Proteomics for the development of DNA tolerizing vaccines to treat autoimmune disease

Clinical Immunology

Volumn 103, Issue 1, 2002, Pages 7-12

  Robinson, William H ^a,b   Garren, Hideki ^a,b   Utz, Paul J ^a,b   Steinman, Lawrence ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Tolerion   (United States)

Author keywords

Antigen specific therapy; Autoantibodies; Autoimmune disease; DNA vaccines; Protein arrays

Indexed keywords

DNA; DNA VACCINE; AUTOANTIBODY; PROTEOME;

ANTIGEN SPECIFICITY; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONFERENCE PAPER; DIABETES MELLITUS; GENOMICS; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE; MULTIPLE SCLEROSIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEOMICS; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; TISSUE INJURY; TREATMENT PLANNING; ANIMAL; BIOSYNTHESIS; COST BENEFIT ANALYSIS; HUMAN; IMMUNOLOGY; REVIEW;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; COST-BENEFIT ANALYSIS; HUMANS; PROTEOME; T-LYMPHOCYTES; VACCINES, DNA;

EID: 0036548967     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2002.5185     Document Type: Conference Paper

References (48)

1. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
2. Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial
3. Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial
4. DNA vaccines
5. Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway
6. DNA vaccination in the treatment of autoimmune disease
7. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire
8. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry
9. Autoantibodies in the diagnosis of systemic rheumatic diseases
10. Identification of autoantibodies associated with myelin damage in multiple sclerosis
11. Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: The minimal B cell epitope and a model of its unique features
12. Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis
13. Major peptide autoepitopes for nucleosome-specific T cells of human lupus
14. Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes
15. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
16. Proteomics technologies to study autoimmune disease
17. Autoantibody profiling for the study and treatment of autoimmune disease
18. Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions
19. Autoantigen microarrays for multiplex characterization of autoantibody responses
20. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library
21. Light-directed, spatially addressable parallel chemical synthesis
22. Single step generation of protein arrays from DNA by cell-free expression and in situ immobilisation (PISA method)
23. A model of peptide-induced lupus autoimmune B cell epitope spreading is strain specific and is not H-2 restricted in mice
24. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
25. Microarrays of cells expressing defined cDNAs
26. Advanced multiplexed analysis with the FlowMetrix system
27. Submicrometer metallic barcodes
28. Liquid flows in microchannels
29. Suppressive immunization with DNA encoding a self-protein prevents autoimmune disease: Modulation of T cell co-stimulation
30. Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice
31. Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice
32. Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection
33. DNA vaccines for the treatment of autoimmune disease
34. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization
35. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes
36. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
37. DNA immunization to prevent autoimmune diabetes
38. The underestimated long term medical and economic consequences of rheumatoid arthritis
39. The natural history of multiple sclerosis: Update 1998
40. Epitope-specific suppression of antibody response in experimental autoimmune myasthenia gravis by a monomethoxypolyethylene glycol conjugate of a myasthenogenic synthetic peptide
41. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis
42. Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy
43. Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85 VVHFFKNIVTP96 in chronic progressive multiple sclerosis
44. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
45. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
46. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
47. Treatment of systemic lupus erythematosus with LJP 394
48. Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens