Syntheses of 1β-methylcarbapenems bearing 5-methyl-4- hydroxypyrrolidinone

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 3, 2002, Pages 415-418

  Pyun, Do Kyu ^a,b   Kim, Bong Jin ^a   Jung, Hee Jung ^a   Kim, Jae Hak ^a   Lee, Jin Soo ^c   Lee, Won Koo ^b   Lee, Cheol Hae ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Sogang University   (South Korea)

^c DongWha Pharm Ind Co   (South Korea)

Author keywords

hydroxy amino acid; ketoester; Carbapenem; Hydrogenation; Mitsunobu reaction

Indexed keywords

1BETA METHYLCARBAPENEM DERIVATIVE; 6 (1 HYDROXYETHYL) 4 METHYL 7 OXO 3 (5 OXO 3 PYRROLIDINYLTHIO) 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; AZIRIDINE DERIVATIVE; MEROPENEM; PEPTIDASE; PYRROLIDINE DERIVATIVE; SODIUM 6 (1 HYDROXYETHYL) 1 METHYL 2 (2 METHYL 5 OXOPYRROLIDIN 3 YLTHIO) 1 CARBAPEN 2 EM 3 CARBOXYLATE; UNCLASSIFIED DRUG; 2 PYRROLIDONE DERIVATIVE; 5 METHYL 4 HYDROXYPYRROLIDINONE; 5-METHYL-4-HYDROXYPYRROLIDINONE; ANTIINFECTIVE AGENT; CARBAPENEM DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; ENANTIOMER; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; MICROBIOLOGICAL EXAMINATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ANTI-INFECTIVE AGENTS; CARBAPENEMS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; PYRROLIDINONES;

EID: 0036512741     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.415     Document Type: Article

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