Gastrin interferes with the differentiation of gastric pit cells and parietal cells

Alimentary Pharmacology and Therapeutics, Supplement

Volumn 16, Issue 2, 2002, Pages 3-9

  Nakajima, T ^a   Konda, Y ^a   Izumi, Y ^a   Kanai, M ^a   Takeuchi, T ^b   Chiba, T ^a  

^a KYOTO UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM); CHOLECYSTOKININ B RECEPTOR; GASTRIN; GASTRIN RECEPTOR; GLYCINE; MESSENGER RNA; PROGASTRIN; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING ASSAY; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; GASTRIN BLOOD LEVEL; GENE EXPRESSION; GENE MUTATION; HOMOZYGOSITY; HYPERGASTRINEMIA; IN SITU HYBRIDIZATION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH MUCOSA; STOMACH PARIETAL CELL; TRANSGENE; TRANSGENIC MOUSE; ANIMAL; BLOOD; GENETICS; HYPERTROPHY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CELL DIFFERENTIATION; GASTRIC MUCOSA; GASTRINS; GENE EXPRESSION; H(+)-K(+)-EXCHANGING ATPASE; HYPERTROPHY; IN SITU HYBRIDIZATION; MICE; MICE, INBRED ICR; MICE, TRANSGENIC; PARIETAL CELLS, GASTRIC; RNA, MESSENGER;

EID: 0036545937     PISSN: 09530673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.16.s2.25.x     Document Type: Article

References (23)

1. Gordon JI. Understanding gastrointestinal epithelial cell biology: lessons from mice with help from worms and flies. Gastroenterology 1993; 105: 315-24.
2. Karam SM, Leblond CP. Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell. Anat Rec 1993; 236: 259-79.
3. Karam S, Leblond CP. Origin and migratory pathways of the eleven epithelial cell types present in the body of the mouse stomach. Microsc Res Tech 1995; 31: 193-214.
4. Johnson LR. Regulation of gastrointestinal mucosal growth. Physiol Rev 1988; 68: 456-502.
5. Varro A, Voronina S, Dockray GJ. Pathways of processing of the gastrin precursor in rat antral mucosa. J Clin Invest 1995; 95: 1642-9.
6. Chen MC, Lee AT, Soll AH. Mitogenic response of canine fundic epithelial cells in short-term culture to transforming growth factor alpha and insulinlike growth factor I. J Clin Invest 1991; 87: 1716-23.
7. Murayama Y, Miyagawa J, Higashiyama S, et al. Localization of heparin-binding epidermal growth factor-like growth factor in human gastric mucosa. Gastroenterology 1995; 109: 1051-9.
8. Takahashi M, Ota S, Shimada T, et al. Hepatocyte growth factor is the most potent endogenous stimulant of rabbit gastric epithelial cell proliferation and migration in primary culture. J Clin Invest 1995; 95: 1994-2003.
9. Walsh JH. Role of gastrin as a trophic hormone. Digestion 1990; 47: 11-6, discussion 49-52.
10. Lehy T, Roucayrol AM, Mignon M. Histomorphological characteristics of gastric mucosa in patients with Zollinger-Ellison syndrome or autoimmune gastric atrophy: role of gastrin and atrophying gastritis. Microsc Res Tech 2000; 48: 327-38.
11. Ryberg B, Axelson J, Hakanson R, Sundler F, Mattsson H. Trophic effects of continuous infusion of [Leu 15]-gastrin-17 in the rat. Gastroenterology 1990; 98: 33-8.
12. Matsumoto M, Park J, Sugano K, Yamada T. Biological activity of progastrin posttranslational processing intermediates. Am J Physiol 1987; 252: G315-9.
13. Seva C, Dickinson CJ, Yamada T. Growth-promoting effects of glycine-extended progastrin. Science 1994; 265: 410-2.
14. Wang TC, Koh TJ, Varro A, et al. Processing and proliferative effects of human progastrin in transgenic mice. J Clin Invest 1996; 98: 1918-29.
15. Wang TC, Dangler CA, Chen D, et al. Syncrgislic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology 2000; 118: 36-47.
16. De I, Valle J, Yamada T. Zollinger-Ellison syndrome. In: Yamada Ted. Textbook of Gastroenterology. Philadelphia: Lippincott, 1991; pp. 1340-52.
17. Hayashi N, Kayo T, Sugano K, Takeuchi T. Production of bioactive gastrin from the non-endocrine cell lines CHO and COS-7. FEBS Lett 1994; 337: 27-32.
18. Niwa H, Yamamura K, Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991; 108: 193-9.
19. Konda Y, Yokota H, Kayo T, et al. Proprotein-processing endoprotease furin controls the growth and differentiation of gastric surface mucous cells. J Clin Invest 1997; 99: 1842-51.
20. Fenoglio-Preiser CM, Lantz PE, Listrom MB, Davis M, Rilke FD. Non-neoplastic stomach. In: Gastrointestinal Pathology: A Text Atlas. New York: Raven, 1989; pp. 133-192.
21. Konda Y, Kamimura H, Yokota H, Hayashi N, Sugano K, Takeuchi T. Gastrin stimulates the growth of gastric pit with less-differentiated features. Am J Physiol 1999; 277: G773-84.
22. Iwase K, Evers BM, Hellmich MR, et al. Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin. Gastroenterology 1997; 113: 782-90.
23. Miyazaki Y, Shinomura Y, Tsutsui S, et al. Gastrin induces heparin-binding epidermal growth factor-like growth factor in rat gastric epithelial cells transfected with gastrin receptor. Gastroenterology 1999; 116: 78-89.