Endogenous dipeptide cycloprolylglycine shows selective anxiolytic activity in animals with manifest fear reaction

Bulletin of Experimental Biology and Medicine

Volumn 133, Issue 4, 2002, Pages 360-362

  Seredenin, S B ^a   Gudasheva, T A ^a   Boiko, S S ^a   Koralev, G I ^a   Voronin, M V ^a   Yarkova, M A ^a  

^a INSTITUTE OF PHARMACOLOGY   (Russian Federation)

Author keywords

Anxiolytic activity; BALB c; C5B1 6; Content in mouse brain; Cycloprolylglycine

Indexed keywords

CYCLOPROLYLGLYCINE; DIPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG EFFECT; EMOTIONAL STRESS; FEAR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLIC REGULATION; MOTOR ACTIVITY; MOUSE; MOUSE STRAIN; NONHUMAN; OPEN FIELD BEHAVIOR; OPEN FIELD TEST; PROTEIN CONTENT; PROTEIN FUNCTION; STRAIN DIFFERENCE; TISSUE LEVEL; TRANQUILIZING ACTIVITY;

ANIMALS; ANXIETY; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEAR; GLYCINE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PEPTIDES, CYCLIC;

ANIMALIA;

EID: 0036554893     PISSN: 00074888     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016293904149     Document Type: Article

References (10)

1. P. M. Borodin, P. Schuler, and R. K. Belyaev, Genetika, No. 12, 62-67 (1976).
2. T. A. Gudasheva, N. I. Vasilevich, R. U. Ostrovskaya, et al., Khim. Farm. Zh., 30, No. 9, 12-17 (1996).
3. T. A. Gudasheva, M. A. Konstantinopol'skii, R. U. Ostrovskaya, and S. B. Seredenin, Byull. Eksp. Biol. Med., 131, No. 5, 547-550 (2001).
4. T. A. Gudasheva, R. U. Ostrovskaya, S. S. Trofimov, et al., Ibid., 128, No. 10, 411-413 (1999).
5. S. B. Seredenin and A. A. Vedernikov, Ibid., 88, No. 7, 38-40 (1979).
6. S. B. Seredenin, T. A. Voronina, G. G. Neznamov, et al., Vestn. Ross. Akad. Med. Nauk, No. 11, 3-9 (1998).
7. T. A. Gudasheva, S. S. Boyko, V. Kh. Akparov, et al., FEBS Lett., 391, 149-152 (1996).
8. T. A. Gudasheva, R. U. Ostrovskaya, T. A. Voronina, and S. B. Seredenin, J. Peptide Sci., No. 6, Suppl., 170-171 (2000).
9. L. G. Kolik, S. B. Seredenin, D. Gaviraghi, et al., Biological Basis of Individual Sensitivity to Psychotropic Drugs, Suzdal (2001), P. 233.
10. S. B. Seredenin, Yu. A. Blednov, B. A. Badishtov, and N. M. Shevchenko, Drug Dependence and Emotional Behavior, Ed. A. V. Valdman, Leningrad (1986), pp. 49-77.