Design and synthesis of sulfur based inhibitors of matrix metalloproteinase-1

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 2, 2002, Pages 239-252

  Fujisawa, Tetsunori ^a   Odake, Shinjiro ^a   Ogawa, Yuji ^a   Yasuda, Junko ^a   Morita, Yasuo ^a   Morikawa, Tadanori ^a  

^a FUJI CHEMICAL INDUSTRIES LTD   (Japan)

Author keywords

mercaptocarbonyl; In vitro activity; Inhibitor; Isoserine; Matrix metalloproteinase

Indexed keywords

CARBOXYLIC ACID; ENZYME INHIBITOR; FUNCTIONAL GROUP; HYDROXAMIC ACID; INTERSTITIAL COLLAGENASE INHIBITOR; MATRIX METALLOPROTEINASE 1 INHIBITOR; N ALPHA [3 (TERT BUTYLOXYCARBONYLAMINO) 2 MERCAPTOPROPIONYL]LEUCYL O METHYLTYROSINE N METHYLAMIDE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; ZINC; INTERSTITIAL COLLAGENASE; PROTEINASE INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STEREOCHEMISTRY; SUBSTITUTION REACTION; DRUG ANTAGONISM; SYNTHESIS;

DRUG DESIGN; MATRIX METALLOPROTEINASE 1; PROTEASE INHIBITORS;

EID: 0036482337     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.239     Document Type: Article

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