Kinetic peculiarities of human tissue kallikrein: 1 - Substrate activation in the catalyzed hydrolysis of H-D-valyl-L-leucyl-L-arginine 4-nitroanilide and H-D-valyl-L-leucyl-L-lysine 4-nitroanilide; 2 - Substrate inhibition in the catalyzed hydrolysis of Nα-p-tosyl-L-arginine methyl ester

Archives of Biochemistry and Biophysics

Volumn 400, Issue 1, 2002, Pages 7-14

  Sousa, M O ^a   Miranda, T L S ^b   Maia, C N ^a   Bittar, E R ^b   Santoro, M M ^b   Figueiredo, A F S ^a  

^a Núcleo de Estudos e Seleção de Biomoléculas da Amazónia Laboratório de Química Farmacéutica Faculdade de Farmácia ICS   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Human tissue kallikrein; Human tissue kallikrein kinetics; Human tissue kallikrein substrate activation; Human tissue kallikrein substrate inhibition; Substrate activation; Substrate inhibition

Indexed keywords

ANILIDE; DEXTRO VALYLLEUCYLARGININE 4 NITROANILIDE; DEXTRO VALYLLEUCYLLYSINE 4 NITROANILIDE; TISSUE KALLIKREIN; TOSYLARGININE METHYL ESTER; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROLYSIS; MICHAELIS CONSTANT; PRIORITY JOURNAL;

EID: 0036544578     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.2002.2764     Document Type: Article

References (36)