 107, 397-418 (1982).
14. J.M. McCord, Free radicals and inflammation: Protection of synovial fluid by superoxide dismutase. Science, 185, 529-531 (1974).
15. C.E. Eriksson, Autoxidation of Unsaturated Lipids, Academic Press, London, (1987).
16. H. Witschl, A.M. Malkinson and J.A. Thomson, Metabolism and pulmonary toxicity of butylatedhydroxytoluene (BHT). Pharmacol. Ther., 42,89 (1989).
17. R. Aeschbach, J. Loliger, B.C. Scott, A. Murcia, J. Butler, B. Halliwell and O.L. Aruoma, Antioxidant actions of thymol, carvacrol, 6-gingeroi, zingerone and hydroxytyrosol. Food Chem. Toxic., 32, 31-36 (1994).
18. O.L. Aruoma, B. Halliwell, R. Aeschbach and J. Loliger, Antioxidant and pro-oxidant properties of active rosemary constituents: camosot and carnosic acid. Xenobio., 22, 257-268 (1992).
19. H.L. Madsen and G. Bertelsen, Spices as antioxidants. TIFST, 6, 271-277 (1995).
20. S.G. Deans and G. Ritchie, Antibacterial properties of plant essential oils. Int. J. Food Microbiol., 5, 165-180 (1987).
21. S.G. Deans, Evaluation of antimicrobial activity of essential oils. In: Modern Methods of Plant Analysis, Essential Oils and Waxes. Edits. H.F. Llnskens and J.F. Jackson, pp. 85-91, Springer-Verlag, Heidelberg (1991).
22. S.G. Deans and P.G. Waterman, Biological activity of plant volatile oils. In: Volatile Oil Crops Edits. R.K.M. Hay and P.G. Waterman, pp. 113-136, Longman Group UK, London (1993).
23. H.J.D. Dorman, S.G. Deans and R.C. Noble, Evaluation in vitro of plant essential oils as natural antioxidants. J. Essent. Oil Res., 7,645-651 (1995).
24. J.M.C. Gutlerldge, Superoxlde-dependant formation of hydroxyl radicals in the presence of iron salts. Detection of free iron in biological systems by using the bleomycin dependant degradation of DNA. Biochem. J., 206,605-609(1981).
25. O.L. Aruoma, Use of DNA damage as a measure or pro-oxidant actions of antioxidant food additives and nutrient components. In: DNA and Free Radicals. Edits., B. Halliwell and O.l. Aruoma, pp. 315-327, Ellis Horwood, London (1993).
26. I.F.F. Benzie, Lipid peroxidation: a review of causes, consequences, measurement and dietary influences. Int. J. Food Sci. Nutrit., 47, 233-261 (1996).
27. K. Kikugawa, T. Kojima, S. Yamaki and FI. Kosugl, Interpretation of the thiobarbituric acid reactivity of rat liver and brain homogenates in the presence of ferric ion and ethylenediaminetetraacetic acid. Anals Biochem., 202, 249-255 (1992).
28. H. Kosugi, T. Kato and K. Kikugawa, Formation of red pigment by a two step 2-thiobarbituric acid reaction ofalka-2,4-dienals. Potential products of lipid oxidation. Lipids, 23, 1024-1028 (1988).
29. S.G. Deans, R.C. Noble, A. Macpherson, L. Penzes and S.G. Imre, A new type of approach to modify lipid patterns in ageing mice. Natural antioxidants of plant origin. In: Aspects of Ageing and Disease. Edits., D.L. Knook and G. Flofecker, pp. 173-177, Facultas Unlversitatsverlag, Vienna (1994).
30. th Flavour Conference, American Chemical Society, Greece, July (1994).
31. W.M. Cort, Hemoglobin peroxidation test screens antioxidants. Food Technol. Oct, 60-66 (1974).
32. M. Tsimidou and D. Boskou, Antioxidant activity of essential oils from plants of the Lamiaceae family. In: Spices, Herbs and Edible Fungi. Edit., G. Charalambous, pp. 273-284, Elsevier Science B.V., Amsterdam (1994).
33. A. Bindoli, L. Cavallini and P. Jocelyn, Mitochondrial lipid peroxidation by cumene hydroperoxide and its prevention by succinate. Biochim. Biophys Acta, 861, 496-503 (1982).
34. K.A. Youdim, Potential beneficial effects of thyme oil and thymol on aspects of ageing processes. PhD Thesis, University of Strathclyde,Glasgow, Scotland (1997).