Safety, tolerability, and pharmacokinetic effects of thalidomide in patients infected with human immunodeficiency virus: AIDS Clinical Trials Group 267

Journal of Infectious Diseases

Volumn 185, Issue 9, 2002, Pages 1359-1363

  Wohl, David A ^a   Aweeka, Francesca T ^c   Schmitz, John ^b   Pomerantz, Roger ^d   Cherng, Deborah Weng ^f   Spritzler, John ^f   Fox, Lawrence ^g   Simpson, David ^f   Bell, Dawn ^h   Holohan, M K ^h   Thomas, Steven ^j   Robinson, Wayne ^j   Kaplan, Gilla ⁱ   Teppler, Hedy ^e  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e MERCK RESEARCH LABORATORIES   (United States)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^g NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^h SOCIAL AND SCIENTIFIC SYSTEMS INC   (United States)

ⁱ ROCKEFELLER UNIVERSITY   (United States)

^j CELGENE CORPORATION   (United States)

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Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CELGENE; PLACEBO; THALIDOMIDE;

ADULT; APHTHOUS ULCER; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG FORMULATION; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; EDEMA; FATIGUE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MALE; PERIPHERAL NEUROPATHY; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOMNOLENCE; THROMBOCYTOPENIA; TREATMENT OUTCOME; WASTING SYNDROME;

ADULT; ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; DOUBLE-BLIND METHOD; FEMALE; HIV INFECTIONS; HUMANS; MALE; RANDOMIZED CONTROLLED TRIALS; THALIDOMIDE;

EID: 0036569235     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/340133     Document Type: Article

References (15)

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2. Thalidomide for the treatment of esophageal aphthous ulcers in patients with human immunodeficiency virus infection
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4. Thalidomide reverses cachexia in HIV-wasting syndrome
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10. Pharmacokinetics and hemodynamic effects of single oral doses of thalidomide in asymptomatic human immunodeficiency virus-infected subjects
11. Effects of oral thalidomide on rat liver and skin microsomal P450 isoenzyme activities and on urinary porphyrin excretion: Interaction with oral hexachlorobenzene
12. Determination of thalidomide in plasma and blood by HPLC, avoiding hydrolytic degradation
13. A single dose of thalidomide enhances the capacity of lymphocytes to secrete gamma interferon in healthy humans
14. Pharmacokinetics and pharmacodynamics of thalidomide in HIV patients treated with oral aphthous ulcers: AIDS Clinical Trials Group 251
15. Thalidomide does not alter the pharmacokinetics of ethinyl estradiol and norethindrone