Synthesis and calcium channel antagonist activity of nifedipine analogues with methylthioimidazole substituent

Farmaco

Volumn 57, Issue 3, 2002, Pages 195-199

  Foroumadi, A ^a,b   Analuie, N ^a   Rezvanipour, M ^a   Sepehri, G ^a   Najafipour, H ^a   Sepehri, H ^a   Javanmardi, K ^a   Esmaeeli, F ^a  

^a KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Calcium channel blockers; Dihydropyridines

Indexed keywords

3 BUTYL 5 ETHYL 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINECARBOXYLATE; 3 BUTYL 5 METHYL 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINECARBOXYLATE; 3 ETHYL 5 (1 METHYLETHYL) 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINEDICARBOXYLATE; 3 ETHYL 5 METHYL 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINEDICARBOXYLATE; 3 ETHYL 5 PROPYL 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINEDICARBOXYLATE; 3 METHYL 5 (1 METHYLETHYL) 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINEDICARBOXYLATE; 3 METHYL 5 PROPYL 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINEDICARBOXYLATE; BIS(1 METHYLETHYL) 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINEDICARBOXYLATE; CALCIUM CHANNEL BLOCKING AGENT; DIBUTYL 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINEDICARBOXYLATE; DIETHYL 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINEDICARBOXYLATE; DIHYDROPYRIDINE; DIMETHYL 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINEDICARBOXYLATE; DIPROPYL 1,4 DIHYDRO 2,6 DIMETHYL 4 (1 METHYL 2 METHYLTHIO 5 IMIDAZOLYL) 3,5 PYRIDINEDICARBOXYLATE; ESTER DERIVATIVE; IMIDAZOLE DERIVATIVE; NIFEDIPINE DERIVATIVE; PHENYL GROUP; PROPANE; UNCLASSIFIED DRUG; DIHYDROPYRIDINE DERIVATIVE; DRUG DERIVATIVE; NIFEDIPINE; POTASSIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; GUINEA PIG; IC 50; ILEUM; MALE; NONHUMAN; SMOOTH MUSCLE; STANDARDIZATION; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; METABOLISM; MUSCLE CONTRACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CALCIUM CHANNEL BLOCKERS; DIHYDROPYRIDINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; ILEUM; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NIFEDIPINE; POTASSIUM CHLORIDE; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036513963     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01191-0     Document Type: Article

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