The effect of nitric oxide synthase blockade on responses to morphine in rat aortic rings

Autonomic and Autacoid Pharmacology

Volumn 22, Issue 2, 2002, Pages 103-107

  Sahin N ^a   Ozdem S ^a   Sadan G ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Morphine; Nitric oxide; Rat

Indexed keywords

MORPHINE; N(G) NITROARGININE METHYL ESTER; NALOXONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OPIATE RECEPTOR; PHENYLEPHRINE; POTASSIUM CHLORIDE; ENZYME INHIBITOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENDOTHELIUM; MALE; NONHUMAN; PERIPHERAL CIRCULATION; RAT; VASCULAR RING; VASODILATATION; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; THORACIC AORTA; WISTAR RAT;

ANIMALS; AORTA, THORACIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MALE; MORPHINE; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR; VASODILATION;

EID: 0036557242     PISSN: 14748665     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1474-8673.2002.00249.x     Document Type: Article

References (27)

1. BERNSTEİN, M.A. & WELCH, S.P. (1995). Alterations in L-type calcium channels in the brain and spinal cord of acutely treated and morphine tolerant mice. Brain Res., 696, 83-88.
2. CALİGNANO, A., MONCADA, S. & Dİ ROSA M. (1991). Endogenous nitric oxide modulates morphine-induced constipation. Biochem. Biophys. Res. Commun, 181, 889-893.
3. CALİGNANO, A., PERSİCO, P., MANCUSO, F. & SORRENTİNO, L. (1993). Endogenous nitric oxide modulates morphine-induced changes in locomotion and food intake in mice. Eur J. Pharmacol., 231, 415-419.
4. DAVID, C., DAVIS, N., MASON, R. & WILSON, V.G. (1993). Evidence for functional dissociation of dependence and tolerance in guinea-pig isolated ileal segments following 20 hour exposure to morphine in vitro. Br. J. Pharmocol., 110, 1522-1526.
5. DUARTE, I.D. & FERREİRA, S.H. (1992). The molecular mechanism of central analgesia induced by morphine or carbachol and the L-arginine-nitric oxide-cGMP pathway. Eur J. Pharmacol., 221, 171-174.
6. EL SHARKAWY, T.Y., AL SHIREIDA, M.F. & PILCHER, C.W. (1991). Vascular effects of some opioid receptor agonists. Can J. Physiol. Pharmacol., 69, 846-851.
7. FECHO, K., MASLONEK, K.A., COUSSONS-READ, M.E., DYKSTRA, L.A. & LYSLE, D.T. (1994). Macrophage-derived nitric oxide is involved in the depressed concanavalin. A responsiveness of splenic lymphocytes from rats administered morphine in vivo. J. Immunol., 152, 5845-5852.
8. FERREİRA, S.H., DUARTE, I.D. & LORENZETTİ, B.B. (1991). The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release. Eur J. Pharmacol., 201, 121-122.
9. FİELDS, A., GAFNİ, M., ORON, Y. & SARNE, Y. (1995). Multiple effects of opiates on intracellular calcium level and on calcium uptake in three neuronal cell lines. Brain Res., 687, 94-102.
10. FUKAO (1995). Evidence for relative inhibitor by lysophosphatylcholone of acetylcholone-induced endothelium-dependent hyperpolarization and relaxation in rat mesenteric artery. Br. J. Pharmocol., 116, 1541-1544.
11. GYİRES, K. (1994). The role of endogenous nitric oxide in the gastroprotective action of morphine. Eur J. Pharmacol., 255, 33-37.
12. 2+ homeostasis in vascular smooth muscle. J. Vasc Res., 32, 207-219.
13. INTRONA, R.P., BRIDGES, M.T. JR, YODLOWSKI, E.H., GROVER, T.E. & PRUETT, J.K. (1995). Direct effects of fentanyl on canine coronary artery rings. Life Sci., 56, 1265-1273.
14. KİANG, J.G. & COLDEN-STANFİELD, M. (1990). Morphine induces an intracellular alkalinization in bovine aortic endothelial cells (BAECs). Prog. Clin. Biol. Res., 328, 137-140.
15. LEE, C.H. & BERKOWITZ, B.A. (1976). Stereoselective and calcium-dependent contractile effects of narcotic antagonist analgesics in the vascular smooth muscle of the rat. J. Pharmacol. Exp Ther, 198, 347-356.
16. LEE, C.H. & BERKOWITZ, B.A. (1977). Calcium antagonist activity of methadone, l-acetylmethadol and l-pentazocine in the rat aortic strip. J. Pharmacol. Exp Ther, 202, 646-653.
17. MAJEED, N.H., PRZEWLOCKA, B., MACHELSKA, H. & PRZEWLOCKİ, R. (1994). Inhibition of nitric oxide synthase attenuates the development of morphine tolerance and dependence in mice. Neuropharmacology, 33, 189-192.
18. MAKMAN, M.H., BILFINGER, T.V. & STEFANO, G.B. (1995). Human granulocytes contain an opiate alkaloid-selective receptor mediating inhibition of cytokine-induced activation and chemotaxis. J Immunol., 154, 1323-1330.
19. 2+ channel ligands modulate morphine effects on the hypothalamus-pituitary-adrenocortical axis in rats. Eur J. Pharmacol., 232, 191-198.
20. MCDONALD, C.E., GAGNON, M.J., ELLENBERGER, E.A., HODGES, B.L., REAM, J.K., TOUSMAN, S.A. & QUOCK, R.M. (1994). Inhibitors of nitric oxide synthesis antagonize nitrous oxide antinociception in mice and rats. J. Pharmacol. Exp Ther, 269, 601-608.
21. PARRA, L., PEREZ-VINCAINO, F., ALSASUA, A., MARTIN, M.I. & TAMARGO, J. (1995). Mu- and delta-opioid receptor-mediated contractile effects on rat aortic vascular smooth muscle. Eur J. Pharmacol., 227, 99-105.
22. PERSICO, P., CALIGNANO, A., MANCUSO, F. & SORREENTINO, L. (1993). Involvement of NK receptors and beta-adrenoceptors in nitric oxide-dependent relaxation of rabbit aorta rings following electrical-field stimulation. Eur J. Pharmacol., 238, 105-109.
23. PRZEWLOCKİ, R., MACHELSKA, H. & PRZEWLOCKA, B. (1993). Inhibition of nitric oxide synthase enhances morphine antinociception in the rat spinal cord. Life Sci., 53, PL1-5.
24. RIGGS, T.R., YANO, Y. & VARGISH, T. (1986). Morphine depression of myocardial function. Circ. Shock, 19, 31-38.
25. STEFANO, G.B., DIGENIS, A., SPECTOR, S., LEUNG, M.K., BILFINGER, T.V., MAKMAN, M.H., SCHARRER, B. & ABUMRAD, N.N. (1993). Opiate-like substances in an invertebrate, an opiate receptor on invertebrate and human immunocytes, and a role in immunosuppression. Proc. Natl Acad. Sci. USA, 90, 11099-11103.
26. 3 opiate receptor in endothelial cells. J. Biol. Chem., 270, 30290-30293.
27. WELCH, S.P. & OLSON, K.G. (1991). Opiate tolerance-induced modulation of free intracellular calcium in synaptosomes. Life Sci., 48, 1853-1861.