Synthesis and pharmacological activity of 3-hydroxy-1, 5-diaryl-4-pivaloyl-2, 5-dihydro-2-pyrrolones

Pharmaceutical Chemistry Journal

Volumn 36, Issue 4, 2002, Pages 188-191

  Koz'minykh, V O ^a   Igidov, N M ^a   Zykova, S S ^a   Kolla, V E ^a   Shuklina, N S ^a   Odegova, T F ^a  

^a PERM STATE PHARMACEUTICAL ACADEMY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 5 (4 NITROPHENYL) 4 PIVALOYL 1 (4 TOLYL) 2,5 DIHYDRO 2 PYRROLONE; 4 ACETYL 3 HYDROXY 5 (4 METHOXYPHENYL) 1 (4 TOLYL) 2,5 DIHYDRO 2 PYRROLONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; ETHACRIDINE; FLUMEQUINE; HALICHONDRIN DERIVATIVE; NALIDIXIC ACID; OXOLINIC ACID; PACLITAXEL; PIRACETAM; PIVALOYL DIHYDROPYRROLONE DERIVATIVE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIOSTASIS; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL STRAIN MCF 7; CENTRAL NERVOUS SYSTEM TUMOR; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; EXPERIMENTAL TEST; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHYSICAL CHEMISTRY; RAT; REACTION ANALYSIS; SPECTROSCOPY; STAPHYLOCOCCUS AUREUS; STATISTICAL SIGNIFICANCE; STRUCTURE ANALYSIS;

EID: 0036526152     PISSN: 0091150X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1019832621371     Document Type: Article

References (16)

1. V. L. Gein and Yu. S. Andreichikov, The Chemistry of Five-Member 2, 3-Dioxoheterocycles [in Russian], Perm State University, Perm (1994), pp. 166-188.
2. Yu. S. Andreichikov, V. L. Gein and I. N. Anikina, Zh. Org. Khim. 22(8), 1749-1756 (1986).
3. V. L. Gein, E. V. Shumilovskikh, Yu. S. Andreichikov, et al., Khim.-Farm. Zh., 25(12), 37-40 (1991).
4. V. L. Gein, L. F. Gein, N. Yu. Porseva, et al., Khim.-Farm. Zh., 31(5), 33-36 (1997).
5. V. L. Gein, S. G. Pitirimova, É. V. Voronina, et al., Khim.-Farm. Zh., 31(11), 35-36 (1997).
6. V. L. Gein, L. F. Gein, N. Yu. Porseva, et al., Khim.-Farm. Zh., 32(9), 23-25 (1998).
7. V. L. Gein, N. N. Kasimova, É. V. Voronina, and L. F. Gein, Khim.-Farm. Zh., 35(3), 31-34 (2001).
8. É. N. Bezmaternykh, Author's Abstract of Cand. Sci. (Chem.) Thesis [in Russian], Perm (2000).
9. V. O. Koz'minykh, N. M. Igidov, E. S. Berezina, et al. Izv. Ross. Akad. Nauk, Ser. Khim., No. 9, 1564-1568 (2000).
10. S. S. Shirinkina, N. M. Igidov, and V. O. Koz'minykh, Abstracts of Papers. The Jubilee Interinstitution Sci.-Pract. Conf. "80 Years of Pharmaceutical Educational in Urals: Achievements and Prospects" (1998), pp. 62-63.
11. S. S. Shirinkina, N. M. Igidov, E. S. Berezina, and V. O. Koz'minykh, in: Current Problems in Pharmacological Science and Education: Achievements and Prospects" [in Russian], Perm State Pharmaceutical Academy, Perm (2000), p. 82.
12. E. E. Royals, J. Am. Chem. Soc., 67, 1508-1509 (1945).
13. G. N. Pershin, Methods of Experimental Chemotherapy [in Russian], Medgiz, Moscow (1971), pp 100, 109-117.
14. M. R. Grever, S. A. Schepartz, and B. A. Chabner, Seminars in Oncology, 19(6), 622-638 (1992).
15. P. Skehan, R. Storfeng, D. Scudiero, et al., J. Natl. Cancer Inst., 82, 1107-1112 (1990).
16. L. V. Loskutova and R. Yu. Il'yuchenok, Farmakol. Toksikol., 48(4), 34-38 (1985).