Interferon-α resistance in renal carcinoma cells is associated with defective induction of signal transducer and activator of transcription I which can be restored by a supernatant of phorbol 12-myristate 13-acetate stimulated peripheral blood mononuclear cells

British Journal of Cancer

Volumn 86, Issue 3, 2002, Pages 449-455

  Brinckmann, A ^a   Axer, S ^a   Jakschies, D ^b   Dallmann, I ^a   Grosser, J ^a   Patzelt, T ^c   Bernier, T ^b   Emmendoerffer, A ^b   Atzpodien, J ^a,c,d  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^c Europ Inst for Tum Immunology/P   (Germany)

^d UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Cancer therapy; Cytokine; Jak; Signal transduction pathway

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; JANUS KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN TYROSINE KINASE; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT GAMMA INTERFERON; RETINOIC ACID; STAT PROTEIN; TAMOXIFEN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; IMMUNOMODULATION; KIDNEY CARCINOMA; MONONUCLEAR CELL; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CARCINOMA, RENAL CELL; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; HUMANS; INTERFERON ALFA-2A; KIDNEY NEOPLASMS; LEUKOCYTES, MONONUCLEAR; STAT1 TRANSCRIPTION FACTOR; TETRADECANOYLPHORBOL ACETATE; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0036473507     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600066     Document Type: Article

References (29)

1. 2-5A synthetase activity does not increase in interferon-resistant Friend leukemia cell variants treated with alpha/beta interferon despite the presence of high-affinity interferon receptor sites
2. JAKs, STATs and signal transduction in response to the interferons and other cytokines
3. Interferon-α in malignant and viral diseases
4. Interferon-resistant Daudi cells are deficient in interferon-alpha-induced ISGF3 alpha activation, but remain sensitive to the interferon-alpha-increase in the ISGF3 gamma content
5. Targeted disruption of the mouse STAT1 gene results in compromised innate immunity to viral disease
6. Establishment and characterization of human renal cancer and normal kidney cell lines
7. Interferon-receptors on the surface of interferon-sensitive and interferon-resistant urothelial carcinomas
8. Participation of Jak and STAT proteins in growth hormone-induced signaling
9. Characterization and regulation of α-interferon receptor expression in interferon-sensitive and -resistant human lymphoblastoid cells
10. Signal transduction in the interferon system
11. STATs: Signal transducers and activators of transcription
12. Modulation of interferon (IFN) - Inducible gene-expression by retinoic acid. Upregulation of STAT1 in IFN-unresponsible cells
13. Regulation of STAT-dependent pathways by growth factors and cytokines
14. Tamoxifen enhances interferon-regulated gene expression in breast cancer cells
15. Targeted disruption of the STAT1 gene in mice reveals unexpected physiologic specifity in the JAK-STAT signaling pathway
16. Complementation of a mutant cell line: Central role of the 91 kDa polypeptide of ISGF3 in the interferon-α and -γ signal transduction pathways
17. Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha
18. Interferons and their actions
19. Antitumor activity of recombinant-derived interferon alpha in metastatic renal cell carcinoma
20. Isolation and characterization of an interferon-resistant cell line deficient in the induction of (2′-5′)oligoadenylate synthetase activity
21. Transcriptional response to polypeptide ligands: The JAK-STAT Pathway
22. Resistance to recombinant interferon-alpha-2a in hairy cell leukemia associated with neutralizing anti-interferon antibodies
23. Interferon-α resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression
24. Interferon-stimulated genes in interferon-sensitive and -resistant chronic myelogenous leukemia patients
25. Repression of IL-4-induced gene expression by IFN-gamma requires Stat1 activation
26. Interferon-resistent human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48-ISGF3gamma;
27. Primary leukemia cells resistant to alpha-interferon in vitro are defective in the activation of the DNA-binding factor interferon-stimulated gene factor 3
28. STAT3 complements defects in an interferon-resistant cell line: Evidence for an essential role for STAT3 in interferon signaling and biological activities