Significance of AgNORs in tumour pathology;Significato delle AgNOR in patologia tumorale

Pathologica

Volumn 94, Issue 1, 2002, Pages 2-9

  Pich, A ^a   Margaria, E ^b   Chiusa, L ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

Author keywords

AgNOR; Diagnostic role; Prognostic role; Tumour pathology

Indexed keywords

SILVER;

CHROMOSOME NOR; DIAGNOSTIC TEST; REVIEW; TUMOR; ADULT; CANCER INVASION; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CHILD; EDITORIAL; FEMALE; FLOW CYTOMETRY; FORECASTING; HUMAN; MALE; MORTALITY; NEOPLASM; PROGNOSIS; SILVER STAINING; ULTRASTRUCTURE;

ADULT; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CHILD; FEMALE; FLOW CYTOMETRY; FORECASTING; HUMANS; MALE; NEOPLASM INVASIVENESS; NEOPLASMS; NUCLEOLUS ORGANIZER REGION; PROGNOSIS; SILVER STAINING;

EID: 0036484721     PISSN: 00312983     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (53)

1. Heitz E (1931) Die Ursache der gesetzmässigen Zahl, Lage, Form und Grösse pflanzlicher Nukleolen. Planta 12:775-844
2. Howell WM (1982) Selective staining of nucleolus organizer regions (NORs). In: Busch H, Rothblum L (eds) The cell nucleus. Academic Press, New York, pp 89-143
3. Lischwe MA, Smetana K, Olson MOJ, Busch H (1979) Protein C23 and B23 are the major nucleolar silver staining proteins. Life Sci 25:701-708
4. Derenzini M, Sirri V, Trerè D (1994) Nucleolar organizer regions in tumor cells. Cancer J 7:71-77
5. Buys C, Osinga J (1980) Abundance of protein-bound sulphydryl and disulfide groups at chromosomal nucleolus organizing regions. Chromosoma (Berl.) 77:1-11
6. Page RC, Regan JF, MacCarty WC (1938) Intranucleolar bodies in normal and neoplastic human tissue. Am J Cancer 32:383-394
7. Love R, Takeda M, Soriano RZ et al (1973) The value of the internal structure of the nucleolus in the diagnosis of malignancy. Acta Cytol 17:310-315
8. Howell M, Black DA (1980) Controlled silver-staining of nucleolar organizer regions with a protective colloidal developer: a 1 step method. Experientia 36:1014-1015
9. A. Pich et al.: Significato delle AgNOR in patologia tumorale 9. Ploton D, Menager M, Jeannesson P et al (1986) Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organizer region at the optical level. Histochem J 18:5-14
10. Crocker J, Skilbeck N (1987) Nucleolar organizer regions in melanocytic lesions: a quantitative study. J Clin Pathol 40:885-889
11. Crocker J, Nar P (1987) Nucleolar organizer regions in lymphomas. J Pathol 151:111-118
12. - (1987) NORs: a new method for the pathologist. Lancet 1:1413-1414
13. Giri DD, Nottingham JF, Lawry J et al (1989) Silver-binding nucleolar organizer regions (AgNORs) in benign and malignant breast lesions: correlation with ploidy and growth phase by DNA flow cytometry. J Pathol 157:307-313
14. Dervan PA, Gilmartin LG, Loftus BM, Carney DN (1989) Breast carcinoma kinetics. Argyrophilic nucleolar organizer region counts correlate with Ki67 scores. Am J Clin Pathol 92:401-407
15. Raymond WA, Leong AS (1989) Nucleolar organizer regions related to growth fraction in human breast carcinoma. Hum Pathol 20:741-746
16. Derenzini M, Betts CM, Trerè D et al (1990) Diagnostic value of silver-stained interphase nucleolar organizer regions in breast cancer. Ultrastruct Pathol 14:233-245
17. Nairn ER, Crocker J, McGovern J (1988) Limited value of AgNOR enumeration in assessment of thyroid neoplasm. J Clin Pathol 41:1136
18. Derenzini M, Nardi F, Farabegoli F et al (1989) Distribution . of silver-stained interphase nucleolar organizer regions as a parameter to distinguish neoplastic from nonneoplastic reactive cells in human effusions. Acta Cytol 33:491-498
19. Pich A, Chiusa L, Margaria E, Aloi F (1993) Proliferative activity in the malignant cellular blue nevus. Hum Pathol 24:1323-1329
20. Egan MJ, Raafat F, Crocker J, Williams D (1988) Comparative study of the degree of differentiation of neuroblastoma and mean numbers of nucleolar organiser regions. J Clin Pathol 41:527-531
21. Bostock DE, Crocker J, Harris K, Smith P (1989) Nucleolar organiser regions as indicators of post-surgical prognosis in canine spontaneous mast cell tumours. Br J Cancer 59:915-918
22. Moran K, Cooke T, Foster G et al (1989) Prognostic value of nucleolar organizer regions and ploidy values in advanced colorectal cancer. Br J Surg 76:1152-1155
23. Öfner D, Tötsch M, Sandbichler P et al (1990) Silver stained nucleolar organizer region proteins (AgNORs) as a predictor of prognosis in colonic cancer. J Pathol 162:43-49
24. Rüschoff J, Bittinger A, Neumann K et al (1990) Prognostic significance of Nucleolar Organizing Regions (NORs) in carcinomas of the sigmoid colon and rectum. Path Res Pract 186:85-91
25. Kajiwara K, Nishizaki T, Orita T et al (1990) Silver colloid staining technique for analysis of glioma malignancy. J Neurosurg 73:113-117
26. Trerè D (1998) Quantitative analysis of AgNOR proteins: a reliable marker of the rapidity of cell duplication and a significant prognostic parameter in tumour pathology. Adv Clin Pathol 2:261-270
27. Pich A, Chiusa L, Margaria E (2000) Prognostic relevance of AgNORs in tumor pathology. Micron 31:133-141
28. Pich A, Pisani P, Krengli M et al (1991) Argyrophilic nucleolar organizer region counts and prognosis in pharyngeal carcinoma. Br J Cancer 64:327-332
29. Pich A, Marmont F, Chiusa L et al (1992) Argyrophilic nucleolar organizer region counts and prognosis in multiple myeloma. Br J Haematol 82:681-688
30. Pich A, Chiarle R, Chiusa L, Palestre G (1994) Argyrophilic nucleolar organizer region counts predict survival in thymoma. Cancer 74:1568-1574
31. Pich A, Margaria E, Chiusa L (1994) In male breast carcinoma the proliferative activity is a significant prognostic factor. Am J Pathol 145:481-489
32. Pich A, Chiarle R, Chiusa L et al (1995) Long-term survival of thymoma patients by histologic pattern and proliferative activity. Am J Surg Pathol 19:918-926
33. Pich A, Margaria E, Chiusa L et al (1996) DNA ploidy and p53 expression correlate with survival and cell proliferative activity in male breast carcinoma. Hum Pathol 27:676-682
34. Pich A, Chiusa L, Marmont F, Navone R (1997) Risk groups of myeloma patients by histologic pattern and proliferative activity. Am J Surg Pathol 21:339-347
35. Pich A, Margaria E, Chiusa L, Formiconi A (1997) Prognostic value of AgNOR counting. A prospective study in a series of renal cell carcinomas. Oncol Rep 4: 749-751
36. Chiusa L, Galliano D, Formiconi A et al (1997) High and low risk prostate carcinoma determined by histologic grade and proliferative activity. Cancer 79:1956-1963
37. Pich A, Chiusa L, Audisio E, Marmont F ( 1998) Nucleolar organizer region counts predict complete remission, remission duration and survival in adult myelogeneous leukemia patients. J Clin Oncol 16:1512-1518
38. Derenzini M, Ploton D (1991) Interphase nucleolar organizer regions in cancer cells. In: Richter GW, Solez K (eds) International Review of Experimental Pathology: Molecular cell pathology. Academic Press, San Diego, pp 149-192
39. Derenzini M, Trerè D (1991) Importance of interphase nucleolar organizer regions in tumor pathology. Virchows Archiv B Cell Pathol 61:1-8
40. Egan MJ, Crocker J (1992) Nucleolar organizer regions in pathology. Br J Cancer 65:1-7
41. Derenzini M, Trerè D (2001) Stato dell'arte sulle AgNOR. Pathologica 93:99-105
42. Pich A, Chiusa L, Margaria E (1995) Role of the argyrophilic nucleolar organizer regions in tumor detection and prognosis. Cancer Detect Prev 19:282-293
43. Pich A, Chiusa L, Comino A, Navone R (1994) Cell proliferation indices, morphometry and DNA flow cytometry provide objective criteria for distinguishing low and high grade bladder carcinomas. Virchows Archiv A Pathol Anat 424:143-148
44. Pich A, Valente G, Margaria E et al (1991) Argyrophilic nucleolar organizer region counts and Ki67 scores in human renal cell carcinoma. Path Res Pract 187:482-486
45. Pich A, Chiusa L, Pisani P et al (1992) Argyrophilic nucleolar organizer region counts and proliferating cell nuclear antigen scores are two reliable indicators of survival in pharyngeal carcinoma. J Cancer Res Clin Oncol 119:106-110
46. Marmont F, Pich A, Chiusa L et al (1996) Correlation between argyrophilic nucleolar organizer region counts and labelling index in multiple myeloma. Eur J Haematol 56:39-44
47. Derenzini M, Sirri V, Trerè D, Ochs RL (1995) The quantity of nucleolar proteins nucleolin and protein B23 is related to cell doubling time in human cancer cells. Lab Invest 73:497-502
48. Piffko J, Bankfalvi A, Öfner D et al (1997) Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumour front of oral squamous cell carcinomas. Br J Cancer 75:1543-1546
49. Öfner D, Aubele M, Biesterfeld S et al (1995) Guidelines of AgNOR quantification. First update. Virchows Arch 427:341
50. Öfner D, Riedman B, Maier H et al (1995) Standardized staining and analysis of argyrophilic nucleolar organizer region associated proteins (AgNORs) in radically resected colorectal adenocarcinoma. Correlation with tumour stage and long-term survival. J Pathol 175:441-448
51. Giuffrè G, Caruso RA, Barresi G, Tuccari G (1998) Prognostic significance of standardized AgNOR analysis in early and advanced gastric carcinomas. Virchows Archiv 433:261-266
52. Bigras G, Marcelpoil R, Brambilla E, Brugal G (1996) Interest of targeting AgNOR measurement in cycling cells: in vivo cell kinetic evaluation of non-small cell lung cancer. Anal Cell Pathol 11:183-198
53. Jacquet B, Canet V, Giroud F et al (2001) Quantitation of AgNORs by flow versus image cytometry. J Histochem Cytochem 49:433-437