Assay of TNP-470 and its two major metabolites in human plasma by high-performance liquid chromatography-mass spectrometry

Journal of Chromatographic Science

Volumn 40, Issue 4, 2002, Pages 214-218

  Whalen, C T ^a   Hanson, G D ^a   Putzer, K J ^a   Mayer, M D ^b   Mulford, D J ^b  

^a 206 Carnegie Center   (United States)

^b TAP PHARMACEUTICAL PRODUCTS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGM 1883; DRUG METABOLITE; FUMAGILLOL CHLOROACETYLCARBAMATE; HEXANE; ORGANIC SOLVENT; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG;

ACCURACY; ACIDIFICATION; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; STANDARD;

EID: 0036526561     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/40.4.214     Document Type: Article

References (6)

1. Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes
2. The pharmacokinetics of TNP-470, a new angiogenesis inhibitor
3. Assay of the antiangiogenic compound TNP-470, and one of its metabolites, AGM-1883, by reversed-phase high-performance liquid chromatography in plasma
4. Determination of O-(chloroacetyl-carbamoyl)fumagillol (TNP-470; AGM-1470) and two metabolites in plasma by high-performance liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization
5. Quantitation of TNP-470 and its metabolites in human plasma: Sample handling, assay performance and stability