Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer

Oncology Reports

Volumn 9, Issue 2, 2002, Pages 289-292

  Mizutani, Yoichi ^a   Wada, Hiromi ^b   Yoshida, Osamu ^b   Fukushima, Masakazu ^c   Bonavida, Benjamin ^d   Kawauchi, Akihiro ^a   Miki, Tsuneharu ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bladder cancer; Dihydropyrimidine dehydrogenase; Prognosis; Recurrence; Thymidylate synthase

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; OXIDOREDUCTASE; THYMIDYLATE SYNTHASE; TUMOR MARKER;

ADULT; AGED; ARTICLE; BLADDER TUMOR; CANCER STAGING; DISEASE COURSE; DISEASE FREE SURVIVAL; ENZYMOLOGY; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; POSTOPERATIVE CARE; PROGNOSIS; TRANSITIONAL CELL CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, TRANSITIONAL CELL; DIHYDROURACIL DEHYDROGENASE (NADP); DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; OXIDOREDUCTASES; POSTOPERATIVE CARE; PROGNOSIS; THYMIDYLATE SYNTHASE; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 0036515641     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.9.2.289     Document Type: Article

References (11)

1. Navalgund LG, Rossano C and Muench AJ: Cell cycle regulation of thymidylate synthase gene expression in cultured mouse fibroblasts. J Biol Chem 255: 7386-7390, 1980.
2. Danenberg PV: Thymidylate synthase: a target enzyme in cancer chemotherapy. Biochem Biophys Acta 473: 73-92, 1977.
3. Lu Z, Zhang R and Diasio RB: Purification and characterization of dihydropyrimidine dehydrogenase from human liver. J Biol Chem 267: 17102-17109, 1992.
4. Yokota H, Fernandez-Salguero P, Furuya H, Lin K, McBride OW, Podschun B, Schnackerz KD and Gonzalez FJ: cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria. J Biol Chem 269: 23192-23196, 1994. (Pubitemid 24283306)
5. Mizutani Y, Wada H, Ogawa O, Yoshida O, Fukushima M, Nonomura N and Miki T: Prognostic significance of thymidylate synthase activity in bladder cancer. Cancer 92: 510-518, 2001. (Pubitemid 32735185)
6. Mizutani Y, Wada H, Fukushima M, Yoshida O, Ukimura O, Kawauchi A and Miki T: Significance of dihydropyrimidine dehydrogenase activity in bladder cancer. Eur J Cancer 37: 569-575, 2001. (Pubitemid 32261013)
7. Lamm DL, van der Meijden APM, Akaza H, Brendler CHB, Hedlund PO, Mizutani Y, Ratliff TL, Robinson MRG and Shinka T: Intravesical chemotherapy and immunotherapy: how do we assess their effectiveness and what are their limitations and uses? Int J Urol 2: 23-35, 1995.
8. Mizutani Y, Nakanishi H, Yoshida O, Fukushima M, Bonavida B and Miki T: Potentiation of the sensitivity of renal cell carcinoma cells to TRAIL-mediated apoptosis by subtoxic concentrations of 5-fluorouracil. Eur J Cancer (In press).
9. Chu E, Voeller DM and Jones KL: Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells. Mol Cell Biol 14: 207-213, 1994.
10. Weber G: Enzymology of cancer cells. N Engl J Med 296: 486-493, 1977.
11. Queener SF, Morris HP and Weber G: Dihydrouracil dehydrogenase activity in normal, differentiating, and regenerating liver and in hepatomas. Cancer Res 31: 1004-1009, 1971.