Direct-injection HPLC assay for the determination of a new carbapenem antibiotic in human plasma and urine

Journal of Pharmaceutical and Biomedical Analysis

Volumn 27, Issue 5, 2002, Pages 755-770

  Zhang, Jin ^a   Musson, Donald G ^a   Birk, Kimberly L ^a   Cairns, Ann M ^a   Fisher, Alison L ^a   Neway, William ^a   Rogers, John D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Carbapenem antibiotic; Column switching; Direct injection HPLC; Ion pair; Plasma; Urine

Indexed keywords

ACETONITRILE; ANTIBIOTIC AGENT; BUFFER; CARBAPENEM DERIVATIVE; DRUG METABOLITE; METHANOL; METICILLIN; PHOSPHATE; VANCOMYCIN;

ANALYTIC METHOD; ANALYTICAL EQUIPMENT; ARTICLE; BLOOD SAMPLING; CENTRIFUGATION; CONTROLLED STUDY; DOSIMETRY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG URINE LEVEL; HUMAN; ION PAIR CHROMATOGRAPHY; LIGHT ABSORPTION; METABOLITE; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TECHNIQUE; THAWING; URINALYSIS;

CARBAPENEMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS;

EID: 0036468588     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(01)00500-3     Document Type: Article

References (4)

1. Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic
2. Determination of imipenem (N-formimiodoyl thienamycin) in human plasma and urine by high performance liquid chromatography, comparison with microbiological methodology and stability
3. High performance liquid chromatographic methods for the determination of a new carbapenem antibiotic, L-749,345, in human plasma and urine
4. Column-switching high-pressure liquid chromatographic method for the determination of a new carbapenem antibiotic, L-739,428, in rat and monkey plasma