Stage-specific effects of the fungicide carbendazim on Sertoli cell microtubules in rat testis

Tissue and Cell

Volumn 34, Issue 2, 2002, Pages 73-80

  Nakai, M ^a   Miller, M G ^b   Carnes, K ^a   Hess, R A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Carbendazim; Immunohistochemistry; Microtubule; Rat; Sertoli cell; Vimentin

Indexed keywords

CARBENDAZIM; FUNGICIDE; TUBULIN; BENZIMIDAZOLE DERIVATIVE; CARBAMIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SHAPE; CELL STRUCTURE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DRUG EFFECT; DRUG EXPOSURE; DRUG SENSITIVITY; ELECTRON MICROSCOPY; GERM CELL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROTUBULE ASSEMBLY; MORPHOLOGY; NONHUMAN; RAT; SEMINIFEROUS TUBULE EPITHELIUM; SERTOLI CELL; SPERMATID; STRUCTURE ANALYSIS; TESTIS; ANIMAL; MICROTUBULE; ORAL DRUG ADMINISTRATION; PATHOLOGY; SPRAGUE DAWLEY RAT; TIME; ULTRASTRUCTURE;

ADMINISTRATION, ORAL; ANIMALS; BENZIMIDAZOLES; CARBAMATES; FUNGICIDES, INDUSTRIAL; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON; MICROTUBULES; RATS; RATS, SPRAGUE-DAWLEY; SERTOLI CELLS; TESTIS; TIME FACTORS; TUBULIN;

EID: 0036545041     PISSN: 00408166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-8166(02)00006-X     Document Type: Article

References (29)

1. Molecular and cellular aspects of the interaction of benzimidazole fungicides with tubulin and microtubules
2. The fungicide methyl 2-benzimidazole carbamate causes infertility in male Sprague-Dawley rats
3. Microtubule depolymerization in rat seminiferous epithelium is associated with diminished tyrosination of α-tubulin
4. Differential binding of methyl benzimidazol-2-yl carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans
5. Increased frequencies of diploid sperm detected by multicolour FISH after treatment of rats with carbendazim without micronucleus induction in peripheral blood erythrocytes
6. Testicular damage after exposure to carbendazim depends on the number of patent efferent ductules
7. Differential post-translational modification of microtubules in cells of the seminiferous epithelium of the rat: A light and electron microscope immunocytochemical study
8. Histological methods for the evaluation of the testis
9. Histopathology of the male reproductive system induced by the fungicide benomyl
10. The fungicide benomyl (methyl 1-(butylcarbamoyl)-2-benzimi dazolecarbamate) causes testicular dysfunction by inducing the sloughing of germ cells and occlusion of efferent ductules
11. The role of the benomyl metabolite carbendazim in benomyl-induced testicular toxicity
12. Role of microtubule-associated proteins in the control of microtubule assembly
13. The fungicide carbendazim induces meiotic micronuclei in the spermatids of the rat testis
14. Morphological changes in the rat Sertoli cell induced by the microtubule poison carbendazim
15. Effects of carbendazim (methyl 2-benzimidazole carbamate MBC) on meiotic spematocytes and subsequent spermiogenesis in the rat testis
16. Acute and long-term effects of a single dose of the fungicide carbendazim (methyl 2-benzimidazole carbamate) on the male reproductive system in the rat
17. Deformation of the rat Sertoli cell by oral administration of carbendazim (methyl 2-benzimidazole carbamate)
18. Early effects of antispermatogenic benzimidazole derivatives U 32.422 E and 32.104 on the seminiferous epithelium of the rat
19. Observations on rat Sertoli ectoplasmic ('junctional') specializations in their association with germ cells of the rat testis
20. Effect of the microtubule disrupting agents, colchicine and vinblastine, on seminiferous tubule structure in the rat
21. Changes in the distribution of microtubules in rat Sertoli cells during spermatogenesis
22. Colchicine-induced changes in the cytoskeleton of the golden mantled ground squirrel (Spermophilus lateralis) Sertoli cells
23. Ectoplasmic ('junctional') specializations in mammalian Sertoli cells: Influence on spermatogenic cells
24. Sertoli cell cytoskeleton
25. Characterization of stage-specific tyrosinated alpha-tubulin immunoperoxidase staining patterns in Sertoli cells of rat seminiferous tubules by light microscopic image analysis
26. A study of intercellular bridges during spermatogenesis in the rat
27. The role of GTP binding and microtubule-associated proteins in the inhibition of microtubule assembly by cardendazim
28. Environmental health criteria 149