Specific sequences in p120ctn determine subcellular distribution of its multiple isoforms involved in cellular adhesion of normal and malignant epithelial cells

Journal of Cell Science

Volumn 115, Issue 7, 2002, Pages 1391-1402

  Aho, Sirpa ^a   Levänsuo, Laura ^a   Montonen, Outi ^a   Kari, Csaba ^a   Rodeck, Ulrich ^a   Uitto, Jouni ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Alternative splicing; Cadherin; Catenin; Cell morphology; Cell cell adhesion; Protein domains

Indexed keywords

CALCIUM; CATENIN; ISOPROTEIN; PROTEIN P120; PROTEIN TYROSINE KINASE; RNA; TYROSINE; UVOMORULIN;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL IMMORTALIZATION; CELL JUNCTION; CELL NUCLEUS; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EPIDERMIS CELL; EXON; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MELANOCYTE; MELANOMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; CADHERINS; CELL ADHESION; CELL ADHESION MOLECULES; CELL COMMUNICATION; CELL MOVEMENT; CELLS, CULTURED; CYTOPLASM; EPITHELIUM; HUMANS; INFANT, NEWBORN; KERATINOCYTES; MELANOCYTES; MICE; MODELS, GENETIC; MUTATION; NEOPLASMS; NUCLEAR LOCALIZATION SIGNALS; PHOSPHOPROTEINS; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

ANIMALIA; ARMADILLO; STAPHYLOCOCCUS PHAGE 3A;

EID: 0036538343     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Human p120(ctn) catenin: Tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen
2. Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors
3. The p120 catenin family: Complex roles in adhesion, signaling and cancer
4. Inhibition of RhoA by p120 catenin
5. p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells
6. Functional interaction of β-catenin with the transcription factor LEF-1
7. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
8. Epithelial cell shape: Cadherins and small GTPases
9. Tyrosine phosphorylation and Scr family kinases control keratinocyte cell-cell adhesion
10. The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or α-catenin
11. The Catenin p120ctn interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor
12. p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: A link between cell-cell contact formation and regulation of cell locomotion
13. Lessons from melanoma development for understanding the biological events in naevus and melanoma formation
14. Growth and invasion of human melanomas in human skin grafted to immunodeficient mice
15. The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin
16. Molecular cloning of the human p120ctn catenin gene (CTNND1): Expression of multiple alternatively spliced isoforms
17. The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors
18. Identification of Src phosphorylation sites in the catenin p120ctn
19. SV-40-transfected human melanocyte sensitivity to growth inhibition by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate
20. cas isoforms in human tumor cell lines
21. Tissue distribution and cell type-specific expression of p120ctn isoforms
22. Rho, rac and cdc42 GTPases: Regulators of actin structures, cell adhesion and motility
23. The role of the E-cadherin/Catenin adhesion complex in the development and progression of cancer
24. p120 catenin regulates the actin cytoskeleton via Rho family GTPases
25. p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity
26. The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts
27. Tyrosine phosphorylation of p120ctn in v-Src transfected L cells depends on its association with E-cadherin and reduces adhesion activity
28. Controversies at the cytoplasmic face of the cadherin-based adhesion complex
29. Dephosphorylation of the cadherin-associated p100/p120 proteins in response to activation of protein kinase C in epithelial cells
30. Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene
31. Identification of a new catenin: The tyrosine kinase substrate p120cas associates with E-cadherin complexes
32. cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts
33. Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors
34. Insights from model systems. The tumor-suppressor function of E-cadherin
35. Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes
36. p120, a p120-related protein (p100), and the cadherin/catenin complex
37. Selective uncoupling of p120ctn from E-cadherin disrupts strong adhesion
38. Nuclear localization of the p120ctn Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression
39. Production and characterization of monoclonal antibodies to the catenin p120ctn
40. ctn
41. Receptor protein-tyrosine phosphatase RPTPμ binds to and dephosphorylates the catenin p120ctn