Facile synthesis of 9-substituted 9-deazapurines as potential purine nucleoside phosphorylase inhibitors

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 3, 2002, Pages 364-367

  Shih, Hsiencheng ^a   Cottam, Howard Brinkerhoff ^a   Carson, Dennis Anthony ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

9 aroyl 9 deazapurine; 9 arylmethyl 9 deazpurine; 9 deazahypoxanthine; 9 deazapurine; Purine nucleoside phosphorylase inhibitor

Indexed keywords

FORMIC ACID DERIVATIVE; HYPOXANTHINE DERIVATIVE; NICKEL; PURINE DERIVATIVE; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; PYRIMIDINE DERIVATIVE; TRIFLUOROACETIC ACID; TRIFLUOROMETHANESULFONIC ACID; ENZYME INHIBITOR;

ARTICLE; CATALYST; DRUG SYNTHESIS; FRIEDEL CRAFTS REACTION; REDUCTION; WOLFF KISHNER REDUCTION; DRUG ANTAGONISM; METHYLATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; PURINES;

EID: 0036519159     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.364     Document Type: Article

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